Research ArticleOpen accessPhrase in the titleImproved SDA Production in High Lipid Accumulating Strain of Mucor circinelloides WJ11 by Genetic ModificationJunhuan Yang, Md. Ahsanul Kabir Khan, Sergio López-García et al.Stearidonic Acid (SDA; 18:4, n-3) is a ω-3 polyunsaturated fatty acid which is nutritionally important and has pharmaceutical applications. Hence, scientists are trying to construct SDA producing oleaginous microorganisms by genetic modification. Two enzymes, Delta-6 Desaturase (D6D) and ω-3 desaturase catalyze the reactions to produce SDA from Linoleic Acid (LA; 18:2, n-6). But the key enzyme, ω-3 desaturase converts LA … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 23 Mar 2020 · 8,240 accessesView PDFCite
Literature ReviewOpen accessIn the keywordsIntracranial Atherosclerotic Disease: Treatment Potential and Diagnostic OpportunitiesAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Anton Yuvenalievich Postnov et al.Atherosclerosis, characterized by the accumulation of atherosclerotic plaques within large arteries, substantially increases the risk of cardiovascular events, including ischemic stroke. Intracranial atherosclerotic disease (ICAD) represents a particularly significant clinical threat given its strong association with ischemic stroke across multiple intracranial arterial territories. This review provides a comprehensive analysis of the pathogenesis, diagnosis, and management of intracranial atherosclerosis. Special attention … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 5 May 2026 · 1,093 accessesView PDFCite
Research ArticleOpen accessIn the keywordsConstruction of Recombinant Bioleaching Bacteria Thiobacillus ferrooxidans with Fluoride-Resistant ActivityYun-Chang Cao, Hong-Bo Wen, Nan Hu et al.Thiobacillus ferrooxidans is an important bioleaching bacterium, widely used in leaching, recovery of low-grade metals and environmental bioremediation. In bio-metallurgy industry, fluoride existing in some hard rock uranium deposits in south China severely affects the bacteria viability and inhibit leaching reproduction. In this study, the flr-4 gene that has strong resistance to fluorine ion in Caenorhabditis elegans, was cloned into … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 2 · 23 May 2018 · 11,341 accessesView PDFCite
Research ArticleOpen accessIn the abstractExplainability Aware Heterogeneous Temporal Graph Transformer for Automated Genetic Disorder Detection from Genomic DataPuvaneswari Subramaniapillai, Indirani Govindasamy, Revathy GurumurthyGenetic disorders affect millions worldwide, posing major challenges for accurate diagnosis and effective treatments. New developments in genomic technologies, especially Next-Generation Sequencing (NGS), have enhanced the classification of genetic modification and improved diagnostic abilities. Moreover, the Machine Learning (ML) and Deep Learning (DL) methods emerged as efficient tools for evaluating the intricate genomic data and determining the patterns, which can … …Journal of Computer Science, Vol. 22, Issue 11 · 14 Oct 2026 · 566 accessesView PDFCite
Research ArticleOpen accessIn the abstractEpigenetic Regulation of Extracellular Matrix Remodeling in Skin Aging: Mechanisms and InteractionsJiguang Yang, Yusong Shi, Xiaoqing YanSkin aging results from complex interactions between genetic factors, environmental stressors, and epigenetic modifications that regulate extracellular matrix (ECM) remodeling. Accumulation of senescent cells impairs tissue regeneration through mechanisms including telomere shortening, reactive oxygen species accumulation, and ultraviolet (UV) radiation exposure. While epigenetic pathways regulate skin homeostasis, regeneration, and senescence, the specific epigenetic changes occurring during UV exposure, chronological aging, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,458 accessesView PDFCite
Review ArticleOpen accessIn the abstractUnraveling the Mechanisms of Plant Structural Defenses against Insect PestsAroni Preya Biswas, Roksana Al Nafiu Insha, Md. Khairul Mazed et al.Plants employ a variety of physical, chemical, and genetic strategies to defend against herbivore attacks. These biochemical defense mechanisms are complex and dynamic, encompassing both direct and indirect responses. Defense-related chemicals, whether constitutive or induced by herbivore damage, significantly influence herbivore feeding behavior, growth, and survival. Plant defense systems impact herbivore nutrition, development, and survival, highlighting the importance of chemical … …OnLine Journal of Biological Sciences, Vol. 25, Issue 1 · 7 Jan 2025 · 5,793 accessesView PDFCite
Research ArticleOpen accessIn the abstractProposal of a Genome Editing System for Genetic Resistance to Tomato Spotted Wilt VirusFederico Martinelli, Giovanni Grillone, Filippo SgroiViruses provoke considerable economical losses in agriculture. New molecular approaches to develop genetic resistance based on translational genomics and precision genetic modifications are highly expected. The type II Clustered, Regularly Interspaced Palindromic Repeats (CRISPR) system including Cas9 nuclease represent a promising and very powerful tool to specifically modulate the expression and activity of genes involved in biotic stress responses. In … …American Journal of Applied Sciences, Vol. 11, Issue 11 · 7 Jan 2015 · 7,685 accessesView PDFCite
Research ArticleOpen accessIn the abstractTRANSCRIPTION ACTIVATOR-LIKE EFFECTOR NUCLEASES-AMAZING TOOL FOR GENOME EDITINGAvantika Singh, Vivek Pratap SinghTranscription Activator-Like Effector Nucleases (TALENs) are used to cut specific target DNA sequence in order to knock out a gene or to change its sequence. They are formed by the fusion of TALE protein serving as DNA binding domain along with non-specific DNA cleaving nucleases. Its specificity towards DNA bases in the target sequence is derived from the structure of … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 4 Sep 2013 · 7,997 accessesView PDFCite
Research ArticleOpen accessIn the abstractOPTIMIZATION OF TEST CASES BY PRIORITIZATIONT. Prem Jacob, T. RaviRegression testing is testing the software in order to make sure that the modification made on the program lines does not affect the other parts of the software, it is in maintenance phase and accounts for 80% of the maintenance cost and thus optimizing regression testing is one of the prime motives of software testers. Here we take the advantage … …Journal of Computer Science, Vol. 9, Issue 8 · 4 Jul 2013 · 7,603 accessesView PDFCite
Research ArticleOpen accessIn the abstractMultimodal Biometric-based Secured Authentication System using SteganographyB. Shanthini, S. SwamynathanProblem statement: The main challenge in the design of a security system for high security mobile ad OC network is how to prevent the attacks against data modification and authentication. Approach: In this novel proposed system the messages communicated between the users are encrypted by the cancellable cryptographic key generated from fingerprint features of the receiver by applying genetic operators … …Journal of Computer Science, Vol. 8, Issue 7 · 7 May 2012 · 7,279 accessesView PDFCite