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Research ArticleOpen accessIn the abstractBiocompatibility of Orthodontic Resins: In vitro Evaluation of Monomer Leaching and Cytotoxic EffectsRoberto Uomo, Gianrico Spagnuolo, Giuseppina Nocca et al.The aim of this study was to investigate the effect of orthodontic resins on cell survival and to evaluate monomer leaching both before and after resin polymerization. Materials and methods: 3T3 mouse fibroblasts were exposed to three cured and uncured orthodontic resins. Cellular viability was assessed by Alamar Blue assay after 24, 48 and 72 h. High Performance Liquid Chromatography … …Current Research in Dentistry, Vol. 8, Issue 1 · 7 Jul 2017 · 16,333 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,281 accessesView PDFCite
Research ArticleOpen accessIn the abstractCpG Oligodeoxynucleotides Debate the Damaging Action of Cisplatin on Immune Cell DNA: A PCR Array Application on Repair Genes ExpressionNaglaa Fathy Alhusseini, Amal Abo El-Fadl, Shabaan Hemada et al.Synthetic Oligodeoxynucleotides (ODN) expressing CpG motifs (CpG-ODN) mimic the immunostimulatory activity of bacterial DNA and are commonly used to activate Toll Like Receptor 9 (TLR9) for therapeutic applications. CpG-ODN can counteract the activity of DNA-damaging chemotherapy and radiation therapy on immune cell and enhance immunity in preclinical mouse models. We hypothesized that these actions of CpG-ODN on immune cells are … …American Journal of Biochemistry and Biotechnology, Vol. 12, Issue 3 · 27 Jul 2016 · 7,625 accessesView PDFCite
Research ArticleOpen accessIn the abstractModulation of IFN-γ, IL-4 and IL-17 Cytokines is Related to Parasitemia Control in Mice Infected by Trypanosoma cruzi and Treated with BiotherapyFabiana Nabarro Ferraz, Franciele Karina da Veiga, Denise Lessa Aleixo et al.The study of biotherapies as an intervention in experimental models of infection is a possible means to understand the effects of these highly diluted medications. The present study evaluated the immunological and parasitological effects of biotherapies that were prepared from mouse serum that was uninfected (sarcode: BSNI13cH group) and chronically infected with the Y strain of T. cruzi (nosode: BSI13cH … …OnLine Journal of Biological Sciences, Vol. 15, Issue 4 · 30 Oct 2015 · 7,357 accessesView PDFCite
EditorialOpen accessIn the abstractCRISPR-CAS SYSTEM: A FEASIBLE SOLUTION FOR GETTING RID OF PERSISTENT VIRAL INFECTION?Zhaohua ZhongMany viruses, including DNA and RNA viruses, can persistently replicate in the infected cells and cause a prolonged damage. Herpes viruses can be latent in its host cells. Human Immunodeficiency Virus (HIV) reversely transcripts its RNA genome to DNA and integrates to the host’s chromosome. Hepatitis B Virus (HBV) and Human Papilloma Virus (HPV) persistently stay in the host cells … …Current Research in Virology, Vol. 3, Issue 1 · 10 Nov 2014 · 12,614 accessesView PDFCite
Research ArticleOpen accessIn the abstractPRODUCTION AND CHARACTERIZATION OF MONOCLONAL AND POLYCLONAL ANTIBODY AGAINST RECOMBINANT OUTER MEMBRANE PROTEINMahdi Fasihi-Ramandi, Amir Nedjad-Moghaddam, Fatemeh Arabsalmany et al.There are many studies related to immunological and molecular methods for diagnosis of Vibrio cholera (V. cholerae). However, most assays dependent on enrichment of culture of bacteria, which need more time and involves the use of costly equipment and reagents. In this study Balb/c mice were immunized with recombinant Outer Membrane Protein (rOMPw) of vibrio cholerae and splenocytes of hyper … …American Journal of Immunology, Vol. 10, Issue 1 · 26 Apr 2014 · 7,439 accessesView PDFCite
Research ArticleOpen accessIn the abstractATRA AS A POTENTIAL ANTIMETASTATIC AGENT IN COLORECTAL ADENOCARCINOMARobert Edwards, Kambiz Afrasiabi, Kehui WangThe family of Retinoic acid compounds have long been the subject of intense study and interest as chemo prophylactic agents. This dates back to their therapeutic effect in leukoplakia Where ATRA was shown to lead to the reversal of premalignant lesions and Subsequent reports on their use in metastatic colorectal adenocarcinoma and a vast array of other malignant disorders as … …OnLine Journal of Biological Sciences, Vol. 14, Issue 2 · 26 Mar 2014 · 7,344 accessesView PDFCite
Research ArticleOpen accessIn the abstractEXPOSURE TO SWINE HOUSING DUST MODULATES MACROPHAGE MORPHOLOGY AND FUNCTIONRuth J. Pender, Radiah C. Minor, Steven L. Hurley et al.Swine Confinement Facility (SCF) dust consists of a complex mixture of feed grain particles, bacterial components, organic particulates and gases. When these particles are inhaled they deposit along the respiratory tract and mediate respiratory symptoms and disease in swine farmers and facility workers. Macrophages ingest and eliminate microbes and debris under chronic conditions; however, the role of macrophages in agricultural-related … …American Journal of Immunology, Vol. 10, Issue 1 · 25 Mar 2014 · 7,606 accessesView PDFCite
Research ArticleOpen accessIn the abstractCYCLIC CHOLECYSTOKININ ANALOGUES EXHIBIT HIGH BLOOD STABILITY AND BINDING AFFINITY WITH CHOLECYSTOKININ RECEPTOREun-Ha Joh, Jae Cheong Lim, Jin Joo Kim et al.Recently, incidence of Cholecystokinin (CCK) receptor is recognized as a factor that determines the aggressive phenotype of pancreatic cancer. In this study, a novel Cholecystokinin (CCK) analogues; DOTA-Nle-cyclo (Glu-Trp-Met-Asp-Phe-Lys-NH2) (DOTA-cCCK) and DOTA-Nle-cyclo (Glu-Trp-Nle-Asp-Phe-Lys-NH2) (DOTA-[Nle]-cCCK) were synthesized and radiolabeled and the targeting abilities on the CCK receptor were evaluated for new CCK receptor targeting agents searching. Peptides were prepared through a … …OnLine Journal of Biological Sciences, Vol. 14, Issue 1 · 2 Jan 2014 · 7,556 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Green Tea on Hepatic Cells Under the Influence of Inflammatory Conditions: In Vitro StudyIbrahim G. Saleh, Zulfiqar Ali, Farid M. Hamada et al.The concern about safety of consumption of Green Tea (GT) supplements has become a scope of many studies. We and others have described earlier the effect of the administration of GT and its polyphenols on liver in a mouse model. In this study we aimed to investigate the effect of GT on HepG2 cells. HepG2 cells were treated with different … …American Journal of Pharmacology and Toxicology, Vol. 8, Issue 4 · 3 Dec 2013 · 7,314 accessesView PDFCite