2 articles for “EP4 Receptor”

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HypothesisOpen accessIn the keywordsCJ-023,423 (Grapiprant) a Potential Novel Active Compound with Antihyperalgetic Properties for Veterinary PatientsMario GiorgiCompanion animals are now living longer and so are more commonly manifesting age- and pain-related disease. Nonsteroidal anti-inflammatory drugs are the most used drug in osteoarthritis and inflammatory pain of various aetiologies. Despite their safety profiles have been amended from the COX-non selective to the COX-2 selective inhibitor class, some adverse effects are still of concern especially in long term … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 2 · 14 May 2015 · 8,874 accessesView PDF Cite

Research ArticleOpen accessIn the abstractNovel LC-MS/MS Method for CJ-023423 (Grapiprant) Determination in Rabbit PlasmaElena Baralla, Virginia De Vito, Maria Vittoria Varoni et al.Grapiprant is a new anti-inflammatory drug that preferentially targets the EP4 receptor of prostaglandin E2 limiting the wide range of adverse effects caused by the classical non steroideal anti-inflammatory drugs. The aim of this study was to develop and validate a new, simple, sensitive and rapid Liquid Chromatography tandem Mass Spectrometry method (LC-MS/MS) in order to quantify this novel drug … …American Journal of Animal and Veterinary Sciences, Vol. 13, Issue 2 · 24 May 2018 · 7,988 accessesView PDF Cite