5 results for “Carcinogenicity”

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Research ArticleOpen accessIn the keywordsWater Characteristics Assessment, Bioaccumulation and Health Risk Evaluation of Possible Ingestion of Toxic and Essential Metals in Chromidotilapia guntheri Sourced from Ada River, West AfricaTunde Ohiokhioya Thaddeus Imoobe, Eugene Iragboghie Okhakhu, Osikemekha Anthony AnaniThe water ecosystem has been acclaimed to be polluted with various chemicals that may pose possible risks to the biota therein and affect the end consumers who ingest them via the food chain system. This study evaluates the water characteristics, bioaccumulation and non-carcinogenic risk potentials in the ingestion of toxic metals like (Cu, Fe, Zn, Mn and Pb) in Chromidotilapia … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 18 Mar 2024 · 4,772 accessesView PDF Cite

Research ArticleOpen accessIn the abstractConstitutive Androstane Receptor Dependent and Independent Modulation of CYP3A2, CYP1A2 by Phenobarbital and Fibrate in Rats’ LiverMohamed Mohamed Ahmed, Mustafa Shukry, Zein Shaban Ibrahim et al.Cytochrome P450 enzymes, CYP3A and CYP1A are major drug metabolizing enzymes in the liver. CYP3A enzymes have a major role in the metabolism of 30-40% of all used drugs. CYP1A2 is a key enzyme having an important role in the metabolic clearance of 5% of currently marketed drugs. CYP1A2 participates in the metabolic activation of chemical mutagens in cooked food, … …American Journal of Biochemistry and Biotechnology, Vol. 9, Issue 3 · 21 Sep 2013 · 7,381 accessesView PDF Cite

Research ArticleOpen accessIn the abstractQuercetin in Dimethyl Benzanthracene Induced Breast Cancer in RatsNatla Sashidhar Reddy, Parthasarathy Nirmala, Natesan Chidambaram, Pammi Ashok kumarProblem statement: Vincristine a commonly used anticancer agent in the treatment of breast cancer results in serious adverse effects like teratogenicity, neurotoxicity and carcinogenicity on long term use. Drug resistance is also a common problem encountered with vincristine. Hence the effect of flavonol quercetin, a known antioxidant with no known documented adverse effect was tried in treatment of DMBA induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 30 Jul 2012 · 8,138 accessesView PDF Cite

Research ArticleOpen accessIn the abstractDecolorization of Mordant Orange-1 by Marinobacter algicola MO-17R. S. Shertate, Prakash ThoratProblem statement: The textile industries use different types of dyes in their processing units which are liberated in natural marine water bodies. This release of dyes in turn affect the marine flora and fauna very adversely. Approach: The release of textile dyes into the environment is a matter of concern due to the toxicity, mutagenicity, carcinogenicity and xenobiotic nature. Hence, … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 25 Feb 2012 · 7,513 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Health Risk of Formaldehyde to Human BeingsS. Norliana, A. S. Abdulamir, F. Abu Bakar, A. B. SallehProblem statement: Formaldehyde was classified as a potential human carcinogen, identified by the US Environmental Protection Agency and International Agency for Research on Cancer as a Class 2A carcinogen. It also can cause irritation to human. However, formaldehyde present in biological fluids or tissues and environment as a result of natural processes or from man-made sources and can be emitted … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 15,273 accessesView PDF Cite