7 results for “Cytochrome P450”

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Research ArticleOpen accessIn the keywordsCopper (I)-Nicotinate Promotes Gene Expression of CYPs that Produce M1 and Q1 in Aflatoxicosed RatsMohammed Salah, Laila Mostafa, Tahia H. Saleem et al.Aflatoxin-contaminated food poses a serious risk to both human and animal health. Copper (1)-nicotinate (Cu+-nicotinate) complex potentiated the prophylactic effect against chronic aflatoxicosis in the experimental animals through the synthesis of less toxic metabolites M1 and Q1 which are easily excreted in urine. To investigate the action of the safety Cu+-nicotinate complex on gene expression of Cytochrome 450 (CYP450) system, … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 28 Jan 2020 · 8,152 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEffect of Heat Stress on the Expression of HSP70, UCP3 and CYP450 Genes in Liver; Longissimus Dorsi and Semitendinosus Muscle of Growing PigsV. Montesinos-Cruz, M. Cota, L. Buenabad et al.High Ambient Temperature (AT) provokes Heat Stress (HS) in animals, which is characterized by increased body temperature, Reactive Oxygen Species (ROS) production and cell damage. Uncoupling Proteins (UCP) may contribute to dissipate body heat, cytochrome P450 (CYP3A4) reduces ROS and Heat Shock Proteins (HSP) prevent protein denaturalization. This study analyzed the expression of HSP70, UCP3 and CYP3A in liver, Longissimus … …American Journal of Animal and Veterinary Sciences, Vol. 14, Issue 4 · 24 Oct 2019 · 7,867 accessesView PDF Cite

Research ArticleOpen accessIn the abstractINTERVENTION OF PHARMACOGENETIC PROFILING IN THERAPEUTICS OF KASHMIRI POPULATION, A LESSON LEARNED FROM CYP3A5*3 VARIANTAshaqullah Bhat, Aadil Wani, Rajinder Kaur et al.Human Cytochrome P450 3A, a variant of Cytochrome P-450- dependent monooxygenases is a major drug metabolizing enzyme. CYP3A has evolved to catalyze the biotransformation of its substrate. A great deal of inter-individual variation in expression levels exists for CYP3A5 gene. The common polymorphism in CYP3A5 that induces a cryptic splice site has been shown to cause a significant reduction in … …OnLine Journal of Biological Sciences, Vol. 14, Issue 3 · 10 Jul 2014 · 7,215 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPOTENTIAL AMELIORATIVE ROLE OF N-ACETYLCYSTEINE AGAINST TESTICULAR DYSFUNCTION INDUCED BY TITANIUM DIOXIDE IN MALE ALBINO RATSAhmed Farag El-Kirdasy, Mohamed Abdo Nassan, Ahmed Abdel Aziz Baiomy et al.In this study, we examined the ameliorative action of N-Acetylcysteine (NAC) against Titanium Dioxide (TiO2) induced testicular degeneration in albino rats. Adult male albino rats were given saline as a control group, TiO2 (1200 mg kg-1 BW), NAC (100 mg kg-1 BW) and co-treatment of NAC and TiO2 as a protective group for 3 months. Testicular tissues were extracted for … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 31 Dec 2013 · 7,900 accessesView PDF Cite

Research ArticleOpen accessIn the abstractConstitutive Androstane Receptor Dependent and Independent Modulation of CYP3A2, CYP1A2 by Phenobarbital and Fibrate in Rats’ LiverMohamed Mohamed Ahmed, Mustafa Shukry, Zein Shaban Ibrahim et al.Cytochrome P450 enzymes, CYP3A and CYP1A are major drug metabolizing enzymes in the liver. CYP3A enzymes have a major role in the metabolism of 30-40% of all used drugs. CYP1A2 is a key enzyme having an important role in the metabolic clearance of 5% of currently marketed drugs. CYP1A2 participates in the metabolic activation of chemical mutagens in cooked food, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,381 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAqueous Stem Bark Extract of Spathodea campanulata (P. Beauv) Modulates Carbon Tetrachloride Induced Hepatic Damage in RatsCharles Ansah, Phyllis Elsie Dadzeasah, Emmanuel AsiamahThe objective of the present study was to evaluate the hepatoprotective and curative potential of the aqueous extract of the stem bark of Spathodea Campanulata (SCE) in a carbon tetrachloride-induced model of hepatotoxicity in rats. Rats pre-treated with 625 mg kg-1, 1250, 2500 mg kg-1 or silymarin (50 mg kg-1) p.o for 3 days were intoxicated with CCl4 (1 mL … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 27 May 2013 · 8,999 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDifferential Gene Expression in Zebrafish (Danio rerio) Following Exposure to Gaseous Diffusion Plant Effluent and Effluent Receiving Stream WaterBen F. Brammell, Andrew J. WiggintonProblem statement: The expression of six genes known to serve as bioindicators of environmental stress were examined using real-time quantitative PCR in liver tissue extracted from zebrafish (Danio rerio, Hamilton) exposed to effluent and effluent containing stream water associated with the Paducah Gaseous Diffusion Plant (PGDP). Approach: The PGDP, the only active uranium enrichment facility in the US, is located … …American Journal of Environmental Sciences, Vol. 6, Issue 3 · 30 Jun 2010 · 7,770 accessesView PDF Cite