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Research ArticleOpen accessIn the abstractInvestigations in the molecular events of Transitional Cell Carcinoma of the BladderH.S. Kadhim, A.S. Abdulamir, R.R. Hafidh et al.Problem Statement: Transitional Cell Carcinoma (TCC) of the bladder is a significant health problem worldwide. The molecular mechanisms of tumor development and progression are complicated but likely involve the interaction of tumor suppressor genes, oncogenes, cell cycle regulatory proteins and other factors. Hence this study tries to explore the role of p53, bcl-2, c-myc and Ki-67 in TCC of the … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 4 · 31 Dec 2008 · 7,528 accessesView PDFCite
Research ArticleOpen accessIn the abstractCocaine: A Catalyst for Human Immunodeficiency Virus-Associated DementiaNavneet K. Dhillon, Milind Gadgil, Andy Rahardja et al.Injection drug use has been recognized as a major risk factor for AIDS from the outset of the epidemic. Cocaine, one of the most widely abused drugs in the United States can both impair the functions of macrophages and CD4+ lymphocytes and also activate HIV-1 expression in these cells. Cocaine is a multifactorial agent that acts globally to impair the … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 7,587 accessesView PDFCite
Research ArticleOpen accessIn the abstractBiochemical and Genetic Responses of Fungi to the Toxic Effect of Synthetic and Natural FungicidesMarÍa-Elena Báez-Flores, Rosalba Troncoso-Rojas, Martin-Ernesto Tiznado-HernándezThe objective of the present review is to analyze the molecular basis of fungicide resistance mechanism to both synthetic fungicides and the natural fungicides isothiocyanates. The review is focused mainly on Alternaria sp., but whenever available, similar studies in other fungi have been included. Fungal resistant strains to dicarboximide and phenylpyrrole fungicides have been found to contain mutations in one … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,118 accessesView PDFCite
Research ArticleOpen accessIn the abstractExtraction of Genomic DNA Using Magnetic Nanoparticles (Fe3O4) as a Solid-Phase SupportZ. M. Saiyed, C. N. RamchandMagnetic separation technology, using magnetic particles, is quick and easy method for sensitive and reliable captures of specific proteins, genetic material and other biomolecules. The current paper describes a universal genomic DNA extraction method optimized in our laboratory using magnetic nanoparticles as a solid phase adsorbent. The yields of the isolated DNA with magnetic method were higher or equivalent to … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 9,826 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmunodeficient Parameters in the HIV-1 Transgenic Rat ModelSulie L. Chang, Frank Ocasio, Jose A. BeltranRecently an HIV-1 transgenic (HIV-1Tg) rat model was created that carries a gag-pol-deleted HIV-1 genome under the control of the HIV-1 viral promoter. However, other viral proteins are expressed in most organs and tissues, and are found in the circulating blood. Since HIV-1 targets the immune system in humans, we examined two immunological parameters, leukocyte-endothelial adhesion (LEA) and inflammatory cytokine … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,834 accessesView PDFCite
Research ArticleOpen accessIn the abstractNutritional control of HIV-AIDS-A case for SeleniumParisa Kalantari, Hema Vunta, Umamaheswari D. Palempalli et al.Selenium (Se) is a micronutrient that is incorporated into proteins. Some of the selenoenzymes such as GPXs and thioredoxin reductases exhibit glutathione peroxidase-dependent activities towards organic and inorganic peroxides. Thus, selenoenzymes play a pivotal role in mitigating oxidative stress caused by accumulation of peroxides. In this respect, selenoproteins may interfere with the transcription-driven by oxidative stress-dependent signaling mechanisms to influence … …American Journal of Infectious Diseases, Vol. 3, Issue 4 · 31 Dec 2007 · 7,344 accessesView PDFCite
Research ArticleOpen accessIn the abstractRedox Sensing and Cardiac Myocyte Loss: Some Recent InsightsShyamal K. GoswamiGeneration of reactive oxygen-nitrogen species (ROS/RNS) has long been ascribed to pathophysiological conditions like ageing, neurodegenerative and cardiovascular disorders. However, more recent evidences suggest that while generation of ROS/RNS at a higher threshold is deleterious, at a lower dose these can act as second messengers, influencing specific cellular events like cell growth and differentiation, embryonic development, protection against ischemic injuries … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,349 accessesView PDFCite
Research ArticleOpen accessIn the abstractExpression of Toll-like Receptors (TLRs) and Nucleotide-binding Oligomerization Domain (NODs) in murine peritoneal macrophages on in vitro treatment with Thymosin α 1Shikha Tarang, Ajit SodhiThymosin α 1 (Tα1) treatment of murine peritoneal macrophages in vitro induces the expression of TLRs and Nod2 proteins. Enhanced expressions of TLR2, -4, -5, -6, -7, -8, -9 and Nod2 were observed by RT-PCR and western blotting. Expression of downstream signaling molecules - MyD88, IRAK1, TRAF6, IRF3 were also up regulated on treatment with Tα1. It was also observed … …American Journal of Immunology, Vol. 3, Issue 1 · 30 Jun 2007 · 7,150 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of a DNA Vaccine for Immunocontraceptive Potential Against Zona Pellucida Glycoproteins in CattleC.A. Foley, S.M. Boyle, R.E. Pearson, F.C. GwazdauskasHolstein cows were administered zona pellucida (ZP) DNA vaccine and used to determine the potential of recombinant rabbit ZP glycoproteins (rZP) as immunocontraceptive antigens. Zona pellucida proteins were purified and quantified. Cows were assigned to one of four treatment groups in which plasmids encoding rabbit ZP proteins were administered, i.d., using a gene gun (ZP55, n=2; ZP75, n=2; Hep55, n=2; … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 1 · 31 Mar 2007 · 6,888 accessesView PDFCite
Research ArticleOpen accessIn the abstractHigh Concentrations of Glucose can Activate or Inhibit Human Erythrocyte Aminolevulinate Dehydratase in vitro Depending Exposure TimeJ. C. Soares, D. Gabriel, V. Folmer et al.Hyperglycemia can cause oxidative stress and inactivate susceptible enzymes. In the present investigation we examined whether short-term incubations (24 or 48 h) with high concentrations of glucose (10-200 mmol L-1) inhibit ALA-D from human erythrocytes. Incubations of erythrocytes for 24 h with glucose (10 up to 40 mmol L-1) resulted in an increase of δ-ALA-D activity (P<0,001). Incubations of erythrocytes … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 6,686 accessesView PDFCite