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Research ArticleOpen accessPhrase in the titleEffect of pH on the Conformation and Biological Activity of Clostridium septicum Alpha-toxin, a Pore-forming HemolysinB.M. Hang'ombe, T. Kohda, M. Mukamoto, S. KozakiThe effects of pH on the pore-forming Clostridium septicum alpha-toxin that causes myonecrosis was assessed at pH 5.0, 7.0 and 9.0 by measuring circular dichroism and its biological activity. Incubation of the toxin at pH 5.0 increased the hemolytic activity measured in murine red blood cells. On the other hand, incubation of the toxin at pH 9.0 drastically reduces the … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 2 · 30 Jun 2007 · 6,902 accessesView PDF Cite

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