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92 results for “Drug-Resistance”
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Research ArticleOpen accessIn the abstractAntibiogram-Derived Radial Decision Trees: An Innovative Approach to Susceptibility Data DisplayRocco J. Perla, Paul P. BelliveauHospital antibiograms (ABGMs) are often presented in the form of large 2-factor (single organism vs. single antimicrobial) tables. Presenting susceptibility data in this fashion, although of value, does have limitations relative to drug resistant subpopulations. As the crisis of antimicrobial drug-resistance continues to escalate globally, clinicians need (1) to have access to susceptibility data that, for isolates resistant to first-line … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 6,504 accessesView PDFCite
Review ArticleOpen accessIn the abstractHost Receptor Immunomodulation in Response to Shigella Surface Antigens: An Insight for Vaccine DevelopmentAshim K. Bagchi, Rushita A. Bagchi, Dipak K. Hens et al.Shigellosis, caused by Shigella is the most common cause of bacillary dysentery. The disease is associated with high morbidity and mortality rate owing to its multiple drug resistance. Hence recovery from the disease would primarily depend on the development of an effective immune-modulator for strong mucosal immune response. The role of cellular immunity may be a critical factor in protection … …American Journal of Immunology, Vol. 11, Issue 2 · 21 Jun 2015 · 6,755 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetection of Hepatitis C Virus Resistant Mutants in the era of Direct Acting AntiviralsLivia Maria Gonçalves Rossi, Paula RahalHepatitis C Virus (HCV) infects millions of people and represents an important public health problem in different regions of the world. Drug resistance is a major challenge for HCV-infection related control. Importantly, the arrival of a plethora of novel, more powerful drugs has revolutionized the field of HCV treatment. Here, we discuss the relevance of identification of HCV resistant mutants … …American Journal of Infectious Diseases, Vol. 10, Issue 4 · 7 Jan 2015 · 6,433 accessesView PDFCite
Research ArticleOpen accessIn the abstractPotential Role of Migratory Quail in Spreading of Some Zoonotic Pathogens in EgyptAhmed I. Youssef, Dalia H. MansourThis study aimed to illustrate the potential role of wild migratory quails in the epidemiology of some zoonotic pathogens in Egypt. Ninety four apparently healthy migratory quails were collected from public markets after being trapped during hunting season from the North Sinai. Oral, cloaca and organs (liver, lung and heart) swabs were collected for bacteriological and viral examination. Bacteriological examination … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 13 Dec 2014 · 7,532 accessesView PDFCite
Research ArticleOpen accessIn the abstractMOLECULAR CHARACTERIZATION ON THE BASIS OF HA, NA AND M GENE REVEALED CHANGES IN CRITICAL AMINO ACID POSITIONS OF INFLUENZA A (H3N2) VIRUS CIRCULATING IN INDIA DURING 2011-2013Sachin Kumar, Shashi Khare, Bano Saidullah et al.Influenza a (H1N1) virus is responsible for acute respiratory infection in human, which occasionally causes epidemic and rarely a pandemic. Full length DNA sequencing of HA, NA and M gene of H3N2 virus from year 2011-2013 was performed for determination of the circulating strains in India along with monitoring status of various mutations associated with drug resistance and virulence. Genetic … …American Journal of Infectious Diseases, Vol. 10, Issue 3 · 18 Oct 2014 · 6,842 accessesView PDFCite
Research ArticleOpen accessIn the abstractTHE EFFECT OF DIABETES MELLITUS ON THE CLINICAL AND MICRO-BIOLOGICAL OUTCOMES IN PATIENTS WITH ACUTE PYELONEPHRITISKathleen Lynch, Veena Venugopalan, Levita HidayatThere is some published evidence which suggests that the clinical outcomes and pathogens associated with Acute Pyelonephritis (AP) differ between diabetics and non-diabetics. However, current guidelines do not make treatment distinctions based on Diabetes Mellitus (DM) status. The objectives of this study were to identify the microbiological and clinical characteristics of hospitalized patients with AP and investigate differences between patients … …American Journal of Infectious Diseases, Vol. 10, Issue 2 · 6 May 2014 · 7,378 accessesView PDFCite
Research ArticleOpen accessIn the abstractINHIBITORY ACTIVITY OF POTENTOX AGAINST DNA GYRASE OF ENTEROBACTERIACEAEManu Chaudhary, Anurag PayasiDNA gyrase, a type II topoisomerase catalyzes the supercoiling of relaxed closed circular DNA. In this report we evaluated the in vitro inhibitory effect of non antibiotic adjuvant compounds disodium edetate and sodium citrate against supercoiling activity of bacterial DNA gyrase. Further, we assessed the effect of different drugs alone and in combination with one or more adjuvants in overcoming … …American Journal of Infectious Diseases, Vol. 10, Issue 1 · 8 Feb 2014 · 7,291 accessesView PDFCite
Research ArticleOpen accessIn the abstractQuercetin in Dimethyl Benzanthracene Induced Breast Cancer in RatsNatla Sashidhar Reddy, Parthasarathy Nirmala, Natesan Chidambaram, Pammi Ashok kumarProblem statement: Vincristine a commonly used anticancer agent in the treatment of breast cancer results in serious adverse effects like teratogenicity, neurotoxicity and carcinogenicity on long term use. Drug resistance is also a common problem encountered with vincristine. Hence the effect of flavonol quercetin, a known antioxidant with no known documented adverse effect was tried in treatment of DMBA induced … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 30 Jul 2012 · 8,141 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign, Synthesis, Biological Screening and Structure Activity Relationship Study of 4, 6-Dimethyl-2-(Substituted) Mercapto-3-(Substituted) Pyridines as Anti Tubercular AgentsMehul M. Patel, Mahesh T. ChhabriyaProblem statement: Tuberculosis is a leading global mortality factor which has not been effectively controlled, with 1.7 million deaths per year and 8.9 million new cases. Aerobic microbe Mycobacterium tuberculosis H37Rv (MTB) is the causative agent of tuberculosis. Although many active antitubercular agents have since been developed, drug resistance will continue to be a problem. Therefore, there is a clear … …American Journal of Infectious Diseases, Vol. 7, Issue 3 · 3 Nov 2011 · 7,432 accessesView PDFCite
Research ArticleOpen accessIn the abstractDetection of Extended-Spectrum β Lactamases and AmpC β-Lactamase Production in Escherichia coli Causing Urinary Tract Infection among HIV and Non-HIV PatientsPadmavathy Kesavaram, Padma Krishnan, Rajasekaran SikhamaniProblem statement: Opportunistic infections have been documented as a leading cause of morbidity among HIV patients. Gram negative pathogens that elaborate beta-lactamases have been reported to be associated with increased morbidity and mortality, especially amongst immunocompromised patients on intensive care and high-dependency units. The most common mechanism of β-lactam drug resistance in Escherichia coli include ESBL, AmpC production. Approach: In … …Current Research in Medicine, Vol. 2, Issue 1 · 18 Aug 2011 · 7,837 accessesView PDFCite