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41 articles for “Drug Evaluation”
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Review ArticleOpen accessIn the keywordsLong Way of Evaluating Niacin for Atherosclerosis TreatmentAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Elizaveta Mikhailovna Pleshko et al.Atherosclerosis is a significant public health challenge, as it is closely associated with a wide range of cardiovascular diseases and complications. Despite its grave implications, the timely detection and treatment of atherosclerosis remain complex tasks due to the intricate pathogenesis involved, which encompasses numerous processes and mechanisms. Extensive research has been conducted to investigate various therapeutic methods and drugs aimed … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 24 Feb 2024 · 5,122 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of an Intelligent Electronic Prescription Ontology Using Open Source Tools: A Botswana Case StudyTshiamo Sigwele, Eunice Okon, Tshepiso Mokgetse, Onkemetse TshenyegoHealthcare interoperability in Botswana is hindered by fragmented information exchange across public and private providers, resulting in prescription conflicts, duplicated treatment, and delayed care. In prior work, we developed the Intelligent Electronic Prescription Ontology (IEPO), an open-source OWL 2 ontology for semantically standardized prescription data exchange. Although IEPO was previously validated using competency question-driven metrics (recall, precision, and F1-score), those … …Journal of Computer Science, Vol. 22, Issue 10 · 29 Sep 2026 · 500 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractSemSimp: A Parametric Method for Evaluating the Semantic Similarity of Digital ResourcesAntonio De Nicola, Anna Formica, Ida Mele, Francesco TaglinoAbioui, H., Idarrou, A., Bouzit, A., & Mammass, D. (2018). Towards a Novel and Generic Approach for OWL Ontology Weighting. Procedia Computer Science, 127, 426–435. https://doi.org/10.1016/j.procs.2018.01.140 Adhikari, A., Dutta, B., Dutta, A., Mondal, D., & Singh, S. (2018). An intrinsic information content-based semantic similarity measure considering the disjoint common subsumers of concepts of an ontology. Journal of the Association for … …Journal of Computer Science, Vol. 20, Issue 8 · 27 May 2024 · 5,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractVirtual Screening of CPP Conjugated Peptide as QcrB BCC Protein Inhibitors of Mycobacterium tuberculosis BacteriaMuhammad Ihsan Muttaqin, Manaman Huang, Usman Sumo Friend TambunanTuberculosis is a global leading cause of death, just below COVID-19 and ranked above HIV. This disease is caused by a pathogen called Mycobacterium tuberculosis, which spreads easily through the air and is known to remain latent in most people's bodies, about a quarter of the world's population. The current problems with TB also include two main concerns: The official … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 14 Mar 2024 · 5,518 accessesView PDFCite
Research NotesOpen accessIn the abstractAdvance in the Diagnostics of Mare Pregnancy and Assessing the Activity of Gonadotropin in Serum of in-Foal MareKaliya Kudaikulovna Yerkekulova, Nuradin Alibayev, Yusupzhan Artykovich Yuldashbayev et al.Research works on the improvement of mare pregnancy diagnostics and evaluation of biological activity of gonadotropic preparation based on the use of enzyme-linked immunosorbent assay were carried out. As the result of diagnostics and evaluation, effective producers as donors for obtaining gonadotropic preparation among the Kazakh population of mares with type “zhabe”, the animal units of 60 days with their … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 7 Mar 2024 · 4,828 accessesView PDFCite
Research ArticleOpen accessIn the abstractDataset of Selected Medicinal Plant Species of the Genus Brachylaena: A Comparative Application of Deep Learning Models for Plant Leaf RecognitionAvuya Deyi, Arnaud Nguembang Fadja, Eleonora Deborah Goosen et al.Since several active pharmaceutical ingredients are sourced from medicinal plants, identifying and classifying these plants are generally a valuable and essential task during the drug manufacturing process. For many years, identifying and classifying those plants have been exclusively done by experts in the domain, such as botanists and herbarium curators. Recently, powerful computer vision technologies, using deep learning or deep … …Journal of Computer Science, Vol. 19, Issue 11 · 17 Oct 2023 · 6,219 accessesView PDFCite
EditorialOpen accessIn the abstractNaloxone as a Harm Reduction Initiative: Misinterpretations of ResearchRichard R. MassattiIn the American Medical Journal, Annahita Beheshti and colleagues review the literature on naloxone use for opioid overdose in West Virginia (Beheshti et al., 2015). The authors cite several of my publications in support of their views on naloxone (Massatti, 2013; Massatti et al., 2014), but many of these citations misinterpret my work by using it to present a counterargument … …Current Research in Medicine, Vol. 7, Issue 1 · 9 Apr 2016 · 8,029 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite