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27 results for “Drug Interactions”
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Review ArticleOpen accessPhrase in the titleDrug Interactions Pharmacology: A Narrative ReviewLívia Maria Barbosa Neves, Louryanne de Castro Silva, Mônica Thalia Brito de Melo et al.Thesimultaneous prescription of multiple drugs used in therapeutic schemes canresult in drug interactions, with desirable or undesirable effects. Thus, theobjective of this study was to describe the mechanisms involved in clinicallyrelevant drug interactions. This is a narrative review in which studiespublished in PUBMED and the VHL were searched in the following databases:MedLine, Lilacs, and Scielo. The search was performed in … …American Journal of Pharmacology and Toxicology, Vol. 17, Issue 1 · 25 Oct 2022 · 9,157 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDFCite
Research ArticleOpen accessIn the abstractUnveiling the Potential of Dombeya buettneri K.Schum As a Drug Agent: Molecular Docking of Compounds With Enzymes Linked to Diabetes and Neurodegenerative DiseaseEsther Emem Nwanna, Samuel Chima Ugbaja et al.This study investigated the mechanisms of Dombeya buettneri (snowball leafy) extracts on diabetes, hypertension, and neurodegenerative diseases. It compared extracts obtained using steep water (a by-product of corn wet milling) and aqueous water. The extracts were analyzed for total phenol, total flavonoid content, antioxidant activities such as FRAP, ABTS, NO, DPPH, iron-induced lipid peroxidation assay, degradation of deoxyribose (Fenton’s reaction), … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 1 Feb 2026 · 2,025 accessesView PDFCite
Research ArticleOpen accessIn the abstractComputational Validation of Selected Compounds from the GC-MS Profile of Abies numidica Essential Oil and their Antibacterial EffectsAbdelouahab Dehimat, Boudjellal Fayssal, Salem Dounya et al.This work examined the chemical composition of the Algerian endemic tree Abies numidica (Pinaceae) and investigated the antibacterial potential of three major constituents of its essential oil-Santene, Linalyl acetate, and 2,6-Octadiene-2,6-dimethyl-as reported in previously published GC-MS data. Computational antibacterial screening was carried out by docking the selected compounds onto the bacterial proteins 5Z9N (Staphylococcus aureus) and 3AQC (Micrococcus luteus). Molecular … …Current Research in Bioinformatics, Vol. 10, Issue 1 · 24 Jan 2026 · 2,939 accessesView PDFCite
Research ArticleOpen accessIn the abstractComparative Evaluation of Synergistic Antibacterial Effects in Blended Essential Oil against Gram-Positive and Gram-Negative PathogensMin-Gi Kwon, Jae Kyung KimThe rising emergence of multidrug-resistant bacteria has heightened the search for novel antibiotic agents. Essential Oils (EOs) are complex combinations of volatile organic compounds generated by plants, with many exhibiting significant antimicrobial properties. This study evaluates the antibacterial movement of single and blended EOs against representative gram-positive bacteria Staphylococcus aureus and Methicillin-Resistant S. aureus (MRSA) and gram-negative bacteria Escherichia coli … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 2 · 7 Jul 2025 · 5,481 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn silico and in vitro Structural Analysis on the Interaction of Calmodulin and Calmodulin-Binding Motif of FKBP35 from Plasmodium knowlesiSazlinawatie Aladin, Cahyo Budiman et al.FK506-binding protein 35 (FKBP35) is a peptidyl-prolyl cis-trans isomerase found in Plasmodium knowlesi, a zoonotic malaria parasite responsible for concerning cases of malaria infection in East Malaysia. This protein contains a segment known as the calmodulin-binding motif (Pk-CBM), which is predicted to facilitate interaction with calmodulin from P. knowlesi (Pk-CaM). Although this interaction is considered promising for future antimalarial drug … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 10 Mar 2025 · 4,846 accessesView PDFCite
Research ArticleOpen accessIn the abstractMechanism Analysis of Artemisinin and Artesunate as Lung Cancer Therapy Agents Through in Silico MethodDidik Harmoko, Vivitri Dewi Prasasty, Adi YulandiSeveral in vitro studies have focused on the ability of artemisinin and its derivatives to suppress lung cancer cells, but there are still many biological processes and mechanisms, such as the interactions between the active compounds (ligands) and receptors that are not well understood and require further research. Drug targeting for lung cancer will be more precise and the inhibition … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 15 Feb 2024 · 6,144 accessesView PDFCite
Review ArticleOpen accessIn the abstractSelf-Assembly Peptides-a ReviewOlushola Sunday Ayanda, Olusola Solomon Amodu, Cyprian Yameso Abasi et al.Self-assembling of peptides is a spontaneous process by which peptides are self-organized to form well-ordered structures by intramolecular and intermolecular interactions.This process is controlled by the balance of the forces (attractive andrepulsive) within the peptide molecules. Notable methods used for the synthesis of self-assembly peptides are solid-phase synthesis, liquid-phase synthesis,recombinant technology, and the use of external fields. The self-assembled nanostructure-based … …OnLine Journal of Biological Sciences, Vol. 22, Issue 3 · 12 Aug 2022 · 5,739 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Extent of Community Awareness Using Natural Element’s Instead of Using Chemical DrugsMeliz Yuvalı, Ismail Bakır, Ilker EtikanAlternative medicine it is a medicine that is not taught in traditional medicine. It is based on ancient historical foundations and different experiments in treatment without building it on the basis of scientific teacher. Alternative medicine is used in many peoples, especially non-developed peoples. Alternative medicine is used as primary medicine. The evidence of poor quality and knowledge about the … …Current Research in Biostatistics, Vol. 7, Issue 2 · 25 Oct 2017 · 8,033 accessesView PDFCite