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7 results for “Carbon Tetrachloride”
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Research ArticleOpen accessPhrase in the titleAqueous Stem Bark Extract of Spathodea campanulata (P. Beauv) Modulates Carbon Tetrachloride Induced Hepatic Damage in RatsCharles Ansah, Phyllis Elsie Dadzeasah, Emmanuel AsiamahThe objective of the present study was to evaluate the hepatoprotective and curative potential of the aqueous extract of the stem bark of Spathodea Campanulata (SCE) in a carbon tetrachloride-induced model of hepatotoxicity in rats. Rats pre-treated with 625 mg kg-1, 1250, 2500 mg kg-1 or silymarin (50 mg kg-1) p.o for 3 days were intoxicated with CCl4 (1 mL … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 1 · 27 May 2013 · 8,999 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleHepatoprotective Impact Of TLR9 Antagonist ODN 2088 Against Carbon Tetrachloride (CCl4)-Induced Hepatic InjuryBadr AlzahraniThe main objective of this study is to evaluate the hepatoprotective impact of TLR9 antagonist ODN 2088 against carbon tetrachloride (CCl4)-induced acute liver injury. In this study, 24 mice were grouped into four groups. CCl4 was introduced in all groups except for the control group intraperitoneally after pretreatment with ODN 2088 and silymarin for seven days. To assess the liver … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 4 Jan 2020 · 7,659 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleHepatoprotective Effect of Opuntia Ficus-Indica Aqueous Extract against Carbon Tetrachloride-Induced Toxicity in RatsZouhir Djerrou, Zineb Maameri, Sihem Halmi et al.The present study was undertaken to evaluate the hepatoprotective activity of Opuntia ficus-indicaL. aqueous extract. About 24 Wistar male rats were divided randomly to 4 groups of 6 each. The 1st was given distilled water and served as normal control (CRL). The 2nd was intoxicated orally with carbon tetrachloride at a dose of 1.5 mL/kg each 72 h (CCl4 group) … …OnLine Journal of Biological Sciences, Vol. 15, Issue 2 · 2 Jun 2015 · 7,254 accessesView PDFCite
Research ArticleOpen accessIn the keywordsUltrastructural and Circadian Morphometric Characteristics of Rat Pinealocytes Under Physiological and Toxic ConditionsAnna I. Anurkina, David A. Areshidze, Maria A. Kozlova, Valery P. ChernikovCarbon tetrachloride (CCl₄) exhibits pronounced neurotoxic effects following acute or chronic exposure. Recent studies indicate that the pineal gland responds to CCl₄ intoxication by altering its secretory function, although detailed ultrastructural changes in pinealocytes remain inadequately investigated. This research addresses the urgent need to elucidate the mechanisms of CCl₄ toxicity on the pineal gland, which could contribute to developing strategies … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 1 Jun 2026 · 1,170 accessesView PDFCite
Research ArticleOpen accessIn the keywordsModulatory Effects of Bryophyllum Pinnatum Leaves Extract on Peroxidation Indices of CCl4 Induced-Hepatotoxicity in Wistar Albino RatsChioma Assumpta Anosike, Sophia Uyo Mokwunye, Victor Eshu Okpashi, Obiorah AbonyiThis research investigated the modulatory effect of methanol extract of Bryophyllum pinnatum leaves on peroxidation indices of CCl4-induced hepatotoxicity. Thirty rats of average weight 150g divided into six groups of 5 rats each were used for the study. Group one (control) received water and paraffin for ten days. Group two (treatment control) received water only, group 3 (standard control), received … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 3 · 17 Dec 2017 · 7,448 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Role of Ganoderma lucidum Polysaccharides Against Stress Induced by Heavy Metals in Caenorhabditis elegansHuixiu Ma, Dehui Dai, Guicai Chen, Weilian HuAli, H., Khan, E., & Ilahi, I. (2019). Environmental Chemistry and Ecotoxicology of Hazardous Heavy Metals: Environmental Persistence, Toxicity, and Bioaccumulation. Journal of Chemistry, 2019, 6730305. https://doi.org/10.1155/2019/6730305 Aljerf, L., & Aljerf, N. (2023). Food products quality and nutrition in relation to public. Balancing health and disease. Progress in Nutrition, 25(1), e2023024. https://doi.org/10.23751/pn.v25i1.13928 Aljerf, L., Williams, M., Ajong, A. B., Onydinma, … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 2 · 18 May 2024 · 6,947 accessesView PDFCite
Research ArticleOpen accessIn the abstractBilirubin Lowering Potential of Annona muricata (Linn.) In Temporary Jaundiced RatsFareed K.N. Arthur, Eric Woode, Ebenezer O. Terlabi, Christopher LarbieProblem statement: Annona muricata is used in Ghanaian traditional medicine for the treatment of jaundice. Work done has demonstrated A. muricata to be effective in treating carbon tetrachloride-and acetaminophen-induced hepatic damage, hepatic jaundice and toxicologically safe up to 1000 mg kg-1 in animals. Current study evaluated the bilirubin-lowering potential of A. muricata aqueous extract in phenylhydrazine-(40 mg kg-1) induced jaundice … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 23 May 2012 · 12,772 accessesView PDFCite