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Research ArticleOpen accessIn the abstractIdentification of Novel Human Immunodeficiency Virus-1 Integrase Inhibitors by Shape-Based Virtual ScreeningT.K. Omprakash, A. Thamarai Selvan, A. Shahul Hameed, S.P. GeethaProblem statement: Human Immunodeficiency Virus-1 (HIV-1) is causative agent of the immune system disease, Acquired Immune Deficiency Syndrome (AIDS). Majority of anti-HIV drugs target reverse transcriptase and protease enzymes. Toxicity and development of multidrug resistant HIV-1 virus strains are the reasons for studying new targets in HIV-1 replication process for identifying novel inhibitor with low toxicity and high activity. Approach: … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Dec 2010 · 7,191 accessesView PDFCite
Research ArticleOpen accessIn the abstractScreening of Actinomycete Isolates from Niche Habitats in Manipur for Antibiotic ActivityDebananda S. Ningthoujam, Suchitra Sanasam, Salam NimaichandProblem statement: The exhaustion of the usual terrestrial sources and the rise of resistant pathogens dictate the search for novel actinomycetes and new antibiotics. In this context, niche habitats such as caves, pristine forests, lakes, rivers, and other wetlands, high salt environments, marine ecosystems and endophytic niches are promising targets for survey of bioactive actinomycetes. Approach: Actinomycetes were isolated from … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 4 · 31 Dec 2009 · 7,765 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibiotic Resistance of Escherichia Coli Isolated From Poultry and Poultry Environment of BangladeshMuhammad Ali Akond, S.M.R. Hassan, Saidul Alam, Momena ShirinProblem statement: Increased emergence in microbial resistance to antibiotics is a growing problem in Bangladesh, a tropical country with a large agrarian population having limited medical facilities. Wide spread use of antimicrobials in poultry farming here is a concern of multi-drug microbial resistance development that can potentially be transmitted to human pathogens even from non-pathogenic carrier strains. Attempt was made … …American Journal of Environmental Sciences, Vol. 5, Issue 1 · 28 Feb 2009 · 11,762 accessesView PDFCite
Research ArticleOpen accessIn the abstractAntibacterial and Antioxidant Activities of Typhonium Flagelliforme (Lodd.) Blume TuberSyam Mohan, Ahmad Bustamam Abdul, Siddig Ibrahim Abdel Wahab et al.Problem Statement: Multiple drug resistance in human pathogenic micro organisms has developed due to indiscriminate use of modern antimicrobial drugs generally used in the management of infectious diseases. This increases the importance of exploiting the natural sources instead modern drugs. Approach: The antibacterial and antioxidant activity of different extracts from of Typhonium flagelliforme (L.) Blume tuber (family: Araceae) commonly called … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 10,420 accessesView PDFCite
Research ArticleOpen accessIn the abstractBiochemical and Genetic Responses of Fungi to the Toxic Effect of Synthetic and Natural FungicidesMarÍa-Elena Báez-Flores, Rosalba Troncoso-Rojas, Martin-Ernesto Tiznado-HernándezThe objective of the present review is to analyze the molecular basis of fungicide resistance mechanism to both synthetic fungicides and the natural fungicides isothiocyanates. The review is focused mainly on Alternaria sp., but whenever available, similar studies in other fungi have been included. Fungal resistant strains to dicarboximide and phenylpyrrole fungicides have been found to contain mutations in one … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,118 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordConstruction of Recombinant Bioleaching Bacteria Thiobacillus ferrooxidans with Fluoride-Resistant ActivityYun-Chang Cao, Hong-Bo Wen, Nan Hu et al.Thiobacillus ferrooxidans is an important bioleaching bacterium, widely used in leaching, recovery of low-grade metals and environmental bioremediation. In bio-metallurgy industry, fluoride existing in some hard rock uranium deposits in south China severely affects the bacteria viability and inhibit leaching reproduction. In this study, the flr-4 gene that has strong resistance to fluorine ion in Caenorhabditis elegans, was cloned into … …American Journal of Biochemistry and Biotechnology, Vol. 14, Issue 2 · 23 May 2018 · 11,341 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordBrevibacillus Thermoruber 9X-GLC, Bacteria Isolated from Hot Compost, Producer of a Beta-Glucosidase Resistant to Glucose InhibitionAlejandro Sosa-Peinado, María Eugenia Hidalgo-Lara, Miguel Ángel Plascencia-Espinosa et al.The thermotolerant strain Brevibacillus thermoruber 9X-GLC produces large amounts of β-D-glucosidase and cellobiohydrolase when grown on cellobiose and avicel. 9X-GLC was isolated from hot compost of sugarcane bagasse and filter mud and selected for its high enzymatic activity from a Bacilli collection of 77 isolates from soils and compost. Culture supernatants and ultrafiltered concentrates from shaken flask cultures of 9X-GLC … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 4 · 20 Oct 2017 · 8,153 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordPrediction of Seismic Active Earth Pressure Using Curved Failure Surface with Localized StrainHemanta HazarikaProblem statement: Correct evaluation of the earth pressure against retaining structure during earthquake is essential for the safe and economic design of geotechnical structures. Progressive deformation in the backfill and the assumed shape of failure wedge affect the calculated values of seismic earth pressures. However, no research until now is available that considers both of these two factors in an … …American Journal of Engineering and Applied Sciences, Vol. 2, Issue 3 · 30 Sep 2009 · 7,547 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordDifferential Gene Expression of Peroxide Resistant Protein (AhpC) in Planktonic and Biofilm State of Uropathogenic Escherichia coli CellsOmar Sadik Shalal, Ani-Simona SevastreThe gastrointestinal tract seems to be the primary reservoir of Uropathogenic Escherichia coli (UPEC) in humans. UPEC strains harbor the Urinary Tract (UT) and cause Urinary Tract Infections (UTI) which might represent a serious threat to human life. To counteract with the damage caused by the Reactive Oxygen Species (ROS), bacterial strains produce various enzymes and proteins like Alkyl hydroperoxide … …American Journal of Biochemistry and Biotechnology, Vol. 19, Issue 3 · 13 Oct 2023 · 5,324 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordAntimicrobial Resistance Pattern and Characteristics of Integrons in Escherichia Coli Strains Isolated from Aquatic Retail Products in Zhejiang Province, ChinaTing Yu, Han Jiang, Hui Cheng et al.The aquatic retail products are among the potential reservoirs of antimicrobial resistant microorganisms. The main objective of this study was to analyze the antimicrobial susceptibility patterns and integrons and their associated Gene Cassettes (GCs) of Escherichia coli isolates from aquatic retail products. E. coli isolates were obtained from 450 aquatic retail products samples at different markets in Zhejiang Province, China. … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 4 · 21 Dec 2020 · 6,103 accessesView PDFCite