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Research ArticleOpen accessIn the abstractInsertion of poly (ethylene glycol)-lipid reduces the liposome-encapsulated hemoglobininduced thrombocytopenic reactionVibhudutta Awasthi, Beth Goins, William T. PhillipsInteraction with platelets has been recognized as a concern in the development of liposome-encapsulated hemoglobin as an oxygen carrier. This reaction causes a significant drop in circulating platelets in a rapid and transient fashion. We studied the effect of lipid bilayer charge on the magnitude of drop in circulating platelets. We also investigated the effect of post-inserted PEG-lipid on this … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,377 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of pH on the Conformation and Biological Activity of Clostridium septicum Alpha-toxin, a Pore-forming HemolysinB.M. Hang'ombe, T. Kohda, M. Mukamoto, S. KozakiThe effects of pH on the pore-forming Clostridium septicum alpha-toxin that causes myonecrosis was assessed at pH 5.0, 7.0 and 9.0 by measuring circular dichroism and its biological activity. Incubation of the toxin at pH 5.0 increased the hemolytic activity measured in murine red blood cells. On the other hand, incubation of the toxin at pH 9.0 drastically reduces the … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 2 · 30 Jun 2007 · 6,902 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of a DNA Vaccine for Immunocontraceptive Potential Against Zona Pellucida Glycoproteins in CattleC.A. Foley, S.M. Boyle, R.E. Pearson, F.C. GwazdauskasHolstein cows were administered zona pellucida (ZP) DNA vaccine and used to determine the potential of recombinant rabbit ZP glycoproteins (rZP) as immunocontraceptive antigens. Zona pellucida proteins were purified and quantified. Cows were assigned to one of four treatment groups in which plasmids encoding rabbit ZP proteins were administered, i.d., using a gene gun (ZP55, n=2; ZP75, n=2; Hep55, n=2; … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 1 · 31 Mar 2007 · 6,888 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effects of Short or Long Term FGA Treatment with or without eCG on Reproductive Performance of Ewes Bred Out-of-seasonMustafa Q. Husein, Mohammed M. Ababneh, Dia S. Abu-RumanThe objective was to evaluate the effects of intravaginal FGA sponges inserted for 4 or 12 days with or without eCG on reproductive performance of ewes out-of-season. Forty-eight anestrous ewes were assigned in equal numbers to four treatments in a 2x2 factorial design. Ewes were administered with FGA sponges on May 17 for 12 days (12-day-FGA-eCG and 12-day-FGA groups, n= … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 1 · 31 Mar 2007 · 7,485 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffects of Salmonella typhimurium Challenge on Swine Growth, Nitrogen Balance, Insulin-like Growth Factor-I, and Acute Phase ProteinsJ.A. Loughmiller, S.S. Dritz, J.L. Nelssen et al.Growing barrows were used to determine the effects of an en teric disease challenge on nutrient balance, growth, acute phase proteins, and IGF-I. Pigs were challenged on d 0 with Salmonella typhimurium (S; N=21), or unchallenged and fed ad libitum (A; n=6), or unchallenged and pair-fed the same amount of feed as a challenged pig (P; n=8). Blood was collected … …American Journal of Animal and Veterinary Sciences, Vol. 2, Issue 1 · 31 Mar 2007 · 7,552 accessesView PDFCite
Research ArticleOpen accessIn the abstractHypoglycemic and Antihyperlipidemic Effect of Four Korean Medicinal Plants in Alloxan Induced Diabetic RatsJi Su Kim, Jung Bong Ju, Chang Won Choi, Sei Chang KimTo consider potentially new hypoglycemic and antihyperlipidemic sources, aqueous extracts from four Korean medicinal plants, Chrysanthemum coronarium, Dioscorea batatas, Morus alba, Citrus unshiu, were investigated in alloxan-induced diabetic rats. To induce diabetes, 36 rats were administered alloxan orally (120 mg/kg body weight) for 2 weeks and among those 6 rats were used as a diabetic control. Effect of extracts from … …American Journal of Biochemistry and Biotechnology, Vol. 2, Issue 4 · 31 Dec 2006 · 9,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractStability of Neodymium(III) Complexes of 4-Hydroxycoumarins with Anticoagulant ActivityIrena Kostova, Irina NikolovaComplexes of neodymium(III) with 4-hydroxy-3-(3-oxo-1-phenylbutyl)-2H-1-benzopyran-2-one, 4-hydroxy-3-[1-(4-chlorophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one and 4-hydroxy-3-[1-(4-nitrophenyl)-3-oxobutyl]-2H-1-benzopyran-2-one were synthesized by mixing of water solutions of neodymium(III) nitrate and the respective ligands, in amounts equal to metal: ligand molar ratio of 1: 3. The complexes were characterized and identified by elemental analysis, conductivity, IR and 1H NMR spectral data. DTA and TGA have been applied to confirm the compositions of … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 2 · 30 Jun 2006 · 7,554 accessesView PDFCite
Research ArticleOpen accessIn the abstractInefficacy of Topical Diclofenac in Arthritic HorsesNicolás F. Villarino, Tomas J. Vispo, Marcos et al.The objective of the present study was test the anti-inflammatory efficacy of diclofenac dietilamine, applied epicutaneously at a dose rate of 0.44 mg kg-1, in a model of acute arthritis in horses. Four clinical end-points, as well as two biochemical markers, were used as surrogate markers of the required clinical response (analgesia, anti-inflammatory). Low diclofenac concentrations were measured in blood … …American Journal of Animal and Veterinary Sciences, Vol. 1, Issue 1 · 30 Jun 2006 · 7,608 accessesView PDFCite
Research ArticleOpen accessIn the abstractYoung Generation Attitudes and Awareness Towards the Implementation of Smart Card in Bahrain: An Exploratory StudyAdel I. Al-Alawi, Mohammed A. Al-AmerSmartCards are one of the latest additions to the continuing list of advancements and innovations in the world of information and communication technology. A SmartCard resembles in size and shape to a normal credit card or bank ATM card, with a microprocessor chip implanted into the plastic card. These cards are used not just as identity cards, like the earliest … …Journal of Computer Science, Vol. 2, Issue 5 · 31 May 2006 · 7,750 accessesView PDFCite
Research ArticleOpen accessIn the abstractHepatoprotective Activity of Aqueous Ethanolic Extract of Chamomile capitula in Paracetamol Intoxicated Albino RatsAjay k. Gupta, Neelam MisraHepatoprotective activity of aqueous ethanolic extract of Chamomile recutita capitula against paracetamol induced hepatic damage in albino rats was observed. In the present study the effect of aqueous ethanolic extract of Chamomile recutita capitula on blood and liver glutathione, Na+ K+- ATPase activity, serum marker enzymes, serum bilirubin, glycogen and thiobarbutiric acid reactive substances against paracetamol induced damage in rats … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 1 · 31 Mar 2006 · 18,946 accessesView PDFCite