75 articles for “Disease Progression”

Research ArticleOpen accessPhrase in the titleAn Integrated Disease Progression Model to Analyze Electronic Health Records With Multimodal Datasets Using Deep Learning TechniquesThulaganyo Dimakatso, Venumadhav Kuthadi, Rajalakshmi Selvaraj, Othapile DinakenyaneIn contemporary clinical environments, precisely simulating the emergence of disease is an intricate task owing to heterogeneously derived data and variability in the record of diagnoses. The research presents a stable classification model that integrates image data with formalized patient data to track patterns in disease through various stages. The suggested approach combines a multi-stage analytical methodology that includes systematic … …Journal of Computer Science, Vol. 22, Issue 2 · 19 Feb 2026 · 1,678 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleRole of Hematological and Alternate Markers in Human Immunodeficiency Virus Disease ProgressionK. V. Ramana, Jagadeeshwara Chary, V. Sabitha et al.Problem statement: The knowledge of HIV infection has expanded tremendously which has led to significant improvement in the treatment, leading to decrease in morbidity and mortality. Considering the limitations in using CD4+T-cell counts and HIV RNA viral load as markers in the HIV disease progression, physicians treating the HIV patients now look for alternate markers that predict HIV disease progression … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,372 accessesView PDF Cite

Research ArticleOpen accessPhrase in the titleCo-expression of Apoptosis-Related Molecules on Activated CD8+ CD38+ T-cells is Associated with HIV-1 Disease ProgressionJosé W. Rodríguez, Luis A. Rodríguez, Griselle Font et al.CD8+ T cells play a major role in controlling HIV-1 infection through the release of soluble lytic and non-lytic antiviral factors. Their decrease or defective function contributes to the HIV-1 disease progression. HIV-1 disease progression has been associated with a remarkable increase of CD38 expression on CD8+ T-cells. It has been also documented that a significant distribution of HIV-specific CD8+T-cells … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,009 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsMULTI-STATE MODELS OF HIV/AIDS BY HOMOGENEOUS SEMI-MARKOV PROCESSZelalem Getahun DessieMulti-state stochastic models are useful tools for studying complex dynamics such as chronic diseases. The purpose of this study is to determine factors associated with the progression between different stages of the disease and to model the progression of HIV/AIDS disease of an individual patient under ART follow-up using semi-Markov processes. A sample of 1456 patients has been taken from … …Current Research in Biostatistics, Vol. 4, Issue 2 · 11 Aug 2014 · 8,209 accessesView PDF Cite

Research ArticleOpen accessIn the abstractMaternal and Fetal Outcome of COVID Positive Antenatal Women Treated With Tocilizumab in a Tertiary Care Center an Observational Cohort StudyJaimie T Jacob, S Lakshmi Vinodh, Aravind R et al.Tocilizumab, an IL-6 receptor inhibitor, halts the inflammatory stage of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. However, there is little information on Tocilizumab's effects on antenatal women and new born. This study aims to assess the effects of Tocilizumab in treating antenatal women with severe COVID infection. To assess and compare the maternal and fetal outcomes of COVID … …American Journal of Infectious Diseases, Vol. 22, Issue 1 · 14 Sep 2026 · 654 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAdipokines Overview: The Major Component of Immune DysregulationAnastasia Vladimirovna Poznyak, Daria Dmitryevna Borodko, Stanislav Anatolievich Antonov et al.Purpose of Review: Obesity is increasingly recognized as an immune endocrine disorder rather than only a metabolic condition. This review critically examines how adipokines particularly adiponectin, resistin, adipsin, and chemerin mediate the interplay between obesity and autoimmunity. Unlike previous reviews that broadly surveyed cytokines, our focus is on comparative roles of specific adipokines across multiple autoimmune diseases. Recent Findings: Evidence … …OnLine Journal of Biological Sciences, Vol. 26, Issue 3 · 11 Aug 2026 · 879 accessesView PDF Cite

Literature ReviewOpen accessIn the abstractIntracranial Atherosclerotic Disease: Treatment Potential and Diagnostic OpportunitiesAnastasia Vladimirovna Poznyak, Victoria Alexandrovna Khotina, Anton Yuvenalievich Postnov et al.Atherosclerosis, characterized by the accumulation of atherosclerotic plaques within large arteries, substantially increases the risk of cardiovascular events, including ischemic stroke. Intracranial atherosclerotic disease (ICAD) represents a particularly significant clinical threat given its strong association with ischemic stroke across multiple intracranial arterial territories. This review provides a comprehensive analysis of the pathogenesis, diagnosis, and management of intracranial atherosclerosis. Special attention … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 5 May 2026 · 1,093 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAn AI-Powered Integrated Care Model Combining Traditional Chinese Medicine and Western Medicine for Personalized Alzheimer’s Disease ManagementShurong Li, Yiming Chen, Jin Xu et al.Alzheimer's Disease (AD) gradually reduces memory and cognition. While Western medicine focuses on pharmacological treatments, it frequently ignores holistic factors such as mood and digestion. Traditional Chinese Medicine (TCM) addresses these issues through a wellness-oriented approach. However, the combination of both systems in patient care is uncommon. Current Alzheimer's disease treatments are often siloed, relying solely on Western or alternative … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 16 Feb 2026 · 2,063 accessesView PDF Cite

Literature ReviewOpen accessIn the abstractSigns of Predisposition to Atherosclerosis in Fetal DevelopmentAnastasia Vladimirovna Poznyak, Igor Alexandrovich Sobenin, Elizaveta M. Pleshko et al.Atherosclerotic Cardiovascular Disease (ASCVD) remains a significant global health concern, contributing to a substantial number of deaths worldwide. The etiology of this condition is multifaceted, influenced by a plethora of genetic and environmental determinants. Notably, certain risk factors and predictive markers associated with ASCVD may already present or emerge during the prenatal or neonatal period. Early recognition of these markers … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 15 Feb 2026 · 1,302 accessesView PDF Cite

Research ArticleOpen accessIn the abstractOptimized Feature Selection for Kidney Ultrasound Image Classification Using Binary Coati Weighted Mean Vector AlgorithmFizhan Kausar, Ramamurthy B.The analysis of medical images presents many challenges, especially when making precise diagnoses. In pediatric Chronic Kidney Disease (CKD), early identification is critical because of its gradual progression to significant kidney failure. This study proposes a diagnostic framework for pediatric ultrasound image classification that incorporated machine learning and advanced feature selection methods. This approach is divided into four stages: Preprocessing, … …Journal of Computer Science, Vol. 21, Issue 12 · 22 Jan 2026 · 1,563 accessesView PDF Cite