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Research ArticleOpen accessEvery word in the titleComparative Permeation Studies between Scale Region of Shed Snake Skin and Human Skin In vitroAroonsri Priprem, Chidchanok Khamlert, Thaned Pongjanyakul et al.Scales of shed king cobra (Ophiophagus hannah) skin from the dorsal portions, (SSS) and human breast epidermis (HE) were used as barrier membranes for comparison in an in vitro drug permeation study of nine active compounds (MW range 150-300 g mol-1, pKa 3-10). Each compound, saturated in a donor solution at pH 4.0 or 5.6, permeated through the barrier membrane, … …American Journal of Agricultural and Biological Sciences, Vol. 3, Issue 1 · 31 Mar 2008 · 8,413 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHuman Resource Development Strategies: The Malaysian ScenarioHaslinda Abdullah, Raduan Che Rose, Naresh KumarThe socio-economic development of Malaysia is greatly influenced by human resources activities in both the private and public sectors. But the private sector, particularly the industrial sector is the key player for the country’s economic growth. In acknowledging human resources importance in this sector, the country’s developmental plans developed thrusts that support the development of human resources to become skilled, … …Journal of Social Sciences, Vol. 3, Issue 4 · 31 Dec 2007 · 8,713 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleAn in vitro Permeation of Phyllanthus amarus Extract Through Human and Shed Snake SkinsAroonsri Priprem, S. Radapong, S. Preeprame et al.An in vitro permeation of a hydroalcoholic extract of Phyllanthus amarus (PaE) was investigated using excised human epidermis and shed king cobra skin as the barrier membranes. Donor and receptor compartments of diffusion cells were pH-controlled to simulate the permeation environment of the human skin. The PaE was analyzed by using normal-phase densitometric TLC detected at λ 280 nm and … …American Journal of Agricultural and Biological Sciences, Vol. 2, Issue 3 · 30 Sep 2007 · 7,787 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleRapamycin Inhibits Cystogenesis by Cystic Epithelial Cells Derived from Human Autosomal Dominant Polycystic KidneysGerard Elberg, Teresa V. Lewis, Lijuan Chen, Martin A. TurmanAutosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders and carries a high health burden since it progresses to renal failure in half of the afflicted individuals by the 6th decade of life. Currently, there is no effective treatment to slow the progression of ADPKD. Rapamycin, a drug most commonly used as an immunosuppressive agent … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,101 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHuman Insulin Modulation of Escherichia coli Adherence and ChemotaxisKarolina Klosowska, Balbina J. PlotkinEscherichia coli exhibited increased hydrophobicity and mannose-resistant epithelial cell adherence after growth in the presence of human insulin (2 μU mL-1 or 200 μUmL-1 insulin, respectively) with glucose (100 mg dL-1). Capsule production and hemagglutination were unaffected by insulin and glucose. Chemotactic attraction to glucose as compared to insulin or glucose alone was enhanced by the presence of insulin. Insulin … …American Journal of Infectious Diseases, Vol. 2, Issue 4 · 31 Dec 2006 · 7,104 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleHeroin-Induces Differential Protein Expression by Normal Human Astrocytes (NHA)Jessica L. Reynolds, Supriya D. Mahajan, Donald Sykes, Madhavan P.N. NairHeroin use is postulated to act as a cofactor in the neuropathogenesis of human immunodeficiency virus (HIV-1) infection. Astrocytes, integral components of the CNS, are reported to be susceptible to HIV-1 infection. Upon activation, astrocytes release a number of immunoregulatory products or modulate the expression of a number of proteins that foster the immunopathogenesis of HIV-1 infection. However, the role … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 7,261 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleA 2-Dimensional Model for the Transmission Dynamics of Schistosomiasis in the Human-Snail HostsG. Besigye-BafakiThe modes of transmission of schistosomiasis are considered. The transmission model is developed with an aim of establishing possible endemic equilibria within the community. Analysis of the model reveals that if the recovery rate β of human infectives and the death rate of snails δ are increased and if at the same time the contact rate κ of the human … …American Journal of Applied Sciences, Vol. 3, Issue 5 · 31 May 2006 · 6,506 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleGenetic Complementation Studies of Human Pin1 in Azotobacter vinelandii Revealed that it Requires Amino Terminus of the NifM to Deliver PPIase Effect to the Fe-protein of NitrogenaseKumaraguru Raja, Lakshmi Pulakat, Nara GaviniThe NifM is a peptidyl prolyl cis-trans isomerase and is required for the maturation and activation of the Fe protein of Nitrogenase. Since the carboxyl terminus of NifM is similar to the Human Pin1, we expressed the Human Pin1 in A. vinelandii BG98, a nifM mutant strain containing a kanamycin insertion and found that it could not complement the function … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 1 · 31 Mar 2006 · 6,708 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleIn vitro Activation of Human and Rat Lymphocyte and Macrophage Functions by NorepinephrineRicardo Gomez-Flores, Diana Caballero-Hernandez, Richard J. Weber et al.Norepinephrine (NE) has been associated not only with increasing blood pressure, atherosclerosis, heart disease, and other life threatening conditions, but also with altering immune responses by influencing leukocyte functions. In the present study, we evaluated the in vitro effects of NE on rat thymic lymphocyte and human peripheral blood mononuclear cells (HPBMC) functions. We observed that NE marginally, but significantly … …American Journal of Immunology, Vol. 1, Issue 4 · 31 Dec 2005 · 7,075 accessesView PDFCite
Research ArticleOpen accessEvery word in the titleLarge Scale Production and Characterization of Anti-Human IgG Monoclonal Antibody in Peritoneum of Balb/c MICEB. Baradaran, J. Majidi, Z. M. Hassan, J. AbdolalizadehMonoclonal antibodies are key reagents that are used in biomedical researches, diagnosis of immunodeficiency diseases such as IgG subclasses deficiency and treatment of diseases like infections and cancers. For large scale production of monoclonal antibody, hybridoma cells that produce monoclonal antibody against human IgG were injected into the peritoneum of the Balb/c mice which have previously been primed with 0.5 … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 4 · 31 Dec 2005 · 7,089 accessesView PDFCite