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129 results for “Proliferation”
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Research ArticleOpen accessIn the abstractInternalizing Versus Non-internalizing Receptors for Targeting L-Methioninase to Cancer CellsXiao-Ping Zang, Naveen R. Palwai, J. T. Pento, Roger G. HarrisonWe reported previously that L-methioninase targeted to the urokinase receptor of MCF-7 breast cancer cells is significantly more effective in inhibiting cell proliferation and migration than free L-methioninase both in vitro and in vivo. L-methioninase was targeted by linking at its amino terminus to an amino-terminal fragment (ATF) of urokinase. The ATF was selected for targeting because is has previously … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 3 · 30 Sep 2006 · 7,818 accessesView PDFCite
Research ArticleOpen accessIn the abstractDietary supplementation with Cyperus esculentus L (tiger nut) tubers attenuated atherosclerotic lesion in apolipoprotein E knockout mouse associated with inhibition of inflammatory cell responsesMohamed L. Salem, Mohsen Zommara, K. ImaizumiAtherosclerosis is a pathological process, where recruitment of mononuclear cells results in the growth of fibro-fatty plaques. Apolipoprotein E (ApoE) is a legend for the uptake of lipoproteins, and deficiency of ApoE leads to the accumulation of low-density lipoprotein. Utilizing ApoE-/- mouse, which spontaneously develop atherosclerosis on low-fat chow diets, the present study showed that feeding these mice on a … …American Journal of Immunology, Vol. 1, Issue 1 · 31 Mar 2005 · 10,479 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Polysaccharide-Rich Fraction Derived from Oviductus ranae with Antioxidant and Immunomodulatory PotentialsXiaojin Yu, Xinyu Wang, Xinyu Liu et al.Oviductus ranae, an animal-based traditional Chinese medicinal material listed in Chinese Pharmacopeia is widely consumed as tonic, approximately twenty Oviductus ranae-related functional foods have been approved on the market by National Medical Products Administration in China. Proteins are well-defined bioconstituents in Oviductus ranae, little information is availabe on its polysaccharides. In present work, a Polysaccharide-Rich fraction (POR-3) was fractionated from … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 3 · 13 Sep 2020 · 6,627 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Relevance of Bioinformatic Tools in the Study of Polymorphisms of the B4GALNT2 Gene and its Association with CancerEddaikra Atika, Haddouche Hayet, Touil-Boukoffa ChafiaThe human gene B4GALNT2 encodes an enzyme (β1,4-N-acetylgalactosaminyltransferase II) that controls the expression of the blood group Sda carbohydrate’s antigen. This gene is located in position 17q21,32 and consists of 11 exons. The characterization and understanding of genetic variation is a real challenge in human genetics, both for healthy individuals and diseased ones. The in silico study of the B4GALNT2 … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 27 Feb 2020 · 6,773 accessesView PDFCite
Research ArticleOpen accessIn the abstractPatient Data Integration: A Panacea for Effective HealthcareHenry Anayo Okemiri, Alo Uzoma Rita, Achi Ifeany Isaiah et al.A huge challenge in the healthcare domain has remained the spread and proliferation of fragmented information systems and multiplicity of data that accumulate from growing quantities of heterogeneous data of patient. This challenge must be addressed as the whole domain gradually transforms into models of delivery of healthcare that is electronic and patient-centered. The presence of inadequate data integration at … …Journal of Computer Science, Vol. 16, Issue 2 · 22 Feb 2020 · 7,732 accessesView PDFCite
Research ArticleOpen accessIn the abstractIdentification of Long Non-coding RNAs Expressed During Early AdipogenesisRongkun Shen, Rachel A. Soeder, Henry D. Ophardt et al.Long non-coding RNAs (lncRNAs) are transcripts with a length of more than 200 nucleotides that lack protein-coding capacity. LncRNAs play important roles in the regulation of genes during many biological processes, development and disease progression, such as obesity. Obesity is an increasing health concern around the world. Although multiple studies linking lncRNAs and fully differentiated adipocytes have been published, the … …OnLine Journal of Biological Sciences, Vol. 19, Issue 4 · 30 Nov 2019 · 7,830 accessesView PDFCite
EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,662 accessesView PDFCite
Research ArticleOpen accessIn the abstractCytotoxic Activity of Tinospora crispa Crude Extracts (Stem) Against K562 Human Leukemia CellsNormah Awang, Haziratul Iffah Ruzali, Rapidah Mohamad et al.Tinospora crispa (T. crispa) is traditionally used as an herbal medicine for treatment of gout and is an analgesic, anti-inflammatory and antihyperuricemic agent. Cytotoxicity of hexane, dichloromethane, ethanol and aqueous extracts of T. crispa stem against K562 cells was assessed. Crude extracts of T. crispa stem were obtained by sonication and maceration methods. T. crispa stem powder was macerated and … …OnLine Journal of Biological Sciences, Vol. 19, Issue 2 · 11 May 2019 · 7,872 accessesView PDFCite
Research ArticleOpen accessIn the abstractReal-Time Data Capture Model for Accelerated Payment of Small-Scale FarmersNatasha Mwansa, Jackson PhiriMost developing countries especially in Africa face a number of challenges in the area of food security. These challenges include proliferation, theft, poor inventory system, poor transport and communication network. Zambia is one of the countries with these challenges and has been losing millions of dollars each year due to various challenges in managing the inventory system. In this paper, … …American Journal of Engineering and Applied Sciences, Vol. 11, Issue 3 · 29 Sep 2018 · 7,105 accessesView PDFCite
Research ArticleOpen accessIn the abstractLocation-Aware Energy-Efficient Workload Allocation in Geo Distributed Cloud EnvironmentSoha Rawas, Ahmed ZekriThe proliferation of cloud computing relied on the virtualization of the compute and storage resources and provisioning them dynamically according to users’ needs on a pay-per-use model. Massive cloud providers have geo-distributed cloud data centers to ensure service reliability, availability and satisfy user’s need. Therefore, cloud management systems are necessary to increase the profit of cloud providers and to improve … …Journal of Computer Science, Vol. 14, Issue 3 · 13 Mar 2018 · 8,041 accessesView PDFCite