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75 results for “pathophysiology”
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Review ArticleOpen accessIn the abstractPotential Effects of Adropin in Subarachnoid HemorrhageZahra Hasanpour Segherlou, Mohammad Reza Hosseini Siyanaki, Brandon Lucke-WoldSubarachnoid Hemorrhage (SAH) typically, occurs in patients over 55 years of age and can cause a significant loss of productivity. SAH also has a high mortality rate and those who survive often suffer from early and secondary brain injuries that can result from the condition. By gaining a better understanding of the pathophysiology of SAH, it may be possible to … …Neuroscience International, Vol. 13, Issue 1 · 21 Jul 2023 · 9,246 accessesView PDFCite
Research ArticleOpen accessIn the abstractRelease of Endogenous Chondroitin Sulfate and Heparin as Consequence of Dysregulated Proteolysis in COVID-19Marco RuggieroInfection by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2), the pathogen responsible for COVID-19, is associated with immune-mediated responses that lead to dysregulated activation of proteolytic enzymes; these contribute to damage to the endothelium, thrombosis, hypercoagulability and other hematologic complications that include thrombotic thrombocytopenia, a complication of severe COVID-19 as well as a potentially fatal adverse effect of COVID-19 vaccination. … …American Journal of Immunology, Vol. 17, Issue 1 · 29 Dec 2021 · 7,691 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssessment of Therapeutic Effects of Platelet-Rich Plasma in Knee Osteoarthritis: Possible Role of Inflammatory CytokinesMohammed H. Hassan, Sawsan Abuhamdah et al.Osteoarthritis (OA) is a multifactorial disease that commonly affects the knee. Tumor Necrosis Factor-α (TNF-α) regulates inflammation during OA. Macrophage Migration Inhibitory Factor (MIF) may be involved in the pathophysiology of arthritis. Platelet-Rich Plasma (PRP) may reduce pain associated with OA. The present study assessed the possible therapeutic effects of PRP in patients with OA of the knee with varying … …American Journal of Biochemistry and Biotechnology, Vol. 17, Issue 2 · 15 Jun 2021 · 6,991 accessesView PDFCite
Research ArticleOpen accessIn the abstractEndothelial Dysfunction and Insulin Resistance as Pathophysiologic Mechanisms in a Rat Model of PreeclampsiaAyman Z. Elsamanoudy, Amr M. AbbasProblem statement: To assess the plasma concentrations and placental gene expression of soluble fms like tyrosine kinase (sFlt-1), Vascular Endothelial Growth Factor (VEGF), visfatin and Tumour Necrosis Factor α (TNFα) in a rat model of preeclampsia, induced by chronic Reduction of Uterine Perfusion Pressure (RUPP) and to investigate the involvement of Insulin Resistance (IR) in the pathophysiology of preeclampsia and … …American Journal of Biochemistry and Biotechnology, Vol. 6, Issue 3 · 30 Sep 2010 · 7,509 accessesView PDFCite
Research ArticleOpen accessIn the abstractMitochondrial Energy-Deficient Endophenotype in AutismJ. Jay Gargus, Faiqa ImtiazWhile evidence points to a multigenic etiology of most autism, the pathophysiology of the disorder has yet to be defined and the underlying genes and biochemical pathways they subserve remain unknown. Autism is considered to be influenced by a combination of various genetic, environmental and immunological factors; more recently, evidence has suggested that increased vulnerability to oxidative stress may be … …American Journal of Biochemistry and Biotechnology, Vol. 4, Issue 2 · 30 Jun 2008 · 11,518 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Novel Mutations of AMH Gene in Iraqi Women with Premature Ovarian FailureFarah Amer Abed, Raya E. Maroof, Ulfat Mohammed Ali Al-NakkashAn over all of thirty females experiencing idiopathic POF and thirty controls have been studied and among them only six patients and four control were sent to sequence. The AMH gene fragments AMH1, AMH2 and AMH5 generates 530 bp, 288 bp and 1080 bp respectively were amplified. Fragments were sequenced and the results show six out of eight observed SNPs … …OnLine Journal of Biological Sciences, Vol. 18, Issue 4 · 11 Dec 2018 · 7,254 accessesView PDFCite
InvestigationOpen accessIn the abstractChronic Lyme Disease: A Working Case DefinitionRaphael B. Stricker, Melissa C. FeslerAlthough Lyme disease is the most common tickborne illness in the USA and Eurasia, the pathophysiology and clinical course of chronic Lyme disease (CLD) have not been formally defined. The purpose of this paper is to present a working case definition of CLD based on analysis of more than 700 peer-reviewed publications. According to this definition, CLD is a multisystem … …American Journal of Infectious Diseases, Vol. 14, Issue 1 · 16 Apr 2018 · 21,297 accessesView PDFCite
Review ArticleOpen accessIn the abstractRoles of DLK1 in Liver Development and OncogenesisIsabella Kurnia Liem, Sibiri Indriyani, Msy Rulan Adnindya, Ahmad Azmi NasutionHepato Cellular Carcinoma (HCC) has an increased mortality rate in the last decade. Protein expression in HCC has similarities to the liver cells during the development process. One of the proteins expressions is Delta-Like 1 homolog (DLK1) that was found during liver development and oncogenesis. This permits the opportunity to study pathophysiology and signaling pathway of DLK1 and to find … …OnLine Journal of Biological Sciences, Vol. 17, Issue 4 · 23 Oct 2017 · 8,056 accessesView PDFCite
EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,740 accessesView PDFCite
Research ArticleOpen accessIn the abstractCALCITONIN GENE-RELATED PEPTIDE IN SERUM AFTER SPONTANEOUS SUBARACHNOID HEMORRHAGEKarl-Michael Schebesch, Elisabeth Bruendl Andreas Hochreiter, Judith Scheitzach et al.Endogenous Calcitonin Gene-Related Peptide (CGRP) stored in perivascular nerve fibers around the cerebral arteries mediates vasodilation and regulates cerebral blood flow under physiological conditions. Increased levels of CGRP have been continually reported in patients with migraine, but the role of CGRP in the pathophysiology of Subarachnoid Hemorrhage (SAH) has not yet been sufficiently evaluated. Over 10 days, serum was prospectively … …Neuroscience International, Vol. 5, Issue 1 · 28 Jun 2014 · 7,594 accessesView PDFCite