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11 results for “Angiotensin II”
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Research ArticleOpen accessEvery word in the titleRole of Angiotensin-Converting Enzyme and Vitamin D Receptor Gene Polymorphisms in Cancer Anorexia-Cachexia SyndromeAriele Fabris, Paolo Biagioni, Tiziana Punzi et al.The ubiquitin-proteasome pathway is a crucial connection between aberrant immune system activation, systemic inflammation and Cancer Anorexia-Cachexia Syndrome (CACS), a syndrome that culminates in hyper-activation of the ubiquitin-proteasome pathway. Angiotensin directly up-regulates this pathway, while vitamin D down-regulates it indirectly through the insulin-like growth factor-1 pathway. We investigated the genetic predisposition towards CACS in a cancer population, examining Insertion/Deletion (I/D) … …American Journal of Immunology, Vol. 8, Issue 3 · 2 Aug 2012 · 9,560 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAT1-IR-beta Association: A New Mechanism for the Inhibition of Insulin Receptor Function in Breast CancerLakshmi Pulakat, Ravindra Kolhe, Nara GaviniEpidemiological evidence show that increased mortality in breast cancer is linked to hypertension and insulin resistance. Because Angiotensin II (Ang II), a hormone implicated in hypertension and insulin resistance, is a normal mitogen for breast tissue and elevated expression of the Ang II receptor AT1 is seen in breast cancer, we analyzed the effects of Ang II exposure on the … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 1 · 31 Mar 2008 · 7,016 accessesView PDFCite
Research ArticleOpen accessIn the keywordsRenal Actions of Neutral Endopeptidase Inhibition in Rats with Chronic Heart FailureAmr M. Abbas, Ayman Z. Elsamanoudy, Adel ZalataProblem statement: We aim to evaluate the effects of acute and chronic inhibition of Neutral EndoPeptidase (NEP), by ONO-9902, on plasma and renal NEP gene expression, hemodynamic and renal parameters in rats with Chronic Heart Failure (CHF) following left Coronary Artery Ligation (CAL). Approach: Forty eight male Sprague-Dawley rats (220-240 g) were divided into sham and CAL groups. Myocardial infarction … …American Journal of Applied Sciences, Vol. 7, Issue 11 · 8 Nov 2010 · 7,087 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCardiovascular Effect of Capparis spinosa Aqueous Extract. Part III: Antihypertensive Effect in Spontaneously Hypertensive RatsZeggwagh Naoufel Ali, Mohamed Eddouks, Jean Baptiste Michel et al.This study aims to evaluate the hypotensive activity of Capparis spinosa aqueous extract (CSAE) in spontaneously hypertensive (SH) rats. CSAE was lyophilised and administrated daily at a dose of 150 mg kg-1 for 20 days. CSAE administration produced a significant reduction in systolic blood pressure after eight days of oral administration (p 0.05) after 20 days of oral administration. We … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 3 · 30 Sep 2007 · 9,327 accessesView PDFCite
Research ArticleOpen accessIn the abstractUnveiling the Potential of Dombeya buettneri K.Schum As a Drug Agent: Molecular Docking of Compounds With Enzymes Linked to Diabetes and Neurodegenerative DiseaseEsther Emem Nwanna, Samuel Chima Ugbaja et al.This study investigated the mechanisms of Dombeya buettneri (snowball leafy) extracts on diabetes, hypertension, and neurodegenerative diseases. It compared extracts obtained using steep water (a by-product of corn wet milling) and aqueous water. The extracts were analyzed for total phenol, total flavonoid content, antioxidant activities such as FRAP, ABTS, NO, DPPH, iron-induced lipid peroxidation assay, degradation of deoxyribose (Fenton’s reaction), … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 1 Feb 2026 · 2,025 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of the Renoprotective Effects of Valsartan in Methotrexate-Induced Acute Kidney Injury in RatsDina KutbiMethotrexate (MTX) is a widely used chemotherapeutic agent known for its nephrotoxic effects, which can lead to acute kidney injury in hospitalized patients. However, the mechanism by which MTX induces nephrotoxicity is not entirely clear, but it is believed to involve oxidative stress and direct toxic effects on renal tubules. Valsartan, an angiotensin II receptor blocker, has been shown to … …OnLine Journal of Biological Sciences, Vol. 24, Issue 3 · 4 May 2024 · 4,571 accessesView PDFCite
Review ArticleOpen accessIn the abstractSARS-CoV-2-Induced Damage on the Cardiovascular System: Molecular MechanismsMel·lina Pinsach-Abuin, Ramon Brugada TerradellasSince its emergence in late December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) - the causative agent of coronavirus disease 2019 (COVID-19) - has spread rapidly world-wide, becoming a global pandemic in March 2020 that is still active. In addition to the severe pulmonary damage, clinical studies have reported that COVID-19 is associated with the development of cardiovascular … …American Journal of Infectious Diseases, Vol. 17, Issue 4 · 25 Nov 2021 · 6,791 accessesView PDFCite
Case ReportOpen accessIn the abstractThe Diagnostic and Etiologic Challenge of Myocarditis in Oncologic Patients: Acute Myocarditis During Induction Treatment with All-Trans Retinoic AcidNúria Coma, Sergio Moral, Rosa Coll et al.Myocarditis is an inflammatory disease of the myocardium characterized by myocardial infiltration with inflammatory cells and non-ischemic myocytic necrosis. Its diagnosis is based on clinical, electrocardiogram, laboratory and echocardiographic parameters and also cardiac magnetic resonance or endomyocardial biopsy when possible. It occurs primarily as a result of infections that include viruses, parasites, bacteria and fungi. Moreover, there are other causes … …American Journal of Infectious Diseases, Vol. 17, Issue 3 · 7 Jun 2021 · 7,013 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrescription Pattern of Anti-Hypertensive Drugs in Adherence to JNC- 7 GuidelinesKrishna Murti, M. Arif Khan, Akalanka Dey et al.The main objective of the present study to investigate the utilization pattern of antihypertensive drugs in hypertensive patients and to find out whether the prescription pattern is in adherence with the JNC7 guidelines for the management of hypertension. A prospective study was conducted and drug utilization data were collected from 137 hypertensive patients who were attended as Out Patient Department … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 2 Jun 2015 · 8,273 accessesView PDFCite
Research ArticleOpen accessIn the abstractRISK-BENEFIT ANALYSIS AND RISK MINIMIZATION OF QUINAPRIL: A REVIEWAnjo Sunny, M. Arif Khan, Darpelly Mahesh et al.The purpose of this review is to give the readers an insight about the risks and benefits of ’quinapril’, a potent Angiotensin Converting Enzyme Inhibitor (ACEI). Quinapril is a highly effective novel drug indicated for treatment of congestive heart failure and hypertension. Despite of the fact that safety profile is quite well with low incidence of adverse effects, an attempt … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 12 Feb 2014 · 7,254 accessesView PDFCite