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99 articles for “Pathogenesis”
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Research ArticleOpen accessIn the abstractThe Role of Nf-Kappa and HDCA and Implication of Oxidative Stress in Airway Inflammation of Chronic Obstructive Pulmonary DiseaseGhada A. Abdallah, Nevine M. Abd-Elfattah, Hala M. Ghanem et al.Oxidative stress has been implicated in the pathogenesis of Chronic Obstructive Pulmonary Disease (COPD), due to its effect on proinflammatory gene transcription. Oxidants/antioxidants imbalance is responsible for disease development. The study was designed to assess oxidative stress and inflammation in COPD patients. The level of TNF-α and IL-8 in sputum and BAL were compared. NF-κB and HDAC were measured in … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 4 Dec 2014 · 6,836 accessesView PDFCite
EditorialOpen accessIn the abstractTo NET or not to NETJadwiga JablonskaBranzk, N., A. Lubojemska, S.E. Hardison, Q. Wang and V. Papayannopoulos et al., 2014. Neutrophils sense microbe size and selectively release neutrophil extracellular traps in response to large pathogens. Nat. Immunol.,15: 1017-1025. DOI: 10.1038/ni.2987 Brinkmann, V., U. Reichard, C. Goosmann, B. Fauler and A. Zychlinsky et al., 2004. Neutrophil extracellular traps kill bacteria. Science, 303: 1532-1535. DOI: 10.1126/science.1092385 Cools-Lartigue, J., … …American Journal of Immunology, Vol. 10, Issue 4 · 3 Dec 2014 · 8,383 accessesView PDFCite
Research ArticleOpen accessIn the abstractPREVALENCE OF AUTOANTIBODIES REVEALS A PREDOMINANT SMA AND ANCA-PR3/MPO PATTERN IN HIV INFECTION AND SMA IN HAV-INFECTED CHILDRENLuz M. Navarta, Carlos A. Espul, Nelson Acosta-RiveroHepatitis A Virus (HAV) and Human Immunodeficiency Virus (HIV) have been associated with development of autoantibodies and autoimmune manifestations in children. Autoimmune Hepatitis (AIH) is particularly aggressive in children/adolescents with a more severe outcome. Thus, studying the mechanisms of virus-related autoimmune disorders in children is a relevant topic of research. We aimed to study the prevalence of autoantibodies in plasma … …American Journal of Immunology, Vol. 10, Issue 3 · 18 Sep 2014 · 7,038 accessesView PDFCite
Research ArticleOpen accessIn the abstractASSOCIATION OF TESTOSTERONE AND CHOLESTEROL LEVEL IN MODULATION OF IMMUNITY AND SEVERITY OF DISEASE IN VISCERAL LEISHMANIASIS PATIENTS-A PRELIMINARY STUDYKrishna Pandey, Dharmendra Singh, Sanjiva Bimal et al.Males are more prone to Visceral Leishmaniasis (VL) as compared to females. The role of androgens in host defence against Leishmania and other pathogens is of considerable interest. This study was aimed to understand a baseline mechanistic understanding of the pathogenesis of visceral leishmaniasis with respect to testosterone. We examined the relationship between serum testosterone and cholesterol levels, antigen induced … …American Journal of Immunology, Vol. 10, Issue 1 · 25 Mar 2014 · 7,073 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Gc-Macrophage Activating Factor in Human Neurons; Implications for Treatment of Chronic Fatigue SyndromeRodney Smith, Lynda Thyer, Emma Ward et al.Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating disease of multifactorial aetiology characterized by immune system dysfunction, widespread inflammation, multisystemic neuropathology and persistent pain. Given the central role of the immune system in the pathogenesis of the syndrome, we studied the effects of a potent modulator of the immune system in in vitro and in vivo models that could help … …American Journal of Immunology, Vol. 9, Issue 4 · 6 Nov 2013 · 10,982 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation of Anti-Phosphatidylcholine Antibodies with Acute Myocardial Infarction: A Comparative StudyAbdolreza Sotoodeh Jahromi, Mohammad Shojaei, Mohammad Reza Farjam, Abdolhossien MadaniMany factors play a role in Acute Myocardial Infarction (AMI). One those anti-Phospholipid (aPL) antibodies, that may act in the induction of immunological response leading to the development of AMI. Anti-Phosphatidylcholines (PC) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study of anti-PC antibody in AMI might shed light on etiologic … …American Journal of Immunology, Vol. 9, Issue 4 · 28 Oct 2013 · 7,126 accessesView PDFCite
Research ArticleOpen accessIn the abstractTHE PRESENCE OF ANTI-PHOSPHATIDYLETHANOLAMINE ANTIBODIES IN ACUTE MYOCARDIAL INFARCTIONAbdolreza Sotoodeh Jahromi, Mohammad Shojaei, Mohammad Reza Farjam, Abdolhossien MadaniAcute Myocardial Infarction (AMI) is a clinical manifestation of coronary atherothrombosis and is the important causes of death. Many factors play a role in AMI. Anti-Phospholipid (aPL) antibodies may act in the induction of immunological response leading to the development of AMI. Anti-Phosphatidylethanolamine (aPEA) antibody has been detected in various autoimmune diseases and anti-phospholipid antibody syndrome. The study of aPEA … …OnLine Journal of Biological Sciences, Vol. 13, Issue 4 · 21 Oct 2013 · 7,046 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Phosphatidylserine Antibodies in Acute Myocardial InfarctionAbdolreza Sotoodeh Jahromi, Mohammad Shojaei, Mohammad Reza Farjam, Abdolhossien MadaniAcute Myocardial Infarction (AMI) is the combined result of environmental factors and personal predispositions. Many factors play a role in AMI including anti-Phospholipid (aPL) antibodies, that may act in the induction of immunological response leading to the development of AMI. Anti-Phosphatidylserine (PS) antibody is detected in various diseases like rheumatoid arthritis, systemic lupus erythematosus and anti-phospholipid antibody syndrome. The study … …American Journal of Immunology, Vol. 9, Issue 4 · 21 Sep 2013 · 6,963 accessesView PDFCite
Research ArticleOpen accessIn the abstractDIFFERENT CLINICAL AND ANGIOGRAPHIC FINDING IN A SET OF IRANIAN IDENTICAL TWIN: A CASE REPORTMohammad Shojaie, Mohammad Yasin Karami, Mahdi Karimyar Jahromi et al.Both genetic and environmental causes are involved in developing of Coronary Artery Disease (CAD), but there is a notable controversy about the environmental and genetic factors that play a role in the pathogenesis of CAD. The value of each individual risk factor on CAD and the incidence of coronary artery disease in identical twins are indefinite. To find out genetic … …OnLine Journal of Biological Sciences, Vol. 13, Issue 3 · 16 Sep 2013 · 7,181 accessesView PDFCite
Research ArticleOpen accessIn the abstractElevated Th17 and IL-23 in Hypertensive Patients with Acutly Increased Blood PressureJunxian Wang, Jianying Chen, Can Chen et al.Problem statement: Many severe cardiovascular complications such as stroke and heart attack can result from acutely increased blood pressure in patients with hypertension. The underlying mechanisms remain unclear despite of extensive study. To characterize the inflammatory mechanisms in hypertensive patients with acute blood pressure increase, we tested circulating Th17 levels, IL-23R expression and plasma levels of IL-17 and IL-23 in … …American Journal of Immunology, Vol. 8, Issue 2 · 21 May 2012 · 7,911 accessesView PDFCite