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26 articles for “Anticancer activity”
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Research ArticleOpen accessPhrase in the titleBioactive Compounds from Sponge Associated Bacteria: Anticancer Activity and NRPS-PKS Gene Expression in Different Carbon SourcesJepri Agung Priyanto, Rika Indri Astuti, Jun Nomura, Aris Tri WahyudiSponge associated bacteria with diverse NRPS-PKS genes could be the alternative source of bioactive compounds. This study aimed to analyze the activity as well as the regulatory mechanism regarding the anticancer properties derived from these bacteria against cancer cell lines. Extraction of bacterial metabolites using ethyl acetate solvent resulted yield ranging from 0.003 to 0.016% (w/v). Six extracts of bacterial … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 5 Oct 2017 · 8,886 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAnticancer Activity of Isolated Chemical Constituents from Miliusa smithiaeChonthicha Naphong, Wilart Pompimon, Punchavee SombutsiriMiliusa plants belonging to the family Annonaceae are found in Thailand and have been used as Thai traditional medicines. There have been a few previously reports on the chemical constituents of plants in this genus, describing the presence of aporphine alkaloids, terpenoids, flavonoids, phenylpropanoids, styrylpyrones, bis-styryls and homogentisic acid derivatives. Miliusa smithiae, a new species for Thailand and world, has … …American Journal of Applied Sciences, Vol. 10, Issue 8 · 24 Jul 2013 · 7,259 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAnticancer Activity of Some New Synthesized Tetrahydroquinoline and Tetrahydrochromene Carbonitrile DerivativesUsama W. Hawas, Mohamed A. Al-Omar, Abd El-Galil E. Amr, Abu El-Ftouh G. HammamProblem statement: In continuation to our search for new heterocyclic chemistry based anticancer, the suggestion, synthesis, structure elucidation of some naphthalene, chromene and quinoline derivatives 3-7 were realized herein using 3-methylcyclohexanone 1 as a starting material. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, … …American Journal of Applied Sciences, Vol. 8, Issue 10 · 14 Sep 2011 · 7,484 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleIn Vitro and In Vivo Anticancer Activity of Bacoside A from Whole Plant of Bacopa Monnieiri (Linn)N. S. Prakash, R. Sundaram, S. K. MitraProblem statement: Natural products have long been a fertile source of cure for cancer, which is projected to become the major cause of death in this century. Major classes of anticancer compounds include alkaloids, terpenoids, flavonoids and lignans. We have chosen terpenoids (bacosides) because terpenoids like taxol are currently being used in cancer chemotherapy. The anticancer activity of Bacoside A … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 1 · 7 Jun 2011 · 9,663 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAnticancer Activities of Some New Synthesized Thiazolo[3,2-a]Pyrido[4,3-d]Pyrimidine DerivativesAshraf M. Mohamed, Abdel-Galil E. Amr, Musaed A. Alsharari et al.Problem statement: This study describes the synthesis and anticancer activities of a new series of thiazolo[3,2-a]pyrimidines derivatives (2-7) using 3,5-bisarylmethylene-1-methyl-4- piperidone and 4-aryl-8-arylmethelene-6-methylpyrido[4,3-d]pyrimidine-2(1H)thiones as a starting materials. Approach: The antitumor activities of the newly synthesized compounds 4-7 were evaluated utilizing 60 different human tumor cell lines, representing leukemia, melanoma, lung, colon, brain, ovary, breast and prostate as well as kidney. … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 2 · 23 Aug 2011 · 10,087 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Effect of Phyllanthus taxodiifolius Beille Extracts and its Triterpenoids Studying on Cellular Energetic Stage of Cancer CellsPatiwat Sakkrom, Wilart Pompimon, Puttinan Meepowpan et al.Problem statement: The Multidrug Resistance phenomenon (MDR) is the cause of unsuccessful in cancer chemotherapy. The tradition plant is the population used as the alternative medicine in cancer therapy. Due to, P. taxodiifolius is medicinal Thai plant which is used as diuretic drug which has never been explored as the anticancer activities. Approach: Air-dried powder of P. taxodiifolius leaves and … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 8,750 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntiproliferative Potential of Pomegranate Peel Extract in MDA-MB Breast Cancer Cell LinesManal Asif Hamdulay, Fatema Yusuf Singaporewala, Grisilda Vidya Bernhardt et al.Nutraceuticals have gained recognition as adjuvant therapies in cancer treatment due to their non-toxic and protective properties. Among various natural products, pomegranate peel with high antioxidant capacity and rich polyphenol content suggest potential anticancer properties. Previous studies have shown promising anticancer effects of other parts of the pomegranate. The purpose of this research is to compare the effectiveness of Pomegranate … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 1 · 13 May 2025 · 5,582 accessesView PDFCite
Review ArticleOpen accessIn the abstractBioprospection of Endophytic Bacteria Isolated from Mangrove Ecosystems and their Potential Biotechnological ApplicationsAlfian Mubaraq, Mariani Sembiring et al.The unique mangrove ecosystem hosts a variety of microorganism activities, including the crucial role of endophytic bacteria. Microorganisms found in mangrove forests play an important role in maintaining the biosphere by uniting various living beings and can be vital for future biotechnological applications. The use of microorganisms in the field of biotechnology is prevalent for producing antimicrobials against pathogenic bacteria … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 16 Aug 2024 · 4,996 accessesView PDFCite
Research ArticleOpen accessIn the abstractIsolation and Characterization of Chemical Constituents, Cytotoxicity, Antibacterial and Antioxidant Activity of the Compounds from Leptadenia hastata Roots Extract ByIsaac John Umaru, Hauwa A. UmaruThe aim of this work was to extract, isolate and characterise the chemical constituent from Leptadenia hastata roots. Fresh roots were washed and dried and was subjected to sequential maceration in polar and non-polar solvents. And introduced into rotary evaporator to concentrate the extract. Isolated compound was subjected to Thin Layer Chromatography and spectral analysis such as column and UV-Visible … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 4 · 24 Dec 2019 · 7,959 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis, Ant Proliferative Activity and Docking Study of New Quercetin Derivatives against MDA-MB231 Breast Cancer Cell LinesReham Adnan Al-Anssari, Rita S. Elias, Shaker A.N. AljadaanMDA-MB231 is a very aggressive and invasive triple negative breast cancer, which present with limited treatment options. Unlike other breast cancer types, it is characterized by absence of hormonal receptors of estrogen, progesterone as well as human epidermal growth factor receptor 2, rendering it unsuitable for hormonal therapy and a perfect candidate for chemotherapy. Quercetin is a common natural flavonoid … …American Journal of Applied Sciences, Vol. 16, Issue 5 · 26 Jun 2019 · 8,790 accessesView PDFCite