Research ArticleOpen accessPhrase in the titleChronological Age and Dental Age Using Demirjian in Down Syndrome ChildrenAzrra M. Nawawi, Meirina Gartika, Willyanti SoewondoDown syndrome is a chromosomal abnormality (trisomy 21) characterized by an extra chromosome 21. People with Down syndrome have impairement in mental and physical development, including delayed dental development. Dental age is stage of development of teeth measured by maturation stage of teeth. This study aims to determine or asses the growth or maturation of permanent teeth in children with … …American Journal of Applied Sciences, Vol. 15, Issue 3 · 7 Mar 2018 · 8,263 accessesView PDFCite
Research ArticleOpen accessIn the abstractEpigenetic Regulation of Extracellular Matrix Remodeling in Skin Aging: Mechanisms and InteractionsJiguang Yang, Yusong Shi, Xiaoqing YanSkin aging results from complex interactions between genetic factors, environmental stressors, and epigenetic modifications that regulate extracellular matrix (ECM) remodeling. Accumulation of senescent cells impairs tissue regeneration through mechanisms including telomere shortening, reactive oxygen species accumulation, and ultraviolet (UV) radiation exposure. While epigenetic pathways regulate skin homeostasis, regeneration, and senescence, the specific epigenetic changes occurring during UV exposure, chronological aging, … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 15 Feb 2026 · 1,458 accessesView PDFCite