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Research ArticleOpen accessIn the keywordsThe Role of Treg Cells in the Cancer Immunological ResponseZhi-Zhang Yang, Stephen M. AnsellProblem statement: T cell-mediated immunosuppression has been observed for decades without clarification as to which factor was responsible for this observation. The identification of CD4+CD25+ regulatory T (Treg) cells represents a milestone in the filed of immunology and provides an explanation for T-cell-mediated immunosuppression. Although Treg cells were originally identified for their ability to prevent organ-specific autoimmune disease in mice, … …American Journal of Immunology, Vol. 5, Issue 1 · 31 Mar 2009 · 8,524 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCancer may be caused by the Immune ReactionRichmond T. PrehnHormesis-like effects of immunity have been documented during tumor-growth experiments in mice, quantitatively large immune-reactions have inhibited while lesser quantities of the same specific immune-reactants have been stimulatory to the growth of implanted tumors. Likewise, carcinogenesis has been inhibited by a high quantities of immune reactants, but positively stimulated by lower levels of the same reactants. One observation suggests that … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,462 accessesView PDFCite
Research ArticleOpen accessIn the keywordsThe Phenotypically Suppressed Cancer Cell As a Therapeutic TargetKimberly D. Kyker, Jessica E. Thorpe, Satyendra S. Shenoy et al.Bladder cancer recurs in up to 70% of patients judged to be tumor-free after treatment. Like other cancers, delayed appearance of metastases is common. These findings suggest the malignant phenotype can be suppressed, to emerge later. Following up on previous research in our laboratory showing that normal extracellular matrix can suppress the malignant phenotype of bladder cancers, we here demonstrate … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 6,474 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCYCLIC CHOLECYSTOKININ ANALOGUES EXHIBIT HIGH BLOOD STABILITY AND BINDING AFFINITY WITH CHOLECYSTOKININ RECEPTOREun-Ha Joh, Jae Cheong Lim, Jin Joo Kim et al.Recently, incidence of Cholecystokinin (CCK) receptor is recognized as a factor that determines the aggressive phenotype of pancreatic cancer. In this study, a novel Cholecystokinin (CCK) analogues; DOTA-Nle-cyclo (Glu-Trp-Met-Asp-Phe-Lys-NH2) (DOTA-cCCK) and DOTA-Nle-cyclo (Glu-Trp-Nle-Asp-Phe-Lys-NH2) (DOTA-[Nle]-cCCK) were synthesized and radiolabeled and the targeting abilities on the CCK receptor were evaluated for new CCK receptor targeting agents searching. Peptides were prepared through a … …OnLine Journal of Biological Sciences, Vol. 14, Issue 1 · 2 Jan 2014 · 7,559 accessesView PDFCite
Research ArticleOpen accessIn the keywordsFabrication and Testing of a Medical Surgical Instrument Capable of Detecting Simulated Embedded LumpsJavad Dargahi, Siamak Najarian, Reza Ramezanifard, Farhad Tabatabai GhomsheA novel endoscopic grasper is being fabricated and tested. This grasper can be used in detecting lumps or tumors in biological tissues. The detailed fabrication process of the tactile sensor has been discussed. Custom-made sensors were integrated with the jaws of the endoscopic grasper and objects with known tactile features were tested by the designed grasper. Different experiments were performed … …American Journal of Applied Sciences, Vol. 4, Issue 12 · 31 Dec 2007 · 7,002 accessesView PDFCite
Research ArticleOpen accessIn the keywordsAdaptive Data Transformation for Enhanced Clustering Performance in Diagnostic SystemsMohammed Subhi Al-BatahThis paper presents an enhanced approach to the Balanced Iterative Reducing and Clustering using Hierarchies (BIRCH) algorithm, aimed at improving clustering accuracy in medical data, specifically for breast cancer diagnosis. The proposed method introduces a modified data transformation technique to optimize the original BIRCH algorithm. This transformation refines the clustering process, resulting in significant improvements in diagnostic accuracy. The modified … …Journal of Computer Science, Vol. 21, Issue 9 · 17 Oct 2025 · 2,294 accessesView PDFCite
Research ArticleOpen accessIn the keywordsCorrelation of Some Biochemical Parameters between Serum and Saliva of Patients with Breast CancerOmar Atrooz, Huthaifa TarawnehRegular breast cancer laboratory examination of serum is aburden on patients, therefore understanding salivary test methods' featuresand limits is important for diagnosis. The study aims to evaluate thebiochemical parameters in the serum and saliva of breast cancer and controlindividuals. Furthermore, to investigate the correlation between two biofluidlevels in both groups. This cross-sectional study recruited Jordanian femalesincluding 40 breast cancer patients … …OnLine Journal of Biological Sciences, Vol. 25, Issue 2 · 20 May 2025 · 4,493 accessesView PDFCite
Research ArticleOpen accessIn the keywordsImpact of Vitamin B17 Against Growth of Colitis Bearing Mice Induced Variations in Colon Structure, AFP, CEA and PCNA ImmunoreactivityGihan Hosny Abd Elsamie, Sabah Gaber El-Banna, Ehab Tousson et al.Colitis alludes to inflammation of the internal coating of the colon that accompanied clinically through abdominal pains, diarrhea, weight loss, nausea. Current study aimed to study the impact of vitamin B17 against growth of colitis bearing mice induced variations in colon structure, AFP, CEA and PCNA immune reactivity. Forty female Swiss albino mice separated into 4 groups (Control, vitamin B17, … …OnLine Journal of Biological Sciences, Vol. 21, Issue 3 · 23 Aug 2021 · 6,401 accessesView PDFCite
Research ArticleOpen accessIn the keywordsSelective Susceptibility of Human Bladder Transitional Cell Carcinoma T24 Cells towards NBD PeptideSankari Durairajan, Charles Emmanuel Jebaraj Walter, Kalaiselvi Periyandavan et al.Bladder cancer is a recurrent disease that often develops chemoresistance and is on the rise in developing countries. After diagnosis surgery followed by immunotherapy and/or chemo- radiation therapy are the available treatments. These treatments do not provide protection against disease progression or recurrence thus highlighting the need to identify and develop drugs that are capable of inhibiting bladder cancer. T24 … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 2 · 20 Apr 2020 · 7,789 accessesView PDFCite
Research ArticleOpen accessIn the keywordsStudy the Impact of T-helper 1 Cytokine (TNF-α) Polymorphisms on Susceptibility/Resistance to Brucellosis in Makkah RegionAlaa B. Ismael, Adil Mergani, Salama A-H Mostafa, Abdelmoneim M. SalimPolymorphisms in the regulatory regions of cytokine genes may not only increase susceptibility to some infectious diseases but also affect the course and prognosis of the disease. TNF-α is considered an important Th1 cytokines that plays critical roles in control of Brucella infection and in macrophage activation. In this study, we are going to analyze the relationship of two polymorphisms … …American Journal of Infectious Diseases, Vol. 12, Issue 3 · 9 Aug 2016 · 7,120 accessesView PDFCite