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65 results for “Mechanism of Action”
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Research ArticleOpen accessIn the abstractIn silico Modeling of α1A-Adrenoceptor: Interaction of its Normal and Mutated Active Sites with Noradrenaline as well as its Agonist and AntagonistRamchandran Vijayan, Naidu Subbarao, Birendra Nath MallickNoradrenaline, like most other neurotransmitters, acts through various adrenoceptor subtypes. The structure and active site of adrenoceptors for the binding of noradrenaline were unknown, however, such information are crucial for understanding the molecular mechanism of action of neurotransmitters, including noradrenaline, in health and disease as well as for drug designing. In this in silico study, we modeled the α1A-adrenoceptor; a … …American Journal of Biochemistry and Biotechnology, Vol. 3, Issue 4 · 31 Dec 2007 · 7,144 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Vivo Anti-malarial Tests of Nigella sativa (Black Seed) Different ExtractsH.A.A. Abdulelah, B.A.H. Zainal-AbidinNigella sativa (black seed) seeds have been used as a traditional medicine for the treatment of a variety of sicknesses including parasitic diseases. Intraperitoneal and oral administrations of ethanol, chloroform and aqueous seed extracts (50, 100, 200 and 400 µL kg-1) of N. sativa, were screened in the 4-day suppressive assays for their anti-malarial properties against Plasmodium berghei in mice. … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 8,499 accessesView PDFCite
Research ArticleOpen accessIn the abstractOn Application of Carhart Atom Pairs to Predict Anticonvulsant ActivityAlan Talevi, Julian J. Prieto, Luis E. Bruno-Blanch, Eduardo CastroAbout 50 million people in the world suffer from epilepsy, especially in childhood, adolescence and old age. Available treatment fails to control epilepsy in up to 30% of affected people. In developing countries, however, the amount of patients that do not receive adequate treatment climbs up to 75%. Moreover, the new generation of antiepileptic drugs (AEDs) causes important central and … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 3 · 30 Sep 2006 · 6,862 accessesView PDFCite
Research ArticleOpen accessIn the abstractImatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma MembraneHans Prenen, Cristiana Stefan, Bart Landuyt et al.Imatinib mesylate, the inhibitor of the KIT protein tyrosine kinase that is constitutively activated in Gastrointestinal Stromal Tumors (GISTs), has been established as the first highly effective drug in the treatment of patients with advanced GISTs. Recent studies suggest that changes in the glucose metabolism could be an additional mechanism of the anti-proliferative action of imatinib. The aim of this … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,248 accessesView PDFCite
Research ArticleOpen accessIn the abstractMulberry Fruits Extract Mitigate Vascular DementiaPratchaya Kaewkaen, Jintanaporn Wattanathorn, Terdthai Thong-Un et al.To date, Vascular Dementia (VaD) is the second most commonly found dementia following Alzheimer�s disease. Though VaD is still increasing its importance, the therapeutic efficacy is still not in satisfaction level. Therefore, the searching for an acceptable cheap and safe neuroprotective agent is in a great demand. Based on the neuroprotective and cognitive enhancing effects in alcohol neurotoxicity of mulberry … …American Journal of Applied Sciences, Vol. 9, Issue 11 · 1 Sep 2012 · 6,973 accessesView PDFCite
Research ArticleOpen accessIn the abstractDynamic Kinematics of the Plan Balanced Chain at the Planar Module 3RRelly Victoria Petrescu, Raffaella Aversa, Antonio Apicella, Florian Ion Tiberiu PetrescuAnthropomorphic robots are, as I have already said, in most of the most widespread and widely used works worldwide today, due to their ability to adapt quickly to forced work, working without breaks or breaks 24 h a day, without unpaid leave without asking for food, water, air, or salary. Anthropomorphic robots are supple, elegant, easy to configure and adapted … …Journal of Mechatronics and Robotics, Vol. 2, Issue 1 · 8 Mar 2018 · 6,948 accessesView PDFCite
Research ArticleOpen accessIn the abstractSTRATEGIC MANAGEMENT IN TIMES OF CRISISMaximilian GrohThis aim of this article is to identify unusual strategic-management matters in times of crisis. The research scope is strategic management processes, the characteristics of the processes and methods of strategic crisis management. The study reports research on the contemporary state of strategic crisis-management problems and provides an analysis of some theoretical and methodological principles. The analysis includes a classification … …American Journal of Economics and Business Administration, Vol. 6, Issue 2 · 27 Jun 2014 · 10,722 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluating the Strengths and Weaknesses of Mining Audit Data for Automated Models for Intrusion Detection in Tcpdump and Basic Security Module DataG. Mohammed Nazer, A. Arul Lawrence SelvakumarProblem statement: Intrusion Detection System (IDS) have become an important component of infrastructure protection mechanism to secure the current and emerging networks, its services and applications by detecting, alerting and taking necessary actions against the malicious activities. The network size, technology diversities and security policies make networks more challenging and hence there is a requirement for IDS which should be … …Journal of Computer Science, Vol. 8, Issue 10 · 25 Aug 2012 · 7,132 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Symbolic Threshold: A Dynamic form of the Mind as an Expression of Radiant ThinkingFelice Corona, Francesco Perrotta, Emilia Tartaglia Polcini, Carla CozzarelliProblem statement: The definition of "symbolic species" used by Terrence W. Deacon means more complete the process of monitoring the encounter between semiotics and cognitive sciences neurosemiotics better defined. Approach: The mechanism of the symbolic threshold means that it is put in place an approach to reality no longer seen as a representative of simple association, but under a restructuring … …Neuroscience International, Vol. 1, Issue 2 · 31 Dec 2010 · 16,063 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordMicrobial Diversity as a Biological Control Mechanism for Fruit Tree Diseases: A Comparative ApproachZhichao TangThe traditional methods of fruit tree pest control have long relied on chemical pesticides. This not only leads to increased resistance of pests and diseases but also adversely affects the ecological environment and fruit safety. Although biological control has gradually received attention, the current research on how to systematically use microbial diversity to achieve efficient control and prevention is still … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 1 · 8 Apr 2026 · 1,607 accessesView PDFCite