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Research ArticleOpen accessEvery word in the titleAntidiabetic and Antioxidant Potential of Vernonia amygdalina Leaf Extract in Alloxan-Induced Sprague-Dawley RatsFatmawaty Yazid, Nina Bonita Hasanah, Rosmalena et al.The treatment of diabetes mellitus using drug medications have side effects such as weight gain, hypoglycemia, the risk of cardiovascular or all-cause mortality. These limitations have become one reason to use complementary therapy from plant extract, such as Vernonia amygdalina as an antidiabetes. This research aimed to investigate the effect of V. amygdalina leaf extracts as antidiabetic and antioxidant agents … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 23 Nov 2020 · 8,649 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSafety Assessment of Indigenous Probiotic Strain Lactobacillus plantarum Mut-7 Using Sprague Dawley Rats as a ModelAtika Yahdiyani Ikhsani, Emma Riftyan, Rosa Amalia Safitri et al.Lactobacillus plantarum Mut-7 is a probiotic candidate isolated from gatot, traditional fermented cassava from Java, Indonesia. This study aimed to evaluate safety aspects of high dose consumption of L. plantarum Mut-7 (1011 CFU/ml/day) on Sprague Dawley rats for 21 days. Twenty four female rats were randomly divided into 4 groups; initial condition group (P.0), control group (P.1), skim milk group … …American Journal of Pharmacology and Toxicology, Vol. 15, Issue 1 · 30 Apr 2020 · 8,690 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleCopper (I)-Nicotinate Promotes Gene Expression of CYPs that Produce M1 and Q1 in Aflatoxicosed RatsMohammed Salah, Laila Mostafa, Tahia H. Saleem et al.Aflatoxin-contaminated food poses a serious risk to both human and animal health. Copper (1)-nicotinate (Cu+-nicotinate) complex potentiated the prophylactic effect against chronic aflatoxicosis in the experimental animals through the synthesis of less toxic metabolites M1 and Q1 which are easily excreted in urine. To investigate the action of the safety Cu+-nicotinate complex on gene expression of Cytochrome 450 (CYP450) system, … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 28 Jan 2020 · 8,152 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleSafety Assessment of Indigenous Probiotic Strain Lactobacillus plantarum Dad-13 Isolated from Dadih Using Sprague Dawley Rats as a ModelEndang S Rahayu, Ilzamha H Rusdan, Armita Athennia et al.Lactobacillus plantarum Dad-13 is a probiotic candidate from dadih, a traditional fermented buffalo milk from West Sumatera, Indonesia. This study aimed to evaluate safety aspects of L. plantarum Dad-13 in high dose consumption on Sprague Dawley rats. Two treatment groups were fed with 1011 CFU/mL/day of L. plantarum Dad-13 for 14 and 28 days respectively. Two placebo groups were fed … …American Journal of Pharmacology and Toxicology, Vol. 14, Issue 1 · 12 Nov 2019 · 10,134 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleImmunological Response of Albino Rats Immunized with UV-Killed Candida albicansAhmad Ibrahim, Yahaya Abdullahi Umar, Mohammed Shehu BusuThe treatments of systemic candidiasis in humans with the current antifungal drugs of choice such as azole derivatives and amphotericin B have raised issues of toxicity and resistance among others. The immunogenic property of killed C. albicans was explored to evoke immunological response in the possible prevention of candidemia. Rats were immunized after acclimatization on two occasions with 106 cells/ml … …American Journal of Biochemistry and Biotechnology, Vol. 15, Issue 3 · 26 Jul 2019 · 7,714 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleEffect of Curcumin and Physical Training on the Brain and Motor Performance of Rats with Cerebral IschemiaKarine Sthéfany Serpa Amaral Dias, Jonas Augusto Ramos, Bruno Mattiello Gomes et al.Brain ischemia is the second most deadly disease in the world and it has already been proven that mild and moderate physical exercises minimize the deleterious effects of this disease on the brain. Curcumin has also been considered a neuroprotective substance. Therefore, the goal of this study was to evaluate the effects of high-resistance training and curcumin on the brain … …Neuroscience International, Vol. 10, Issue 1 · 25 Apr 2019 · 7,765 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAntioxidant Properties and Dose-Dependent Effects of Monkey Fruits (Artocarpus lakoocha) against Paracetamol-Induced Hepato-Renal Toxicity in RatsMd. Yousuf Ali, Md. Reaz Morshed, Md. Sakib Hossen et al.In this study, the antioxidant potentials and protective effect of ethanolic extract of monkey fruits (Artocarpus lakoocha) (AL) was investigated against paracetamol-induced toxicity in rats. AL which contains high concentration of polyphenols, flavonoids, tannins and protein, exhibited high radical scavenging activity and ferric reducing antioxidant power. Administration of paracetamol (500 mg/kg) for seven consecutive days caused severe oxidative stress in … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 26 Nov 2018 · 8,337 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleThe Influence of Garcinia kola Seed on Sexual Behavior and Testis Physiology in Wistar RatsJonah Sydney Aprioku, Victor Nwachukwu, Blessing Ukamaka Okeke et al.Garcina kola seed is believed by some to enhance male sexual performance but existing scientific data show divergent results. In this study, the sexual and reproductive influence of ethanol (70%) seed extract of G. kola was evaluated in Wistar rats. Adult male rats were gavaged with 0, 50, 100, 200 or 300 mg kg-1 day-1 of extract for 30 days … …American Journal of Pharmacology and Toxicology, Vol. 13, Issue 1 · 25 Apr 2018 · 13,804 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleModulatory Effects of Bryophyllum Pinnatum Leaves Extract on Peroxidation Indices of CCl4 Induced-Hepatotoxicity in Wistar Albino RatsChioma Assumpta Anosike, Sophia Uyo Mokwunye, Victor Eshu Okpashi, Obiorah AbonyiThis research investigated the modulatory effect of methanol extract of Bryophyllum pinnatum leaves on peroxidation indices of CCl4-induced hepatotoxicity. Thirty rats of average weight 150g divided into six groups of 5 rats each were used for the study. Group one (control) received water and paraffin for ten days. Group two (treatment control) received water only, group 3 (standard control), received … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 3 · 17 Dec 2017 · 7,448 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAssessment of Type 2 Anti-Diabetes on Bound Flavonoids of Barringtonia racemosa (L.) Spreng. Kernel in Glucose-Induced Diabetic RatsMusri Musman, Emelda Audina, Fazlia Inda Rahmayani Ratu et al.A study of type 2 anti-diabetes on bound flavonoids fraction from the kernel of Barringtonia racemosa (L.) Spreng. in glucose-induced diabetic rats was performed. This learning aimed to gather scientific information about the possibility to utilize kernel of B. racemosa as a raw material of antidiabetic drug. The antioxidant property of the bound flavonoids was determined by the DPPH scavenging … …American Journal of Pharmacology and Toxicology, Vol. 12, Issue 3 · 16 Dec 2017 · 8,040 accessesView PDFCite