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Research ArticleOpen accessIn the keywordsLumbricus rubellus Protein Fraction DLBS1033N Increases Nerve Growth Factor Expression via Tyrosine Kinase ActivationAgung Heru Karsono, Raymond Rubianto Tjandrawinata, Maggy Thenawidjaja SuhartonoNerve injury occurred due to mechanical, thermal, chemical, or ischemic factors. Nerve regeneration is needed for recovery. Schwann cell proliferation and differentiation are important factors in the nerve regeneration process. Schwann cells release neurotrophins in the nerve regeneration process. In this study, Lumbricus rubellus protein fraction DLBS1033N was used as therapeutic protein candidate for nerve regeneration treatments. DLBS1033N treatments promoted … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 1 · 7 Feb 2018 · 9,407 accessesView PDFCite
Research ArticleOpen accessIn the keywordsClinical Evidence of Autologous Graft versus Tumor EffectLuis F. PorrataProblem statement: The infused alloreactive lymphocytes in allogeneic stem cell transplantation (Allo-SCT) lead to an unspecific immune response causing Graft-Versus-Tumor (GVT) effect and Graft-Versus-Host Disease (GVHD). The current dogma regarding the anti-tumor effect of GVT is only observed in the Allo-SCT and not in the autologous hematopoietic stem cell transplantation (AHSCT). Approach: This article reviewed the medical literature to show … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Jan 2009 · 7,506 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRedox Sensing and Cardiac Myocyte Loss: Some Recent InsightsShyamal K. GoswamiGeneration of reactive oxygen-nitrogen species (ROS/RNS) has long been ascribed to pathophysiological conditions like ageing, neurodegenerative and cardiovascular disorders. However, more recent evidences suggest that while generation of ROS/RNS at a higher threshold is deleterious, at a lower dose these can act as second messengers, influencing specific cellular events like cell growth and differentiation, embryonic development, protection against ischemic injuries … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,349 accessesView PDFCite
Research ArticleOpen accessIn the abstractHematologic Cancer Cell Detection and Classification Using Optimized VGG-19 with Stratified K-fold Cross-ValidationHema Patel, Himal Shah, Gayatri Patel, Atul PatelThe most prevalent pediatric blood malignancy is acute lymphoblastic leukemia (ALL). ALL is a lethal disease in which patients have a lower survival rate. Its prompt detection and precise categorization are essential for successful treatment. Manual microscopic diagnosis is laborious, prone to mistakes, and heavily reliant on specialized knowledge. With stratified 7-fold cross-validation, which assures an equal ratio of normal … …Journal of Computer Science, Vol. 21, Issue 11 · 24 Dec 2025 · 1,812 accessesView PDFCite
Research ArticleOpen accessIn the abstractEnhanced Immunity of Hybrid Grouper (Epinephelus sp.) Against Viral Nervous Necrosis Using a Recombinant Protein Nanovaccine from Chlorella VulgarisUun Yanuhar, Herly Evanuarini, Heru Suryanto et al.Hybrid Grouper (Epinephelus sp.) is an important export commodity in marine aquaculture, yet Viral Nervous Necrosis (VNN) remains a major threat. Nanovaccines are a type of vaccine developed by combining vaccine ingredients with silver nanoparticles and recombinant protein from Chlorella vulgaris. These formulations are designed to effectively boost the body's immune system response to prevent disease infection and destroy pathogenic … …OnLine Journal of Biological Sciences, Vol. 25, Issue 3 · 22 Nov 2025 · 2,154 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Research ArticleOpen accessIn the abstractRadiation Triggered Phenotypic Changes of Regulatory T CellsLantao Liu, Yan Peng, Deqin Zhang, Dongsheng NiuIonizing radiation disrupts the immune balance easily. Regulatory T (Treg) cells directly affect the immune balance after radiation exposure. Meanwhile, the present study is to investigate the survival ability and phenotypic changes of Treg cells induced by 60Co γ-rays in order to expand the understanding on how Treg cells modulated by radiation. Mice lymphocytes were isolated from thymus and spleen … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 1 · 20 Mar 2022 · 5,828 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunological Response of Albino Rats Immunized with UV-Killed Candida albicansAhmad Ibrahim, Yahaya Abdullahi Umar, Mohammed Shehu BusuThe treatments of systemic candidiasis in humans with the current antifungal drugs of choice such as azole derivatives and amphotericin B have raised issues of toxicity and resistance among others. The immunogenic property of killed C. albicans was explored to evoke immunological response in the possible prevention of candidemia. Rats were immunized after acclimatization on two occasions with 106 cells/ml … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 3 · 26 Jul 2019 · 7,714 accessesView PDFCite
Research ArticleOpen accessIn the abstractIsolation and Identification of Oral Cancer Stem Cells (CSC) within Commercially Available Cell LinesRobert Chauncey, Kai Hatch, Toni Jilka et al.Previous studies have demonstrated some tumors develop or maintain a small sub-population of cells with stem cell-like properties. This Cancer Stem Cells (CSC) may exhibit differential properties that allow their escape from traditional radiation or chemotherapy treatments and may therefore be responsible for cancer recurrence. Few studies have explored this phenomenon among oral cancer cell lines, therefore the objective of … …Current Research in Dentistry, Vol. 9, Issue 1 · 2 Jun 2018 · 12,719 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvolvement of the α/β Isoform of p38 MAP Kinase in Chemotactic Responses of Human Eosinophils to Eotaxin (CCL11) and RANTES (CCL5)Anwar M Hasan, Gordon DentEosinophils are the principal effector cells for allergic inflammation in a variety of diseases, in which they contribute to tissue damage and remodelling processes via the secretion of cytotoxic granular proteins and cytokines. The intracellular mechanisms that control the activation, recruitment and survival of eosinophils are fundamental in understanding these disease processes. Phosphoinositide 3-kinase (PI3K) has been shown previously to … …American Journal of Immunology, Vol. 13, Issue 4 · 26 Oct 2017 · 7,943 accessesView PDFCite