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33 articles for “Acute toxicity”
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Research ArticleOpen accessPhrase in the titleIN VIVO ANTIPLASMODIAL ACTIVITY AND ACUTE TOXICITY OF STANDARDIZED EXTRACT OF EURYCOMA LONGIFOLIA JACK. ROOT TRADITIONALLY USED TO TREAT MALARIAEti Nurwening Sholikhah, Mahardika Agus Wijayanti, MustofaA series of studies has been conducted to prove the Eurycoma longifolia Jack. root as an antimalarial. However, the in vivo antiplasmodial activity of E. longifolia Jack. root standardized extract and its lethal dose 50% (LD50) values is unknown. In vivo antiplasmodial activity was conducted on Plasmodium berghei infected Swiss mice as malaria model with 4-day suppression methods. Sixty mice … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 1 · 27 Dec 2013 · 7,732 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEvaluation of Antimalaria Activity and Acute Toxicity of Xetospongia spSyamsudin Abdillah, Rahmatul Wahida Ahmad, Yatnita Parama Cita, Noriah Mohd NoorWe investigated the in vivo activity of extract of Xetospongia sp against Plasmodium berghei Strain ANKA and acute toxicity in mice. The ethanolic extracts of the Xetospongia sp (50-400 mg kg-1 day) were screened for blood schizonticidal against P. berghei strain ANKA in mice during early and established infections. Acute toxicity of extracts of Xetospongia sp at the dose 5000 … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 2 · 2 Sep 2013 · 7,796 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleACUTE TOXICITY STUDY OF TOMATO POMACE EXTRACT IN RODENTSupaporn Muchimapura, Terdthai Tong-Un, Jintanaporn Wattanathorn et al.Tomato and tomato products are considered to be healthy food for the human diet. Although tomatoes have been widely studied for their phenolic content, less emphasize has been laid on toxicological effect of this plant. Thus, the purpose of the present study is to determine the acute toxicity effect of Lycopersicon esculentum, or commonly known as tomato, was administered orally … …OnLine Journal of Biological Sciences, Vol. 13, Issue 1 · 24 Feb 2013 · 7,683 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleAcute and Sub-acute Toxicity of Crataegus Aronia Syn. Azarolus (L.) Whole Plant Aqueous Extract in Wistar RatsAbdullah S. ShatoorProblem statement: Hawthorn comprises more than 200 species worldwide but very few species have been used medicinally. In Mediterranean region, the predominant species of the genus Crataegus is C. aronia syn. Azarolus (L). The extracts or tinctures prepared from the leaves, flowers and/or a fruit has been used traditionally for the treatment of different diseases including different cardiovascular problems. This … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 2 · 17 Aug 2011 · 14,660 accessesView PDFCite
Research ArticleOpen accessPhrase in the titleEvaluation of Acute Toxicity and Neuropharmacological Activities of PM-52Wipawee Thukhum-Mee, Jintanaporn Wattanathorn, Supaporn MuchimapuraThe neuropsychological disorders are increasing their importance nowadays. Unfortunately, the therapeutic efficacy is still not in satisfaction level. Therefore, the novel agents that are effective, safe, cheap and easy to approach are in required. Therefore, we aimed to determine the neuropharmacological activities of PM52, the novel herbal supplement. We had developed the PM52, a novel product comprising of Cissampelas pariera … …American Journal of Agricultural and Biological Sciences, Vol. 8, Issue 2 · 27 May 2013 · 7,351 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,241 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAcute and Subchronic Toxicity of Mulberry FruitsJintanaporn Wattanathorn, Wipawee Thukummee, Cholathip Thipkaew et al.At present, the application of phytomedicine worldwide is substantial increase. The data of the acute and subchronic toxicity studies on medicinal plants or fruits and vegetables used for medicinal purposes should be obtained in order to increase the confidence in its safety to human, particularly for the application as functional food. Despite the widely consumption of mulberry (Morus alba L, … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 19 Sep 2012 · 33,868 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe interplay between Cadmium and Zinc Induced Developmental Perturbations and Apoptosis in Daphnia MagnaNaima Hamid, Siti Nur Airina Binti Ibrahim et al.Assessing combined toxicity provides a realistic and comprehensive approach to determining toxicological effects in aquatic species under environmentally relevant conditions. This study was conducted to understand the effects of single and combined metal mixtures on freshwater flea and Daphnia magna. Environmentally Relevant Concentrations (ERCs) of Cadmium (Cd) and Zinc (Zn) at a low dose (10μg/L) and high dose (30 μg/L) … …American Journal of Environmental Sciences, Vol. 21, Issue 1 · 11 Jun 2025 · 6,015 accessesView PDFCite
Research ArticleOpen accessIn the keywordsToxicological Evaluation of Murraya Paniculata (L.) Leaves Extract on RodentsR. K. Goel, C. V. Rao, A. Singh, M. K. GautamProblem statement: Present study was aimed to explore the acute and sub-acute toxicities studies with orally administered 50% ethanolic leaves extract of Murraya paniculata. Approach: Acute toxicity (oral single dose, 50-2000 mg kg-1) includes any mortality and CNS and ANS toxicities in mice while, sub-acute toxicity (100, 200 and 400 mg kg-1, orally and once daily for 28 days) includes … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 9 Jul 2012 · 8,076 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAntidepressant-Like Activity of Banana Peel Extract in MiceTan Pei Tee, Halijah HassanProblem statement: Depressed mood, loss of interest or pleasure, feeling guilty, low selfesteem, sleep disturbance, loss of appetite, low energy and poor concentration are the characteristics of depression. This common mental disorder can occur in anyone regardless of genders, ages and backgrounds. People counteract it with psychotherapy and medications. Alternatively, some patients use herbal remedies as treatments. Recently, natural herbal … …Current Research in Medicine, Vol. 2, Issue 2 · 1 Oct 2011 · 18,671 accessesView PDFCite