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77 results for “toxic effects”
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Review ArticleOpen accessIn the abstractSelected Genotoxic Impurities Profiling During WFI Qualification to Control Carcinogenesis in Large Volume ParenteralsMohabbat UllahWater For Injections (WFI) which is the main vehicle of Large Volume Parenterals (LVPs) should be free from trace amount of genotoxic impurities. This review gives emphasis on quantification of genotoxic trace metals during qualification of WFI in LVPs manufacturing unit. According to ICH guidelines, impurities related to drug substances are classified into three main categories: Organic impurities, inorganic (elemental) … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 1 · 27 May 2015 · 7,710 accessesView PDFCite
EditorialOpen accessIn the abstractAMYOTROPHIC LATERAL SCLEROSIS: HOW TO UNDERSTAND SUCH DIVERSE AND SO ENTANGLED PHYSIOPATHOLOGY?Carlos Henrique Melo Reis, Marco Orsini, Marco Antônio Araujo Leite et al.When in 1865, JeanMartin Charcotreported patients with progressive muscular atrophysuperimposedwith spasticity of inexorable evolution as result of combinedlesions of the anterior horn and lateral column of the spinal cord, hecertainly inaugurated an attempt on the comprehension of one of the mostcomplexes neurological clinical conditions, which until today persists withimmense voids on their comprehension, regardless of the enormous advancesachieved. Astime went … …Current Research in Medicine, Vol. 5, Issue 2 · 16 Feb 2015 · 7,151 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Effect of Galactomannan Extracted from Iraqi Lycium barbarum L. Fruits against Alloxan-Induced Diabetes in RatsAdnan J.M. Al-FartosyLycium barbarum L. (Solanaceae) is widely used in Iraqi Ayurvedic medicine for the treatment of diabetes mellitus. The present investigation was done to evaluate the effects of polysaccharide (galactomannan) from Lycium barbarum L. Fruits (GLBF) on serum blood glucose, serum lipid profile and lipid peroxidation and antioxidant defence system in liver and kidney of alloxan-induced diabetic rats. GLBF was found … …American Journal of Biochemistry and Biotechnology, Vol. 11, Issue 2 · 15 Dec 2014 · 7,657 accessesView PDFCite
Research ArticleOpen accessIn the abstractDecolorization of Distillery Effluent by Thermotolerant Bacillus subtilisSoni Tiwari, Rajeeva Gaur, Priyanka Rai, Ashutosh TripathiProblem statement: Ethanol production from sugarcane molasses generate large volume of effluent containing high Biological Oxygen Demand (BOD) and Chemical Oxygen Demand (COD) along with melanoidin, a color compound generally produced by “Millard reaction”. Melanodin is a recalcitrant compound degraded by specific microorganisms having ability to produce mono and di-oxygenases peroxidases, phenoxidases and laccases, are mainly responsible for degradation of … …American Journal of Applied Sciences, Vol. 9, Issue 6 · 14 Mar 2012 · 7,652 accessesView PDFCite
Research ArticleOpen accessIn the abstractHAZOP Analysis Management System with Dynamic Visual Model AidNan Bin Mad Sahar, Syahril Ardi, Suzuki Kazuhiko et al.Problem statement: Ensuring safe operability and minimizing risk is the key component to prevent negative impact in all industries dealing with toxic, reactive, flammable and explosive. Hazard and Operability (HAZOP), a preliminary and systematic approach for identifying hazards has been unquestionably successful in reducing incidents by mitigating the consequence of major accident in the industries process facility. However, laborious work, … …American Journal of Applied Sciences, Vol. 7, Issue 7 · 31 Jul 2010 · 7,992 accessesView PDFCite
Research ArticleOpen accessIn the abstractChange in Growth Performance and Liver Function Enzymes of Broiler Chickens Challenged with Infectious Bursal Disease Virus to Dietary Supplementation of Methionine and ThreonineElham Maroufyan, Azhar Kasim, Seyed Reza Hashemi et al.Problem statement: The aim of this study was to verify the effects of methionine and threonine supplementations higher than the NRC recommendation on growth performance, liver function enzymes, blood parameters and immune tissues of broiler chickens challenged with infectious bursal disease. Approach: A total of 450 day-old male broiler chicks were assigned to nine groups. Chickens were fed by three … …American Journal of Animal and Veterinary Sciences, Vol. 5, Issue 1 · 31 Mar 2010 · 9,472 accessesView PDFCite
Research ArticleOpen accessIn the abstractCamel's Milk Protects Against Cadmium Chloride Induced Toxicity in White Albino RatsFahaid Al-Hashem, Mohammad Dallak, Nabil Bashir et al.Problem statement: Cadmium is one of the most dangerous occupational and environmental toxins. It is found in drinking water, atmospheric air and even in food. Cadmium is reported to be very toxic to biological systems. Until now in treating intoxication with this metal, chelating Compounds have been used, burdened with numerous undesirable symptoms. For this reason, many researches are carried … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 3 · 30 Sep 2009 · 9,314 accessesView PDFCite
Research ArticleOpen accessIn the abstractCamel's Milk Protects against Aluminum Chloride-Induced Toxicity in the Liver and Kidney of White Albino RatsFahaid Al-HashemProblem statement: Aluminum chloride (AlCl3) is commonly used in daily life but it can be potentially toxic. Therefore, the present study was carried out to investigate the protective effects of camel’s milk against aluminum-induced biochemical alterations and oxidative stress in the liver and kidney of white albino rats. Approach: White albino male rats (230-250 g) were divided into three groups … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 3 · 30 Sep 2009 · 10,376 accessesView PDFCite
Research ArticleOpen accessIn the abstractCadmium Induced Changes in Metabolic Function of Mitochondrial Isolated from Potato Tissue (Solanum tuberosum L.)Chagra Ali, Djebar Mohammed Réda, Rouabhi Rachid, Berrebbah HouriaProblem statement: Cadmium is highly toxic at low concentrations, but the mechanism of its toxicity is still not understood particularly at the cellular and subcellular level. Approach: In this study we examined the effects of cadmium on the oxidophosphorylation properties of mitochondria isolated from potatoes. Results: Cadmium strongly disturbed the respiratory metabolism of mitochondria isolated especially in the transfer of … …American Journal of Biochemistry and Biotechnology, Vol. 5, Issue 1 · 31 Aug 2009 · 7,842 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Study of the Essential Oils of Four Sudanese Accessions of Basil (Ocimum basilicum L.) Against Anopheles Mosquito LarvaeAzhari H. Nour, Salah A. Elhussein, Nour A. Osman et al.Problem statement: Certain basil essential oils were claimed to have a larvicidal activity towards mosquito's larvae. To test this claim the essential oils of four accessions of basil grown in Sudan were selected and tested for Anopheles larvae. Malaria is the major health problem in the Sudan and the whole country is now considered endemic, with varying degrees, about 35,000 … …American Journal of Applied Sciences, Vol. 6, Issue 7 · 31 Jul 2009 · 8,833 accessesView PDFCite