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Research ArticleOpen accessIn the abstractThe -863 TNF-α Polymorphism and Primary Open Angle Glaucoma in EgyptiansWalaa Bayoumie Abdulwahhab El Gazzar, Shaymaa Mohamed Abd El Rahman, Mohamed Nagy Elmohamady et al.Growing evidence indicates that TNF-alpha is involved in the pathogenesis of POAG in several ways, primarly by induction of retinal ganglion cells apoptosis and therefore optic nerve degeneration. TNF-alpha and POAG relationship has been studied at the genetic level with variable results in different populations. The transcription rate and the release of the TNF-alpha cytokine have been reported to be … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 2 · 1 Jun 2017 · 7,360 accessesView PDFCite
Research ArticleOpen accessIn the abstractMechanism of Mulberry's Effect on Intestinal Flora and MotilityHuizhen Zhao, Shijing Xie, Yuwen Li et al.Studies have indicated that mulberry consumption promotes intestinal motility and alleviates constipation, but the specific mechanism remains unclear. This study adopted a constipation mouse model to empirically analyze the effects of mulberry on intestinal motility, gut microbiota composition, and neurotransmitter levels, aiming to elucidate its mechanism of action. Key findings are as follows: 1) Compared with the model group, the … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 2 · 2 Jul 2026 · 1,198 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Acute Oral Toxicity Induced by Tablets Based on Ethanolic Extract of Salvia dumetorum Leaves in Experimental RatsYana Levaya, Karakoz Badekova, Mussa Zholdasbayev, Gayane AtazhanovaThe aim of this study was to assess the acute oral toxicity of a solid dosage form based on Salvia dumetorum Andrz. ex Besser leaf extract (SDT5) in experimental rats. Acute toxicity was evaluated over a 14-day observation period following a single oral administration at three dose levels (500 mg/kg, 1000 mg/kg, and 2000 mg/kg), prepared in 0.5 mL of … …OnLine Journal of Biological Sciences, Vol. 26, Issue 2 · 23 Jun 2026 · 1,245 accessesView PDFCite
Research ArticleOpen accessIn the abstractAluminium-Induced Hepatotoxicity and the Protective Role of Withania somnifera (Ashwagandha) in Wistar RatsAnchana Babu, Rekha D Kini, Nayanatara Arun Kumar, Megha GokulAluminium is a widely distributed environmental contaminant whose chronic exposure leads to accumulation in multiple organs, including the liver, resulting in oxidative stress and tissue damage. When reactive oxygen species production exceeds the body's antioxidant defense capacity, cellular injury ensues — a mechanism central to aluminium-induced hepatotoxicity. Withania somnifera (Ashwagandha), an evergreen herb of the Solanaceae family widely cultivated in … …OnLine Journal of Biological Sciences, Vol. 26, Issue 1 · 6 Apr 2026 · 1,451 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of the Cresacin Feed Additive on the Digestibility of Nutrients, Productivity and Egg Quality in Egg Laying QuailsDjunaydi Gayirbegov, Gayaz EngurazovThe purpose of the article was to study the effect of the Cresacin feed additive on the digestibility and use of nutrients in the diet of egg laying quails, as well as their egg productivity and quality. The experiment was carried out on 600 heads of one-day-old quails of the Estonian breed, which were divided into four similar groups of … …American Journal of Animal and Veterinary Sciences, Vol. 18, Issue 1 · 6 Mar 2023 · 5,287 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Bromocriptine and Nano-Bromocriptine on Egg Quality Parameters of Late Laying HensAhmed Dawod, Noha Osman, Hanim S. Heikal, Hamada MahboubThe study was conducted to determine the effect of bromocriptine and nano-bromocriptine on external and internal egg qualities of late laying hens. A total of 150 Novo-gene brown strain hens of 70 weeks of age were selected from a commercial laying farm. The birds were divided randomly into three groups, with 50 birds in each. The first group was given … …American Journal of Pharmacology and Toxicology, Vol. 16, Issue 1 · 30 Sep 2021 · 6,756 accessesView PDFCite
Research ArticleOpen accessIn the abstractImpact of Vitamin B17 Against Growth of Colitis Bearing Mice Induced Variations in Colon Structure, AFP, CEA and PCNA ImmunoreactivityGihan Hosny Abd Elsamie, Sabah Gaber El-Banna, Ehab Tousson et al.Colitis alludes to inflammation of the internal coating of the colon that accompanied clinically through abdominal pains, diarrhea, weight loss, nausea. Current study aimed to study the impact of vitamin B17 against growth of colitis bearing mice induced variations in colon structure, AFP, CEA and PCNA immune reactivity. Forty female Swiss albino mice separated into 4 groups (Control, vitamin B17, … …OnLine Journal of Biological Sciences, Vol. 21, Issue 3 · 23 Aug 2021 · 6,401 accessesView PDFCite
Research ArticleOpen accessIn the abstractTherapeutic Effects of Turnera diffusa Extract Against Amitriptyline-Induced Toxic Hepatic InflammationAhmed F. Hasan, Thulfiqar F. Mutar, Ehab Moustafa Tousson, Shatha Ghazi FelembanTricyclic Antidepressants Including Amitriptyline (AMI), stop the reabsorption of norepinephrine and serotonin, so the levels of transmitters is elevated in the brain to lead to several side effects. Therefore, current study aimed to assay liver dysfunction that attended by AMI administration and monitoring of damiana Turnera diffuse role as adjuvant therapy to improving amitriptyline hepatic effects in male rats. 60 … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 29 Jun 2021 · 8,291 accessesView PDFCite
Research ArticleOpen accessIn the abstractIntravenous Injection of Umbilical Cord-Derived Mesenchymal Stem Cells Improved Regeneration of Rat Liver after 2AAF/CCl4-Induced InjuryIsabella Kurnia Liem, Reni Oktavina, Zakiyah et al.The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of application rather than direct to the target organ, such as portal vein or splenic vein, since the most of MSC will be trapped in the lung … …OnLine Journal of Biological Sciences, Vol. 21, Issue 2 · 10 Jun 2021 · 6,784 accessesView PDFCite
Research ArticleOpen accessIn the abstractVariations in Pathogenicity and Molecular Characterization of Infectious Bursal Disease Virus (IBDV) In EgyptMahmoud E. Sedeik, Ashraf M. Awad, Heba Rashed, Wael K. ElfeilInfectious bursal disease consider a vital threat to poultry industry worldwide and It has special potentiality in Egypt as the country become endemic with several clades from avian influenza from both types highly pathogenic (H5N1 and H5N8) and low pathogenic one (H9N2). The Egyptian government depends on the inactivated vaccine strategy to control avian influenza and any infection with IBD … …American Journal of Animal and Veterinary Sciences, Vol. 13, Issue 2 · 18 May 2018 · 8,485 accessesView PDFCite