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8 results for “Cyclooxygenase-2 (COX-2)”
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Research ArticleOpen accessIn the keywordsDetection and Localization of Anti and Pro-apoptotic mRNA Genes in Human Colorectal Cancer Using in situ RT-PCRMohd. Nazil Salleh, Boo Siaw Shi, Wan Khairuzzaman Wan Ramli et al.Problem statement: Recent studies using conventional Polymerase Chain Reaction have shown that anti-apoptotic (Cyclooxygenase-2, COX-2 and Nuclear Factor-κB, NF-κB) and proapoptotic mRNA (Bax and Bad) are involved in the tumorigenesis of colorectal cancer. The aim of this study was to localize the expression of anti and pro-apoptotic mRNA genes using Reverse Transcription in situ Polymerase Chain Reaction (RT in situ … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,441 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSitagliptin Impairs Healing of Experimentally Induced Gastric Ulcers Via inhibition of iNOS and COX-2 ExpressionAmina Unis, Eman AbdelzaherGastric ulcer healing is a complex process that is regulated by several promoting factors including COX-2 and iNOS. Diabetes mellitus is usually associated with delayed gastric ulcer healing. Hence, the current study was designed to investigate the effect of sitagliptin (dipeptidyl peptidase-4 inhibitor) on gastric ulcer healing and expression of iNOS and COX-2 in rat stomach.The study was conducted on … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 3 · 4 Sep 2013 · 7,436 accessesView PDFCite
Research ArticleOpen accessIn the abstractFerulic Acid in Chinese Herbal Medicine: Regulating Autophagy for Oxidative Damage ReductionZhiyuan Lv, Qiaozhen Zhao, Shanbin Chen et al.Ferulic Acid (FA) is the primary functional component in herbal plants and traditional fermented foods. To comprehend the mechanism of action of ferulic acid, in terms of its regulation of autophagy, antioxidants and the inhibition of inflammatory pathways, the study was conducted. Oxidatively damaged human-derived hepatocytes were treated with FA and the processing concentration of FA is from 50-800 μm. … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 2 · 1 Jun 2024 · 5,483 accessesView PDFCite
HypothesisOpen accessIn the abstractCJ-023,423 (Grapiprant) a Potential Novel Active Compound with Antihyperalgetic Properties for Veterinary PatientsMario GiorgiCompanion animals are now living longer and so are more commonly manifesting age- and pain-related disease. Nonsteroidal anti-inflammatory drugs are the most used drug in osteoarthritis and inflammatory pain of various aetiologies. Despite their safety profiles have been amended from the COX-non selective to the COX-2 selective inhibitor class, some adverse effects are still of concern especially in long term … …American Journal of Animal and Veterinary Sciences, Vol. 10, Issue 2 · 14 May 2015 · 8,874 accessesView PDFCite
Research ArticleOpen accessIn the abstractPossible Therapeutic Role of Jasonia Candicans and Jasonia Montana Extracts in the Regression of Alzheimer’s Disease in Experimental ModelHanaa H. Ahmed, Hoda F. Booles, Wagdy K.B. Khalil et al.The present article aimed to investigate the potential role of the ethanolic extracts of the aerial parts of Jasonia candicans and Jasonia montana in management of Alzheimer’s Disease (AD) in experimental model. Supplementation of drinking water AlCl3 (0.3%) for 16 weeks induced AD in male rats with siginifcant increase in brain Acetylcholinesterase (AchE) activity, Tumour Necrosis Factor (TNF-α), Transforming Growth … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 2 · 20 Jun 2013 · 7,830 accessesView PDFCite
Research ArticleOpen accessIn the abstractInfluence of Heirloom Tomato Polyphenol Extracts on Expression of Inflammation Genes in BovineKwaku Gyenai, Nona Mikiashvili, Hamid Ismail, Mulumebet WorkuThe effect of tomato on diseases of economic importance continues to be of broad interest. To evaluate these relationships, the effect of crude extracts of Cherokee purple tomato on pro-inflammatory genes and cytokines were evaluated. Neutrophils from three Holstein Fresian cows were treated with Phosphate Buffered Saline (PBS) or E. coli O111-B4 Lipopolysaccharide (LPS). Treated cells were exposed to different … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 3 · 25 Aug 2012 · 8,377 accessesView PDFCite
Research ArticleOpen accessIn the abstractLemon Pepper Fruit Extract (Zanthoxylum acanthopodium DC.) Suppresses the Expression of Inflammatory Mediators in Lipopolysaccharide-Induced Macrophages In VitroYanti, Theodorus Eko Pramudito, Nerissa Nuriasari, Katarina JulianaProblem statement: Lemon pepper fruits (Zanthoxylum acanthopodium DC.; Rutaceae) have been used as a traditional source against stomach ache by Batak people in North Sumatera province, Indonesia. However, its scientific evidence for treatment of inflammatory disorders particularly gastritis has not been reported. Approach: Here, we investigated the inhibitory effects of Lemon Pepper Fruit Extract (LPFE) against inflammatory biomarkers by conducting … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 4 · 14 Feb 2012 · 9,581 accessesView PDFCite
Research ArticleOpen accessIn the abstractTherapeutic Effects of Phyllanthus Species: Induction of TNF-α-mediated Apoptosis in HepG2 Hepatocellular Carcinoma CellsSripathi M. Sureban, Dharmalingam Subramaniam, Paramasivam Rajendran et al.Phyllanthus species, especially P. amarus is a medicinal plant with hepatoprotective activity, believed to occur in part by inhibiting hepatitis B virus function. The pathogenesis mechanism of viral hepatitis is closely related to hepatocyte necrosis apoptosis. The aim of our study was to investigate the in vitro effects of extracts from three Phyllanthus species, P. urinaria, P. amarus and P. … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2007 · 9,005 accessesView PDFCite