72 results for “Cell to Cell Interaction”

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Research ArticleOpen accessIn the abstractBiomarkers of Oxidative DNA Damage and Soluble Fas/Fas Ligand in Type 2 Diabetic PatientsMohamed H. Mahfouz, Ibrahim A. Emara, Ghada A. OmarProblem statement: Involvement of oxidative stress in the pathogenesis of diabetic complications has been proposed. 8-hydroxy-2'-deoxyguanosine (8-OHdG) has been reported to serve as a new sensitive biomarker of the oxidative DNA damage in vivo. Apoptosis via Fas/Fas Ligand (FasL) interactions has been proposed to be a major T-cell-mediated effector mechanism in autoimmune diabetes. This study was undertaken to investigate whether … …American Journal of Applied Sciences, Vol. 9, Issue 4 · 3 Feb 2012 · 7,106 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Widely Used Diagnostics "DNA Microarray"-A ReviewR. Manoj KumarProblem statement: DNA microarray technique is one of the latest advances in the field of molecular biology and medicine. It is a multiplex technique used in combination of bioinformatics and statistical data analysis. Since, 1995, the technique offers the possibility of conducting tens or hundreds of thousands of simultaneous hybridizations. Approach: This increased experimental efficiency permits high throughput and whole … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 7,787 accessesView PDF Cite

Research ArticleOpen accessIn the abstractIntrinsically Unstructured Proteins: Potential Targets for Drug DiscoveryPathan Salma, Chintan Chhatbar, Sriram SeshadriProblem statement: The function of a protein is dependent on its three-dimensional structure. However, numerous proteins lacking intrinsic globular 3D structure under physiological conditions had been recognized. These proteins are frequently involved in some of the most critical cellular control mechanisms and it appears that their rapid turnover, aided by their unstructured nature in the unbound state, provides a level … …American Journal of Infectious Diseases, Vol. 5, Issue 2 · 30 Jun 2009 · 7,578 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPharmacophore Pattern Identification of Tachykinin Receptor Selective Peptide Agonists: Implications in Receptor SelectivityAnjali Dike, Indu R. Chandrashekaran, Anil K. Mantha et al.The mammalian tachykinin (TK) peptides and their three Neurokinin (NK1, NK2 and NK3) receptors represent an effector system with wide-ranging actions on neuronal, airway smooth muscle, mucosal, endothelial, immune, inflammatory and remodeling cell function. Recent clinical and preclinical data suggests the pathophysiological role of TKs in various diseases including asthma, emesis and depression. The TK-NK receptor interactions and overlapping functions … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 6,691 accessesView PDF Cite

Research ArticleOpen accessIn the abstractPrediction of a Putative Functional Region in the Human Bax Protein by Computational AnalysisMaría Sánchez-Aguilar, Laurence A. Marchat, Absalom ZamoranoStructural domains are relevant elements for interactions between Bcl-2 family members to regulate apoptosis and cell survival. Although BH1-BH4 domains can be identified by their sequence and selective occurrence in Bcl-2-family members, structural regions have not been entirely determined yet. The functional residues of Bax, the most representative pro-apoptotic protein of the human Bcl-2 family, remain almost unknown. Here, we … …American Journal of Infectious Diseases, Vol. 3, Issue 2 · 30 Jun 2007 · 7,230 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordStudies on Metal Microbe Interaction of Three Bacterial Isolates From East Calcutta WetlandV. K. Adarsh, Madhusmita Mishra, Sanhita Chowdhury et al.The present paper put forth the isolation and complete characterization of three bacterial isolates from different sites of East Calcutta Wetland (ECW). These isolates show tolerance to heavy metals like Ag, Al, Cu, Cr, Co, Ni, Pb and were found to be efficient metal accumulators as evident from Energy Dispersive X Ray Fluorescence (EDXRF) analysis and Transmission Electron Microscopy (TEM). … …OnLine Journal of Biological Sciences, Vol. 7, Issue 2 · 31 Dec 2007 · 9,423 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordUltrastructural Morphology of the Muscle System Organization in the Trematode Typhlocoelium cucumerinumIrina Yurievna Chidunchi, Ainagul Balgauovna Kaliyeva, Natalya Petrovna Korogod et al.Trematodes, also known as flatworms, are a diverse group of parasitic organisms that live in a variety of ecosystems, from freshwater to marine habitats. Their complex life cycle often involves intermediate and definitive hosts and multiple developmental stages. Trematodes have unique morphological features that allow them to adapt, move and parasitize within host tissues and organs. The parasitic lifestyle of … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 1 Jun 2024 · 5,112 accessesView PDF Cite

Review ArticleOpen accessAll words, across the recordRole of Cytokines and Transcription Factors in Periodontitis: A Review of Cellular and Molecular MechanismsAnne Carolina Eleutério Leite, Valéria Martins de Araújo Carneiro, Júlia Faria Nunes et al.Periodontal Diseases (PD) are characterized by pathological manifestation of host immune response to bacterial infection at the tooth/gingival interface. Evidences points periodontitis as a risk factor for pathological systemic conditions, such as, cardiovascular diseases and diabetes. The identification of host factors that determine their susceptibility to immune subversion can provide useful information in the pathogenesis of periodontitis. Protective acute inflammatory … …American Journal of Immunology, Vol. 11, Issue 4 · 9 Dec 2015 · 7,807 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordHeritability of Qualitative Traits in Forage Pea (Pisum Sativum L.)Valentin Kosev, Yordanka NaydenovaIn breeding process of forage pea (Pisum sativum L.) inter variety crosses between two Bulgarian: Pleven 4 (spring form) and Pleven 10 (winter form) and two Russian: Rosacrono (spring form) and Shtambovyi (winter form) varieties are effectuated in field crop experiment during 2011-2013 on the Second experimental field of the IFC, Pleven, Bulgaria. Populations of P1, P2, F2 and F1 … …OnLine Journal of Biological Sciences, Vol. 15, Issue 4 · 10 Nov 2015 · 7,333 accessesView PDF Cite

Research ArticleOpen accessAll words, across the recordDrug-Protein Interactions for Clinical Research by Nucleic Acid Programmable Protein Arrays-Quartz Crystal Microbalance with Dissipation Factor Monitoring Nanoconductometric AssayClaudio Nicolini, Rosanna Spera, Nicola Luigi Bragazzi, Eugenia PechkovaConductometric monitoring of drug-gene and drug-protein interactions is of fundamental importance in the field of molecular pharmacology. Here, we present our main findings and characterizations of an important antiblastic used in neuro-oncology (Temozolomide), interacting with selected proteins that represent predictive biomarkers of the rate survival of the patients, of the outcome of chemotherapy and resistance to drug itself (namely, BRIP1 … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 3 · 17 Nov 2014 · 8,506 accessesView PDF Cite