77 results for “toxic effects”

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Research ArticleOpen accessIn the abstractSorbitol-Induced Diabetic-Like Retinal Lesions in Rats: Microscopic StudyGaber A. RamadanThe present study investigated the sorbitol toxicity on the retinas of normal albino rats and founded by the light microscope that intra-peritoneal injection of Sorbitol (10-mg/kg-body weight per day) for 24 weeks produced similar diabetic like retinal lesions in these rats. The retinopathic effects of sorbitol injection affect retinal microvessels, pigment epithelium, neural retina and glial cells. Cytoplasmic vacuolation of … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,634 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPharmacological Screening of Arceuthobium oxycedri (Dwarf Mistletoe) of Juniper Forest of PakistanMudassir Asrar Zaidi, Ahsan Huda, Sidney A. CrowThe local population of Balochistan, Pakistan considers the Juniperus excelsa an important medicinal plant. The species is facing a grave threat by a parasitic and epiphytic angiosperm, dwarf mistletoe, Arceuthobium oxycedri (DC) M. Bieb (Viscaceae). The methanolic extract of A. oxycedri was studied for its chemical composition and biologically active compounds for the first time. The extract was assayed for … …OnLine Journal of Biological Sciences, Vol. 6, Issue 2 · 31 Dec 2006 · 7,004 accessesView PDF Cite

Research ArticleOpen accessIn the abstractRapamycin Inhibits Cystogenesis by Cystic Epithelial Cells Derived from Human Autosomal Dominant Polycystic KidneysGerard Elberg, Teresa V. Lewis, Lijuan Chen, Martin A. TurmanAutosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders and carries a high health burden since it progresses to renal failure in half of the afflicted individuals by the 6th decade of life. Currently, there is no effective treatment to slow the progression of ADPKD. Rapamycin, a drug most commonly used as an immunosuppressive agent … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,105 accessesView PDF Cite

Research ArticleOpen accessIn the abstractClozapine and its Major Stable Metabolites, N-desmethylclozapine and Clozapine N-oxide do not Affect Human Bone Marrow Stromal Cells in vitroAvril Pereira, Brian DeanTreatment of refractory schizophrenia with the atypical antipsychotic drug clozapine is associated with life-threatening agranulocytosis, characterised by a drop in neutrophil count. Theoretically, toxicity may be accounted for by direct action of parent drug or one of its stable metabolites on bone marrow stroma given importance of these cells to neutrophil maturation. Effects of clozapine, N-desmethylclozapine and clozapine N-oxide on … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 1 · 31 Mar 2006 · 7,111 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordUltrastructural and Circadian Morphometric Characteristics of Rat Pinealocytes Under Physiological and Toxic ConditionsAnna I. Anurkina, David A. Areshidze, Maria A. Kozlova, Valery P. ChernikovCarbon tetrachloride (CCl₄) exhibits pronounced neurotoxic effects following acute or chronic exposure. Recent studies indicate that the pineal gland responds to CCl₄ intoxication by altering its secretory function, although detailed ultrastructural changes in pinealocytes remain inadequately investigated. This research addresses the urgent need to elucidate the mechanisms of CCl₄ toxicity on the pineal gland, which could contribute to developing strategies … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 1 Jun 2026 · 1,174 accessesView PDF Cite

Case ReportOpen accessAll words, across the recordEffects on the Immune System of a Three-Month Consumption of an Extremely Diverse Probiotic Yogurt: Decrease of Serum Alpha-N-Acetylgalactosaminidase Activity, Detoxification and Gut Microbiota NormalizationJerry Blythe, Marco RuggieroIn this study, we describe the changes associated with the consumption of an extremely biodiverse probiotic yogurt in a 55-year-old female from South Vietnam. In August 2019, the subject voluntarily embarked on a three-month nutritional experience and decided to share her results with the goal of advancing scientific knowledge in the field of nutritional health. Consumption of this biodiverse probiotic … …American Journal of Immunology, Vol. 16, Issue 1 · 22 Oct 2020 · 9,699 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordEffects of Total Dissolved Solids on Aquatic Organisms: A Review of Literature and Recommendation for Salmonid SpeciesPhyllis K. Weber-Scannell, Lawrence K. DuffyTotal dissolves solids (TDS) are naturally present in water or are the result of mining or some industrial treatment of water. TDS contain minerals and organic molecules that provide benefits such as nutrients or contaminants such as toxic metals and organic pollutants. Current regulations require the periodic monitoring of TDS, which is a measurement of inorganic salts, organic matter and … …American Journal of Environmental Sciences, Vol. 3, Issue 1 · 31 Jan 2007 · 23,417 accessesView PDF Cite