28 results for “Anti-Oxidative”

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Research ArticleOpen accessIn the keywordsScreening Neuropharmacological Activities of Kaempferia parviflora (Krachai Dam) in Healthy Adult Male RatsThaneeya Hawiset, Supaporn Muchimapura, Jintanaporn Wattanathorn, Bungorn SripanidkulchaiProblem statement: Although the global prevalence of psychological disorders is increasing continually, the efficacies of therapeutic strategies are still very limited. Oxidative stress has been implicated in the pathogenesis of psychiatric disorders and substance possessing antioxidant activity can alleviate the mentioned conditions. Therefore, we hypothesized that Kaempferia parviflora, a medicinal plant claimed for nerve tonic, also possessed the neuropharmacological activities … …American Journal of Applied Sciences, Vol. 8, Issue 7 · 24 Jun 2011 · 8,697 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsPurification, Structural Characterization and Anti-Aging and Stress Activities of Cordyceps Mycelium Polysaccharides from Paecilomyces HepialiXiaokang Hu, Huixiu Ma, Guicai Chen et al.This study identified and characterized the bioactive polysaccharide components from Cordyceps mycelium powder (CMP) derived from Paecilomyces hepiali, evaluating their anti-aging and stress-protective activities. Initial screening using Drosophila melanogaster revealed that crude Cordyceps polysaccharides (CCP) exhibited comparable effects to CMP and Cordyceps aqueous extracts (CAE) on natural lifespan and UV stress resistance, suggesting CCP as the primary bioactive component. CCP … …American Journal of Biochemistry and Biotechnology, Vol. 21, Issue 4 · 16 Feb 2026 · 1,698 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsPossible Mechanism of Plumbago zeylanica in Prevention of Hepatic Dammage in Wistar RatRohit Goyal, Pyare Lal SharmaPlumbago zeylanica root has been used traditionally to treat various body ailments including liver diseases. The present study was designed to investigate the hepatoprotective effects of standardized methanolic extract of Plumbago zeylanica root on paracetamol, CCl4 and alcohol induced hepatic injuries in rats and its possible mechanism(s) of hepatoprotection. Administration of hepatotoxicants like paracetamol (3 g kg-1, p.o.) or CCl4 … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,638 accessesView PDF Cite

Research ArticleOpen accessIn the keywordsUncommon Toxicologic Profile at Toxic Doses of CPI-613 (an Agent Selectively Alters Tumor Energy Metabolism) in Rats and Minipigs Reflects Novel MechanismClaudia Maturo, King C. Lee, Robert Rodriguez, Robert ShorrProblem statement: CPI-613 is a novel anticancer agent and the toxicological profile has not been assessed. Accordingly, the objective of these studies was to thoroughly evaluate the Toxicokinetic (TK) effects of CPI-613 in rats and to compare the toxicological profile of rats to minipigs to determine if there were differences between the two animal species. Approach: These studies involved assessments … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 4 · 13 Jun 2011 · 9,582 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAluminium-Induced Hepatotoxicity and the Protective Role of Withania somnifera (Ashwagandha) in Wistar RatsAnchana Babu, Rekha D Kini, Nayanatara Arun Kumar, Megha GokulAluminium is a widely distributed environmental contaminant whose chronic exposure leads to accumulation in multiple organs, including the liver, resulting in oxidative stress and tissue damage. When reactive oxygen species production exceeds the body's antioxidant defense capacity, cellular injury ensues — a mechanism central to aluminium-induced hepatotoxicity. Withania somnifera (Ashwagandha), an evergreen herb of the Solanaceae family widely cultivated in … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 6 Apr 2026 · 1,449 accessesView PDF Cite

Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDF Cite

Research ArticleOpen accessIn the abstractInhibitory Effect of Crude Walnut Leaf Polysaccharides on Oxidative Damage of Proteins and Proliferation of SGC-7901 CellsShuqing Yang, Zhike Xie, Shuyan Yu et al.In this paper, we studied the inhibitory effect of crude Walnut Leaf Polysaccharides (WLP) on free radical-induced oxidative damage of proteins and anti-proliferation activity on human Gastric Cancer cells (SGC-7901). The oxidative degradation of Bovine Serum Albumin (BSA), mouse brain proteins (MBP) and Mouse Liver Proteins (MLP) induced by hydroxyl radical and alcoxyl radical was analyzed by Sodium Dodecyl Sulfate-Polyacrylamide … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 26 Apr 2020 · 7,057 accessesView PDF Cite

Research ArticleOpen accessIn the abstractModulation of Aging in Yeast Saccharomyces cerevisiae by Roselle Petal Extract (Hibiscus sabdariffa L.)Sarima, Rika Indri Astuti, Anja MeryandiniCellular aging drives diseases. Free radicals are called the main cause of cellular aging. Antioxidants can protect the body from free radical attack by reducing its negative effects. An antioxidant source can be obtained from plants, such as roselle (Hibiscus sabdariffa. L). This research was conducted to analyze the ability of roselle petals extract to increase the life span of … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 1 · 6 Apr 2019 · 9,646 accessesView PDF Cite

Research ArticleOpen accessIn the abstractImpact of Ultra Violet Radiation on Polyethylene Packaged Water Exposed at Varying Conditions: Are we Drinking Micro-Plastics?James Matthew Anayo, Victor Eshu Okpashi, Ikechukwu N.E. OnwurahThe public is worried about how their health is impacted by microplastics in sachet water. This awareness has repercussion for water producing factories and public health organization in managing health hazard associated with microplastic ingestion. Many countries in Africa, with concern to Nigeria, the act of packaging water in polyethylene materials by water producing factories has become accustomed. These packaged … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 1 · 29 Jan 2018 · 9,915 accessesView PDF Cite

Research ArticleOpen accessIn the abstractFactors Those Up Regulate Klotho and Glutathione Peroxidase-1 Gene Expression Improve Renal Function in Rats with Acute Renal FailureFatma E. El-Gendey, Shabaan A. Hemeda, Gamal A. Sosa, Naglaa F. AlhusseiniAcute Renal Failure (ARF) has traditionally been defined as the abrupt and progressive loss of kidney functions resulting in the retention of urea and other nitrogenous waste products associated with interstitial inflammation, tubular injury and increasing Tumor Necrosis Factor (TNF). Mortality in patients with ARF remains high >50% in severely ill patients. Klotho gene is a new anti-aging gene. Genetic … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 3 · 15 Aug 2015 · 7,097 accessesView PDF Cite