63 results for “Allele”

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Research ArticleOpen accessEvery word in the titleDistribution of Alleles and Genotypes of ACE2 Gene Polymorphisms (rs2285666 and rs35803318) and Association with COVID-19 Among Populations in KazakhstanAnar Bisseneva, Konstantin Li, Gayane Pogossyan, Valeriya ProtasThere is still no definitive confirmation regarding the association between ACE2 gene polymorphisms and COVID-19. This study was conducted to analyze the distribution of alleles and genotypes of the ACE2 gene rs2285666 and rs35803318 two polymorphisms and their possible association with COVID-19 among two ethnic groups, namely, the Kazakhs and Eastern Slavs, residing within the same geographic area in the … …OnLine Journal of Biological Sciences, Vol. 24, Issue 1 · 31 Oct 2023 · 4,942 accessesView PDF Cite

Research ArticleOpen accessEvery word in the titleThe Association of HLA Class II Alleles with the Response to Alfa-Interferon/Ribavirin Therapy in Chronic Hepatitis C PatientsAwny Aly Abol-Ez Gawish, Nahla Abd El-Hamid Mohammed, Rasha Adel Sayed Ahmed Hussein, Elsaid Galal El-BadrawyHuman Leucocyte Antigens (HLA) class II appears to play an important role in the individual’s immune response to viral infection. The present study was aimed at assessment of the relationship between HLA DRB1 alleles and the response to HCV combined therapy in Chronic Hepatitis C patients (CHC). We enrolled a total of 44 chronically infected HCV patients without Hepatitis B … …American Journal of Immunology, Vol. 11, Issue 3 · 12 Nov 2015 · 6,700 accessesView PDF Cite

InvestigationOpen accessIn the keywordsGenetic Structure of Populations of Kazakh Whiteheaded and Hereford Cattles on the Basis of Microsatellite DNAAdas Tileubekovna Tyngoziyeva, Talgat Nikolaevich Karymsakov, Serik Doldashevich NurbaevThis work is aimed at determination of genetic dissimilarities between two allied cattle breeds: Kazakh Whiteheaded and Hereford. Hair follicles were analyzed, from which DNA was extracted with subsequent amplification. Identification of amplification products was performed using an ABI Prism 310 genetic analyzer. Allele 147 was detected in Kazakh Whiteheaded cattle in locus BM 2113, there was no such allele … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 6 Dec 2017 · 7,427 accessesView PDF Cite

Research ArticleOpen accessIn the abstractAnalysis of Plasma Amyloid-Beta and Apolipoprotein E Genotypes as Markers of Alzheimer’s Disease in Healthy Korean AdultsEun Ju Oh, Jung Jae Lee, Bo Kyeung Jung, Jae Kyung KimThe presence of the ApoE4 allele interferes with human Amyloid-Beta (Aβ) clearance and reduces the neuronal damage response, which, in turn, is associated with increased Alzheimer’s Disease (AD) risk. Identifying individuals with the highest genetic risk may aid clinical AD diagnosis and prognosis. However, to the best of our knowledge, no previous study has performed blood-based analysis of ApoE polymorphisms … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 1 · 26 Mar 2024 · 4,492 accessesView PDF Cite

Research ArticleOpen accessIn the abstractFrequencies of the C1236T, G2677T/A, and C3435T Polymorphisms of the MDR1 Gene and their Haplotypes in UzbekistanS. B. Nurmatova, A. A. Abdurakhimov, O. S. Charishnikova et al.P-glycoprotein (P-gp) is encoded by the MDR1 gene and is involved in the pharmacokinetics of drugs. The best-known MDR1 gene polymorphisms are 1236C>T, 3435C>T, and 2677G>T/A, which are associated with protein folding, changes in mRNA levels, and drug pharmacokinetics. The aim of this study was to identify the frequency of distribution of functional polymorphisms C1236T, C3435T, G2677T/A of the MDR1 … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,022 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEstimating the Genetic Polymorphisms of Gujarat Population using 17 Y Chromosomal STR lociAditi Mishra, Ulhas Gondhali, Sumit ChoudharyThe present study aims to report genetic variations in unrelated male (n = 118) of the Gujarat population with the help of seventeen Y-STR markers (DYS456, DYS389I, DYS390, DYS389II, DYS458, DYS19, DYS385a/b, DYS393, DYS391, DYS439, DYS635, DYS392, Y GATA H4, DYS437, DYS438 and DYS448). Allele frequencies and forensic parameters were calculated. A total of 96 distinct alleles were reported with … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 23 Jun 2021 · 6,504 accessesView PDF Cite

Research ArticleOpen accessIn the abstractGenetics Polymorphisms of INHA in Local Goat Populations in South-West Sulawesi Region of IndonesiaMuhammad Ihsan Andi Dagong, Sri Rachma Aprilita Bugiwati, Lellah Rahim, Nurul PurnomoInhibin subunit alpha (INHA) is one important gene that control reproductive characteristics of animal. The aim of this research was to identify the genetic diversity of INHA gene of Kacang and Peranakan Etawa (PE) goat as local goat breed which were maintained by farmers at goat development centers in Sulawesi region, Indonesia. DNA samples were collected from 137 heads Kacang … …American Journal of Animal and Veterinary Sciences, Vol. 15, Issue 1 · 12 Mar 2020 · 7,273 accessesView PDF Cite

Research ArticleOpen accessIn the abstractGenotype Screening of Bovine Brachyspina in Taiwan Holstein CowsChun Hsuan Chao, Yi Ming Chen, Kuo Hua LeeThis study analyzed carrier frequencies of the genetic defect bovine brachyspina (BS) in the Holstein cows in Taiwan. In total, 1688 cows from 31 herds were included in the analysis, performed using the Igenity-Prime 50K single-nucleotide polymorphism chip. Of the 1688 cows, 68 (5.09%) were BS carriers (BY), a frequency lower than that reported in Taiwan previously. In Taiwan, the … …American Journal of Animal and Veterinary Sciences, Vol. 15, Issue 3 · 14 Aug 2020 · 6,971 accessesView PDF Cite

Research ArticleOpen accessIn the abstractKnock Down of Erythrulose Kinase (eyk1) Leads to the Enhancement of Erythritol Production in Yarrowia lipolytica Mutant Strain YE4-2Xinhe Zhao, Tianlong Huang, Yaxin Zhang et al.Erythritol is a nearly zero-calorie sweetener, which is in great demand in food and health care industry. Our previous work obtained a Yarrowia lipolytica mutant strain YE4-2 with high erythritol yield. However, its conversion rate of glucose needs further improvement. Erythrulose kinase (eyk1) participates in the early stages of erythritol catabolism; the existence of eyk1 prevents the accumulation of erythritol. … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 3 · 24 Jul 2020 · 6,750 accessesView PDF Cite

Research ArticleOpen accessIn the abstractSSR Analysis of Nuclear DNA of Annual and Perennial Sunflower Species (Helianthus L.)N.V. Markin, A.V. Usatov, A.V. Grinko et al.Genotyping of 29 species of genus Helianthus L., including 5 annual and 24 perennial species from the collection of the N. I. Vavilov All-Russian Institute of Plant Genetic Resources has occurred, for this purpose were selected 52 SSR markers, with localization on all the 17 linkage groups of the sunflower genome. All the studied sunflower samples had unique SSR loci … …OnLine Journal of Biological Sciences, Vol. 20, Issue 2 · 25 Apr 2020 · 6,895 accessesView PDF Cite