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EditorialOpen accessIn the abstractGLUTATHIONE: A POSSIBLE LINK TO AUTOPHAGY IN SYSTEMIC LUPUS ERYTHEMATOSUSDilip Shah, Swapan K. NathIncreased free radical formation and altered redox state are of fundamental importance in the pathogenesis of autoimmune diseases including Systemic Lupus Erythematos (SLE). Free radicals are mainly derived from oxygen (Reactive Oxygen Species/ROS) and nitrogen (Reactive Nitrogen Species/RNS) at mitochondria, cellular membranes and the endoplasmic reticulum membrane as physiological responses to a variety of internal and external stress (Shah et … …American Journal of Immunology, Vol. 10, Issue 3 · 3 Sep 2014 · 12,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractA SHORT INTERFERING RNA MOLECULAR BEACON FOR THE ATTENUATION OF MYCOBACTERIAL INFECTIONRemo George, Kathy Nugent, Norman Bolus et al.The ability of the pathogen Mycobacterium Tuberculosis (MTB) to invade and survive within macrophages of granulomas is attributed to the product of the Mammalian Cell Entry (MCE) operon whose gene, mce4A, encodes a cholesterol transporter that transports host lipids into the bacterium that allows the bacterium to survive during chronic infection. Here, we proposed and tested the hypothesis that a … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 1 · 4 Mar 2014 · 7,774 accessesView PDFCite
Research ArticleOpen accessIn the abstractCASE REPORT OF A PATIENT WITH RARE P.ARG136CYS (APOE2*) MUTATION IN APOLIPOPROTEIN E GENEJana Lisyova, Jan Chandoga, Stanislav Oravec et al.Apolipoprotein E (apoE) is a polymorphic glycoprotein associated with plasma lipoproteins and plays an essential role in the metabolism and clearance of plasma lipids. ApoE can represent the major genetic risk factor in development of premature atherosclerosis, coronary heart disease and late-onset familial and sporadic Alzheimer’s Disease (AD). We present a case report of a 51-year old male with suspected … …OnLine Journal of Biological Sciences, Vol. 14, Issue 1 · 9 Jan 2014 · 7,295 accessesView PDFCite
Research ArticleOpen accessIn the abstractAdiponectin Regulation in Type 2 Diabetic Rats: Effects of Insulin, Metformin and DexamethasoneTamer Ahmed Ismail, Mohamed Mohamed Soliman, Shimaa Ahmed IsmailAdiponectin is a protein synthesized from adipose tissue, increases peripheral glucose utilization in liver and skeletal muscle. Adiponectin expression and secretion are decreased during obesity and insulin resistance. In this study, the effect of insulin, metformin and dexamethasone on serum lipid profiles was examined in Type 2 Diabetic (T2D) rats. T2D was induced by feeding rats a high fat diet … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 23 Nov 2013 · 7,723 accessesView PDFCite
Research ArticleOpen accessIn the abstractFatty Acid Content of Bovine Milkfat From Raw Milk to YoghurtO. O. Santos Júnior, M. R. Pedrão, L. F. Dias et al.Problem statement: The present study aimed to study the evolution of fatty acid content, focusing on rumenic acid content, from raw milk to yoghurt processed from this milk. Approach: Milk samples were collected in a dairy plant in the northwest of Paraná State weekly in January 2011 (Brazilian summer). It processed one truck load of 26,000 L of refrigerated type-C … …American Journal of Applied Sciences, Vol. 9, Issue 8 · 7 Jul 2012 · 7,877 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Correlations Between Mercury Speciation and Dissolved Organic Matter in the Sediment of the Red SeaM. A. Wedyan, F. A. Ababneh, S. Al-RousanThis study addresses the correlations between Hg and organic matter in recent sediment; samples were collected from the Gulf of Aqaba, Red Sea coasts (oligotrophic regions) during 2010. In the present study TOC analyzer was used to determine Total Organic Carbon (TOC) and Total Nitrogen (TN) concentrations and the total amount of mercury (HgT) in sediment samples were analyzed by … …American Journal of Environmental Sciences, Vol. 8, Issue 4 · 21 Jun 2012 · 6,795 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Microbial, Anti-Oxidant and Anti-Ulcerogenic Effects of Shilajit on Gastric Ulcer in RatsMohamed-I. Kotb El-Sayed, Hatem-K. Amin, Ali-G. Al-KafProblem statement: To evaluate the effects and mechanisms of action involved in anti-ulcer, antioxidant and antimicrobial activities of different native shilajit samples. Approach: Shilajit samples were collected in the mountain region of Yemen (Al-Jouf and Rayma), Russia (Tien-Shan) and India (Kumoan). Stomach ulcers were induced in rats by oro-gastric ingestion of ethanol/HCl. Pre-treatment with ranitidine (100 mg kg-1, p.o.) and … …American Journal of Biochemistry and Biotechnology, Vol. 8, Issue 1 · 10 Mar 2012 · 8,996 accessesView PDFCite
Research ArticleOpen accessIn the abstractAltered Reproduction in Clarias gariepinus Exposed to Industrial EffluentsAdeogun Aina Olubukola, Chukwuka Azubuike VictorProblem statement: Reproductive success is a key factor in determining species survival and the unregulated discharge of industrial effluents into rivers and streams in a developing country like Nigeria, can impair reproductive ability in non-target organisms like fish. Fish, generally accumulate contaminants from their environment in their tissues and these can be transmitted through the yolk lipids to the eggs. … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 1 · 21 Feb 2012 · 7,706 accessesView PDFCite
Research ArticleOpen accessIn the abstractSlow Fungal Hydrolysis of Complex Sugar is Responsible for the Use of Sugar as Vehicle for Antifungal DrugsNedosa Ikenna Valentine, Utoh-Nedosa Uchechukwu Anastasia, Dan Danjuma et al.Problem statement: Aspergillus niger strain (UUF 9202) significantly reduced the dormancy period and boosted aggregate germination time in seeds of Tetrapleura tetraptera by 42% in 32 days and produced a net reduction in mean germination time of the seeds to 12 days. A structure-fungitoxicity relationship study of a series of isoflavonoids against Aspergillus niger and Cladosporium cucumerinum showed that a … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 2 Nov 2011 · 7,665 accessesView PDFCite
Research ArticleOpen accessIn the abstractMeat Spoilage Mechanisms and Preservation Techniques: A Critical ReviewD. Dave, Abdel E. GhalyProblem statement: Extremely perishable meat provides favorable growth condition for various microorganisms. Meat is also very much susceptible to spoilage due to chemical and enzymatic activities. The breakdown of fat, protein and carbohydrates of meat results in the development of off-odors, off-flavor and slim formation which make the meat objectionable for human consumption. It is, therefore, necessary to control meat … …American Journal of Agricultural and Biological Sciences, Vol. 6, Issue 4 · 2 Nov 2011 · 54,798 accessesView PDFCite