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100 results for “Pathogenesis”
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EditorialOpen accessIn the abstractFocalize the Structure of Myd88 in TLR Signaling Pathway to Modulate Innate Immune Response: New Target for Old DiseasesShuai Xing, Ping ZhouAll diseases have their Achilles’ Heel to target and this is especially true for immunorelated diseases which must be treated by targeting the immune system somewhere and somehow correctly. In the most recent decade, immunologists recognized that the Toll-Like Receptor (TLR) signaling pathway in innate immune system plays a double-edged role in the pathogenesis of many notorious diseases. Although the … …American Journal of Immunology, Vol. 13, Issue 3 · 6 Sep 2017 · 7,862 accessesView PDFCite
Review ArticleOpen accessIn the abstractGeneral Aspect and Current Fluid Therapy in Cattle with Digestive DiseasesJosé-Ramiro González-Montaña, María-José Martin, Pilar AlonsoDigestive disorders therapy, both in calves and adult animals depends on the correction of dehydration, academia and the removal of D-lactate from the blood and it is possible to do it by means of fluid therapy. To do this, it is necessary to evaluate the dehydration of the animals and to evaluate some clinical signs that allow to suspect acid-base … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 3 · 4 Jul 2017 · 8,450 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Etiological Role of Microglia in Autism Spectrum Disorder: A Possible Route for Early InterventionRyan Slovak, Nitya G. ChakrabortyAutism Spectrum Disorder (ASD) is a dreaded diagnosis. The treatment options are sparse and our knowledge of its etiology is woefully lacking. The purpose of this review is to outline a unifying pathway for the pathogenesis of Autism Spectrum Disorder and to describe how this sequence could be exploited to offer early intervention to patients at high risk of developing … …American Journal of Immunology, Vol. 13, Issue 2 · 24 Jun 2017 · 7,324 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe -863 TNF-α Polymorphism and Primary Open Angle Glaucoma in EgyptiansWalaa Bayoumie Abdulwahhab El Gazzar, Shaymaa Mohamed Abd El Rahman, Mohamed Nagy Elmohamady et al.Growing evidence indicates that TNF-alpha is involved in the pathogenesis of POAG in several ways, primarly by induction of retinal ganglion cells apoptosis and therefore optic nerve degeneration. TNF-alpha and POAG relationship has been studied at the genetic level with variable results in different populations. The transcription rate and the release of the TNF-alpha cytokine have been reported to be … …American Journal of Biochemistry and Biotechnology, Vol. 13, Issue 2 · 1 Jun 2017 · 7,356 accessesView PDFCite
Research ArticleOpen accessIn the abstractSome Morphologic Features of Heart Failure with Different EtiologyDmitrij Arkadievich OleynikovDilated Cardiomyopathy (DCM) and Chronical Degenerative Valvular Disease (CDVD) are very common in dogs nowadays. However, due to modern level in oncology we can meet chemotherapy-induced cardiomyopathies more often. We have lack of information about pathogenic mechanisms underlying doxorubicin-induced cardiomyopathy (DoxCM) and features differentiating it from CDVD and DCM. The study population consisted of 46 dogs of different age, sex … …American Journal of Animal and Veterinary Sciences, Vol. 12, Issue 2 · 20 May 2017 · 7,330 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Mast Cell Distribution in Oral Lichen Planus and Lichenoid Lesions by Immunohistochemical and Histochemical AnalysisMahi Balci, Mustafa Emre ErcinThe histopathological assessment of Oral Lichen Planus (OLP) and oral lichenoid lesions is relatively subjective. The distinguishing criteria established by WHO effectively reproducible when all selection criteria were fulfilling but sometimes fail to provide a reliable diagnosis. The aim of the present study was to evaluate mast cell counts and their distribution among OLP and lichenoid lesions. The density and … …American Journal of Immunology, Vol. 12, Issue 4 · 11 Dec 2016 · 7,791 accessesView PDFCite
EditorialOpen accessIn the abstractBig Data and Parkinson’s Disease - from Understanding of Disease to Personalised MedicineYen F. Tai, Nicola PaveseThe advancement of information technology in recent years has generated a huge amount of datasets in all areas of scientific research. This has led to new opportunities to harness the 'Big Data' to improve our understanding of diseases - from investigating disease mechanisms to monitoring treatment responses. The Big Data approach is a data-driven and often hypothesis-free, way of studying … …Neuroscience International, Vol. 7, Issue 1 · 27 Jul 2016 · 7,755 accessesView PDFCite
Research ArticleOpen accessIn the abstractImmune Response, Detection of IgE and PGE2 during Vaginal Candidiasis in MiceRosymar Coutinho Lucas, Rafael Taglialegna, Carolina Nunes França et al.Vulvovaginal candidiasis is an opportunistic infection that affects most women in adult life, but the defense mechanism remains to be elucidated. Animals treated with estradiol were inoculated with Candida albicans having high virulence power. The experimental control consisted of animal groups treated with estradiol and animals without treatment that were inoculated with physiologic serum. The vaginal wall was collected, at … …American Journal of Immunology, Vol. 12, Issue 2 · 14 Jul 2016 · 6,976 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Short Term in vitro Stress Hormone Exposure on Regulatory T Cell Number and Function in AsthmaKristina E. Rehm, Gailen D. Marshall, Jr.Asthma is characterized by alterations in the immune system, including regulatory T cells (Treg). Further alterations in Treg numbers and/or function caused by stress hormones may be a contributing factor in asthma pathogenesis. We compared Treg populations and the effects of Dexamethasone (DEX, a laboratory analog of cortisol) on Treg cell number and function in patients with asthma and a … …American Journal of Immunology, Vol. 11, Issue 1 · 24 Apr 2015 · 6,608 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuronal Necrosis Due to a Lethal Epileptic Syndrome Affecting FVB Strain β-Actin Luciferase Transgenic MiceAhmed Shoieb, Rachel Allavena, Abdelazim IbrahimThe FVB is the most often inbred mouse strain used in transgenic research. This strain is recognised to be affected with a disease known as FVB Lethal Epileptic Syndrome (FLES). A case series of FVB mouse lethal epileptic syndrome in a cohort of commercially procured β actin luciferase transgenic FVB mice was diagnosed based on the clinical signs, post-mortem and … …American Journal of Animal and Veterinary Sciences, Vol. 9, Issue 4 · 10 Dec 2014 · 7,482 accessesView PDFCite