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6 articles for “Glioblastoma”
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Research ArticleOpen accessEvery word in the titleInflammatory Effects of Co-Exposure to Heavy Metals (Cd and Pb) and Respiratory Viruses (229E, OC43, and H3N2) on IL-6 and IL-8 Responses in U87 Glioblastoma CellsHyeokjun Yun, Qian-Wen Wang, Jae Kyung KimCo-exposure to heavy metals and viruses can pose threats to cellular health by increasing cytotoxicity and inflammatory cytokine expression. We aimed to elucidate the interactions between these factors inhuman glioblastoma cells (U87). U87 cells were exposed to influenza A virus (H3N2), coronaviruses OC43 and 229E, and heavy metals Cd and Pb. Cell viability and cytotoxicity were assessed through WST-8 and … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 5 Jul 2025 · 5,505 accessesView PDFCite
Literature ReviewOpen accessIn the keywordsThe Practical Consideration of Poliovirus as an Oncolytic VirotherapyElizabeth Denniston, Hannah Crewdson, Nicole Rucinsky et al.The inauguration of novel treatment strategies into the clinical setting faces a number of hurdles. In addition to treatment efficacy and safety, acceptance by doctors and patients is paramount to the success of novel therapies. Although viruses are the cause of numerous infectious diseases, these acellular entities have been harnessed over the years to benefit mankind. Recently, a recombinant Poliovirus-Rhinovirus … …Current Research in Virology, Vol. 5, Issue 1 · 3 Mar 2016 · 27,150 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRole of Cytokines in the Regulation of Glioma Tumour Growth and AngiogenesisChristina Piperi, Athanasios Zisakis, Robert W. Lea, Anastasios KalofoutisMalignant glioblastomas are the most common type of primary brain tumors accounting for more than 50% of all intracranial gliomas. Due to their aggressive nature, recurrent growth, and their extremely poor prognosis for survival, research approaches have made little progress in advancing treatment of these tumours which have the ability of both modulating host immune function and neutralizing immune-based therapies. … …American Journal of Immunology, Vol. 1, Issue 3 · 30 Sep 2005 · 6,868 accessesView PDFCite
Research ArticleOpen accessIn the abstractResponses of Neural Cells (U87) to HCoV-229E and HCoV-OC43 InfectionsEun Ju Oh, Jae-Sik Jeon, Qian-Wen Wang, Jae Kyung KimRespiratory viruses, such as Coronaviruses (CoVs), can be neuroinvasive and exacerbate neurological pathologies via their capacity for direct viral replication and/or by inducing excessive host immune responses in the Central Nervous System (CNS). HCoV-229E is a primary COVID-19 and HCoV-OC43 is a beta COVID-19 belonging to the same genus as SARS-CoV-2 and both can cause acute infections in glioblastoma, neuroblastoma, … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 2 · 8 Jun 2023 · 5,181 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of U6 snRNA Transcription by PTENStephanie Cabarcas, Kounosuke Watabe, Laura SchrammProblem statement: RNA polymerase III (RNA pol III) is responsible for transcribing many of the small structural RNA molecules involved in RNA processing and protein translation, thereby regulating the growth rate of a cell. RNA pol III transcribes both gene internal (tRNA) and gene external (U6 snRNA) promoters and proper initiation by RNA polymerase III requires the transcription initiation factor … …OnLine Journal of Biological Sciences, Vol. 10, Issue 3 · 30 Sep 2010 · 8,551 accessesView PDFCite