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64 results for “Dose-response”
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Research ArticleOpen accessPhrase in the titleHormetic and Non-Hormetic Dose-Response Functions in Stress Effects on Memory and Synaptic Plasticity: Issues and MechanismsPhillip R. Zoladz, David M. DiamondOver a century of behavioral research has shown that stress can exert both positive and negative effects on memory. We have explored the idea that the complex effects of stress on learning and memory can be characterized by hormetic- and non-hormetic dose-response functions, in which stress may either stimulate or impair brain memory mechanisms, depending, in part, on the timing … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 8,184 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleNeuroprotection Afforded by GABA Against Oxygen-Glucose Deprivation-Induced Injury in Rat Cortical Brain Slices: An Hormetic Dose-Response EffectLorenzo Ricci, Massimo Valoti, Giampietro Sgaragli, Maria FrosiniThe aim of the present investigation was to assess neuroprotection exerted by GABA (100 nM-100 mM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue water content. Results demonstrate that GABA exerted neuroprotective effects according to a U-shaped, hormetic-like, concentration-response curve, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,166 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEffect of Dose-Response of Zinc and Manganese on Siderophores ProductionMehri Ines, Khessairi Amel, Turki Yousra et al.Problem statement: This study was conducted to find and determine whether the siderophores of the four environmental Pseudomonas spp. isolates possess a sequestering activity towards essential transition metals (Zn and Mn) other than iron. Approach: Four fluorescent Pseudomonads isolated from various environments, were characterized analytically (Isoelectric focusing), biologically (pyoverdine-mediated uptake) and genetically (16S rDNA sequencing). By means of spectrophotometric measurements, … …American Journal of Environmental Sciences, Vol. 8, Issue 2 · 10 Mar 2012 · 7,768 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleDose Response and Optical Properties of Dyed Poly Vinyl Alcohol-Trichloroacetic Acid Polymeric Blends Irradiated with Gamma-RaysSusilawati, Aris DoyanProblem statement: The effects of gamma irradiation on optical properties of cresol-red dyed Poly Vinyl Alcohol (PVA) blended with Trichloroacetic Acid (TCA) for possible use in dosimetry and measurement of radiation dose in gamma rays have been studied using both Raman spectroscopy and UV-Visible spectrophotometer method. Approach: The dosimeters are composed of Poly Vinyl Alcohol (PVA), Trichloroacetic Acid (TCA) at … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 8,088 accessesView PDFCite
Research ArticleOpen accessEvery word in the titletNOX (ENOX2) Target for Chemosensitization-Low-Dose Responses in the Hormetic Concentration RangeD. James Morre, Sara Dick, Elena Bosneaga et al.An emerging concept of cancer chemotherapy is that of chemosensitization. Most often applied to the treatment of drug-resistance cancers, chemosensitization has utility when such cancers are rendered drug sensitive through treatment with the sensitizing agent. A particularly striking example of chemosensitization is that encountered with the synthetic isoflavene phenoxodiol where patients with taxane- and/or platinum-resistant ovarian carcinoma once again become … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,568 accessesView PDFCite
Research ArticleOpen accessIn the keywordsEvaluating the Effect of Booster Dose of Hepatitis B Vaccine in Low-and Non-Responders Healthcare Workers and the Role of some Host-Related FactorsMojtaba Varshochi, Mehdi HaghdoostProblem statement: Hepatitis B comprises one of the major health problems worldwide. Health Care Workers (HCW) are a group at risk for Hepatitis B Virus (HBV) infection. Infection with hepatitis B virus has become a vaccine-preventable disease. Vaccination against Hepatitis B Virus infection (HBV) is safe and effective. The aim of this study is evaluation the immunologic response of booster … …American Journal of Immunology, Vol. 7, Issue 2 · 4 Nov 2011 · 7,542 accessesView PDFCite
Research ArticleOpen accessIn the keywordsDihydroartemisinin-Stimulated Hyperplasia of Rat Lung Smooth MusclesUtoh-Nedosa Uchechukwu AnastasiaProblem statement: Dihydroartemisinin was shown to produce two types of inhibitory effects on the cardiac muscles of rats. It was also shown to stimulate haemopoiesis in the lungs, liver, spleen, intestine and kidney of rats. This study attempted to find out the nature of the effect of oral dihydroartemisinin on the lungs of Wistar albino rats. Approach: The effects of … …American Journal of Applied Sciences, Vol. 9, Issue 2 · 8 Dec 2011 · 7,024 accessesView PDFCite
Research ArticleOpen accessIn the abstractMeta Analysis of Growth Performance of Broilers in Response to Dietary Cassava Leaf Meal InterventionChristian Anayo Mbajiorgu, Ifeanyi Princewill OgbuewuThe use of Cassava Leaf Meal (CLM) in broiler diets has gained attention due to its high crude protein content (24-35%) and other valuable nutrients. Therefore, the objective of this meta-analysis was to assess the impact of diets with and without CLM on broiler growth performance. Search performed on four bibliographic databases produced 584 articles of which 11 were used … …American Journal of Animal and Veterinary Sciences, Vol. 21, Issue 3 · 30 Sep 2026 · 578 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Dietary Emamectin Benzoate at Recommended and Overdose Levels on the Pathophysiological Responses and Tolerability of Oreochromis niloticus at Fry StageJasmine Singha, Thangapalam Jawahar Abraham, Satyen Kumar Panda, Prasanna Kumar PatilEmamectin Benzoate (EB) has been recommended as a feed additive for the control of fish ectoparasites. This investigation examined the impact of dietary EB on physiological responses, antioxidant defence mechanisms, and histopathological changes in key organs, and on the kinetics of residue deposition and elimination in the muscle of Oreochromis niloticus fry. Fry were administered EB feeds at 50 µg … …American Journal of Pharmacology and Toxicology, Vol. 20, Issue 1 · 1 Jul 2026 · 1,469 accessesView PDFCite