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53 articles for “Clinical Trials”
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Research ArticleOpen accessPhrase in the titleGeneral Linear Models in a Missing Outcome Environment of Clinical Trials Incorporating with Splines for Time-Invariant Continuous AdjustmentMinjeong Park, Dejian Lai, Xianglin L. Du et al.Missing data is a common occurrence in longitudinal studies of health care research. Although many studies have shown the potential usefulness of current missing analyses, e.g., (1) Complete Case (CC) analysis; (2) imputation methods such as Last Observation Carried Forward (LOCF), multiple imputations, Expectation-Maximization algorithm approach; and (3) methods using all available data such as linear mixed model and generalized … …Current Research in Biostatistics, Vol. 5, Issue 1 · 18 Aug 2015 · 7,402 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleModeling Heterogeneity in Phase II Clinical TrialsChristopher N. Barnes, Shesh N. RaiProblem statement: The common assumption in non-randomized Phase II clinical trials is a homogeneous population with homogeneous response. This assumption is at odds with many trials today; a heterogeneous response due to the existence of subgroups. Approach: In order to examine the effects of heterogeneity on the trial outcome, a systematic platform is developed to quantify the range and classes … …Current Research in Biostatistics, Vol. 1, Issue 1 · 30 Jun 2010 · 10,131 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleA Bayesian Adaptive Design for Combination of Three Drugs in Cancer Phase I Clinical TrialsMourad Tighiouart, Quanlin Li, Steven Piantadosi, Andre RogatkoWe describe a Bayesian adaptive design for early phase cancer trials of a combination of three agents. This is an extension of an earlier work by the authors by allowing all three agents to vary during the trial and by assigning different drug combinations to cohorts of three patients. The primary objective is to estimate the Maximum Tolerated Dose (MTD) … …Current Research in Biostatistics, Vol. 6, Issue 1 · 25 Aug 2016 · 8,426 accessesView PDFCite
Research ArticleOpen accessPhrase in the titlePlacebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children with Chronic Respiratory Problems: III. Clinical FindingsVetvicka Vaclav, Richter Josef, Svozil Vladimir et al.The role of glucan in stimulation of immune reactions has been studied for decades. In this report we focused on the effects of orally administered glucan in children with chronic respiratory problems. We measured the physical endurance using a 6MWT test and the levels of eNO in 50 children aged 8-12 years and evaluated the effects of 100 mg/d oral … …American Journal of Immunology, Vol. 9, Issue 3 · 20 Aug 2013 · 9,030 accessesView PDFCite
Research ArticleOpen accessPhrase in the titlePlacebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children with Chronic Respiratory Problems: Antibody ProductionVetvicka Vaclav, Richter Josef, Svozil Vladimir et al.The role of glucan in stimulation of immune reactions has been well-established. In this report, we focused on the antibody production in glucan-supplemented children with chronic respiratory problems. We measured the levels of salivary IgA, IgM and IgG in 40 children aged 8-12 years and evaluated the effects of 100 mg d-1 oral dose of glucan. We found a significant … …American Journal of Immunology, Vol. 9, Issue 2 · 5 Jun 2013 · 10,468 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRandomized Clinical Stroke Trials in 2009Meheroz H. RabadiProblem statement: Stroke ranks as the leading cause of serious, long-term disability and death world-wide. It is estimated direct and indirect cost of stroke for 2009 was $68.9 billion. Approach: The objective of this review was to examine the effectiveness of emerging pharmacotherapy’s in patients with acute (≤2 weeks), sub-acute (2-12 weeks) and chronic (≥12 weeks) stroke studied in Randomized … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 7,250 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRandomized Clinical Stroke Trials In 2008Meheroz H. RabadiProblem statement: Stroke ranks as the third leading cause of death and the leading cause of serious, long-term disability; estimated direct and indirect cost of stroke for 2009 was $68.9 billion. Approach: The objective of this review was to examine the effectiveness of emerging pharmacotherapies in patients with acute (≤2 weeks), sub-acute (2-12 weeks) and chronic (≥12 weeks) stroke studied … …Current Research in Medicine, Vol. 1, Issue 1 · 30 Jun 2010 · 8,006 accessesView PDFCite
Research ArticleOpen accessIn the keywordsMesenchymal Stem Cell Transplantation for Retinal Degenerations and Dystrophies: Present and FutureEmma Ghazaryan, Shurong Wang, Yan Zhang et al.Retinal degenerations are the main causes of irreversible blindness in developed countries. Up to date the main pathological mechanisms of these diseases are not fully understood and consequently there is no complete treatment option for those diseases. In this aspect stem cells have drawn attention of many researchers and health care professionals. Considering ethical issues, safety and facile isolation Mesenchymal … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 28 Nov 2014 · 6,768 accessesView PDFCite
Literature ReviewOpen accessIn the abstractRemineralization Potential of Bioactive Composite Resins: A Systematic ReviewLuiza Maria Schneider, Maria Ritha Veiga Colognese, Poliana Maria de Faveri Cardoso et al.To evaluate the clinical performance and potential of giomer-based materials in promoting the remineralization of dental structures through a systematic review of the literature. A comprehensive literature search was conducted using PubMed, Scopus, and Web of Science databases up to March 2024. “giomer,” “S-PRG,” “bioactive restorative materials,” “remineralization,” and “dental caries.” Inclusion criteria comprised clinical studies involving human subjects, with … …Current Research in Dentistry, Vol. 17, Issue 1 · 29 Jan 2026 · 3,143 accessesView PDFCite
Case ReportOpen accessIn the abstractAcyclovir May Be Used to Treat Certain Long COVID Patients Regardless of Herpesvirus Reactivation: Case ReportDenise Stewart, Martin Oswald SavageFundamental causes of long COVID or Post-Acute Sequelae of COVID-19 (PASC) are still under investigation while it remains a significant burden to millions of patients worldwide even after a relatively mild acute Coronavirus Disease 2019 (COVID-19) episode. Treatment and management programs are yet to be developed. The foremost hypotheses for underlying PASC pathophysiology include: The persistence of the virus in … …American Journal of Infectious Diseases, Vol. 20, Issue 1 · 12 Mar 2024 · 25,583 accessesView PDFCite