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Research ArticleOpen accessEvery word in the titleZinc Deficiency and Associated T-Cell Dysfunctioning among Human Immunodeficiency Virus SeropositivesM. Andrew Pradeep, M. Thiruvalluvan, V. Nalini, J. Stella MaryProblem statement: All the nutrients in the diet play a crucial role in maintaining an optimal immune response. In both, deficient and excessive intake of nutrients can have negative consequence on the immune status and susceptibility to a variety of pathogens. Zinc is an essential micronutrient for human growth development and immune function. It plays a vital role in structure … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 8,041 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Effect of Phyllanthus taxodiifolius Beille Extracts and its Triterpenoids Studying on Cellular Energetic Stage of Cancer CellsPatiwat Sakkrom, Wilart Pompimon, Puttinan Meepowpan et al.Problem statement: The Multidrug Resistance phenomenon (MDR) is the cause of unsuccessful in cancer chemotherapy. The tradition plant is the population used as the alternative medicine in cancer therapy. Due to, P. taxodiifolius is medicinal Thai plant which is used as diuretic drug which has never been explored as the anticancer activities. Approach: Air-dried powder of P. taxodiifolius leaves and … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 8,753 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAntiproliferative Effects of Alkaloids Isolated from the Tuber of Stephania venosa via the Induction of Cell Cycle Arrest in Mammalian Cancer Cell LinesSirinapa Nantapap, Chatchanok Loetchutinat, Puttinan Meepowpan et al.Problem statement: S. venosa (Menispermaceae) is used in traditional medicine. The constituents of S. venosa belonging to showed remarkable cytotoxic activity. According to previous research, S. venosa contains several alkaloids, such as protoberberine stephanine cyclanoline and N-methylstepholidine, kamaline, (+)-N-carboxamidostepharine, (-)-O-methylstepharinosine, (-)-stepharinosine, aporphine (-)-O-acethylsukhodiamine and oxostephanosine. The chemical and biological investigations of this plant are interesting to bioassay-guided fractionation, particularly Antiproliferative … …American Journal of Applied Sciences, Vol. 7, Issue 8 · 31 Aug 2010 · 8,794 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAn in vitro Assessment on the Efficacy of Clay-Based Formulated Cells of Pseudomonas Isolate UTAR EPA2 for Petrol DegradationA. S.Y. Ting, M. T. Fang, C. S. TeeProblem statement: Application of free-cell forms is usually impractical to achieve satisfactory bioremediative effect because the microbes are encumbered by the biotic and abiotic stresses from the environment. Approach: In this study, a hydrocarbon-degrading bacterium (Pseudomonas isolate UTAR EPA2) was formulated with various combinations of formulative materials, comprising of clay-based carrier materials such as Bentonite (B) and Kaolin (K), enrichment … …American Journal of Applied Sciences, Vol. 7, Issue 2 · 28 Aug 2010 · 7,653 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleTransforming Growth Factor-β: An Indirect Inducer of Th17 Cell Differentiation both in Human and Murine SystemJ. SchumannSince their first description only some years ago Th17 cells have become of vital importance in immunological research. However, the role of TGF-β in Th17 cell development is still a matter of controversial discussion. Predicted to have a key function in Th17 cell differentiation in the mouse TGF-β was shown to inhibit IL-17 production of human CD4+ T cells. Moreover, … …American Journal of Immunology, Vol. 6, Issue 2 · 30 Jun 2010 · 7,577 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleQuantum Stem Cell in the Infinity Loop: A New Concept for Our Understanding of the Normal State and CancerKambiz AfrasiabiProblem statement: The scientific community is in need of more rigorous understanding of the mechanism of initiation of mitosis. The complete understanding of the initiation sequence may allow knowledge of the normal and disease states, including cancer. This understanding and knowledge would open the way for developing curative treatment of cancer. This article proposes a mechanism of initiation of mitosis … …OnLine Journal of Biological Sciences, Vol. 10, Issue 2 · 17 Mar 2010 · 8,968 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing CellsCharles Ansah, Nigel J. GooderhamProblem statement: Cryptolepine, the antimalarial plant alkaloid is cytotoxic to mammalian cells, but there is rather little understanding of the possible mechanisms involved in the cell-kill action of cryptolepine. Approach: We examined mammalian cells exposed to cryptolepine (0.5-5.0 μM) for effects on the cell cycle and associated alterations in the levels of major regulatory proteins using immunoblotting and flow cytometry. … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 7,400 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleFabrication of Single Layer SiO2 and Si3N4 as Antireflection Coating on Silicon Solar Cell Using Silvaco SoftwareA. Lennie, H. Abdullah, S. Shaari, K. SopianThe main objectives was to investigate and enhance the short circuit current density, Jsc and also to improve the efficiency of silicon solar cell by fabricating a layer of silicon dioxide (SiO2) and silicon nitride (Si3N4) coatings on silicon solar cell. This fabrication carried out on high temperature during annealing process from 800-1050°C and variable thickness of antireflection coating (ARC) … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 7,679 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAnticancer Activities of Styrylpyrone from the Leaves and Twigs of Goniothalamus maewongensis via Cell Cycle ArrestPradit Pradupsri, Chatchanok Loetchutinat, Narong Nuntasaen et al.Problem statement: Goniothalamus maewongensis is one of three new species which are found in Thailand recently. The genus goniothalamus is not only well known for the rich of styrylpyrones but also famous for the potential of biological activities, especially the cytotoxic activity against a number of human cancer cell lines. The phytochemical and biological investigations of this plant are interesting … …American Journal of Applied Sciences, Vol. 6, Issue 12 · 31 Dec 2009 · 8,195 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIndications of Potential Toxic/Mutagenic Effects of World Trade Center Dust on Human Lung Cell CulturesConstantino G. Lambroussis, Barbara D. Soares, Sergio Perez et al.Problem statement: Respiratory complications have been linked with exposure to dust particulates after the tragedy of September 11th, 2001 at the World Trade Center (WTC) site. Approach: The purpose of these experiments was to investigate the extent of cellular damage resulting from WTC dust exposure. Results: This research project was conducted with human lung fibroblast cells exposed to WTC dust. … …OnLine Journal of Biological Sciences, Vol. 9, Issue 3 · 30 Sep 2009 · 7,396 accessesView PDFCite