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225 results for “two-phase”
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Research ArticleOpen accessIn the abstractA Bayesian Adaptive Design for Combination of Three Drugs in Cancer Phase I Clinical TrialsMourad Tighiouart, Quanlin Li, Steven Piantadosi, Andre RogatkoWe describe a Bayesian adaptive design for early phase cancer trials of a combination of three agents. This is an extension of an earlier work by the authors by allowing all three agents to vary during the trial and by assigning different drug combinations to cohorts of three patients. The primary objective is to estimate the Maximum Tolerated Dose (MTD) … …Current Research in Biostatistics, Vol. 6, Issue 1 · 25 Aug 2016 · 8,421 accessesView PDFCite
Research ArticleOpen accessIn the abstractApplication of Water-Soluble Polymers for Extraction Separation of Amino Acids of Various StructuresNadezhda Yakovlevna Mokshina, Dmitry Vladimirovich Bykovskiy, Gennadiy Valentinovich Shatalov, Oksana Anatolievna PakhomovaThis article actualizes the task of developing new methods for extraction separation of amino acids for the analysis and purification of target components in the production of food supplements, pharmaceuticals, agricultural products and cosmetics; it also presents the extraction separation results for binary mixtures of histidine, proline and methionine using water-soluble homo- and co-polimers with various molecular weight values. We … …American Journal of Applied Sciences, Vol. 12, Issue 12 · 10 Dec 2015 · 6,641 accessesView PDFCite
Research ArticleOpen accessIn the abstractEarly Universe in the SU(3)L⊗U—(1)X Electroweak ModelsHoang Ngoc LongWe present status of the 3-3-1 models and their implications to cosmological evolution such as inflation, phase transitions and sphalerons. The models can deal not only with the issues such as neutrino physics, dark matter, etc, but they are also able to provide quite good agreement with the Standard Cosmology: The inflation happens at the GUT scale, while phase transition … …Physics International, Vol. 7, Issue 1 · 13 Nov 2015 · 7,935 accessesView PDFCite
EditorialOpen accessIn the abstractAre we Able to Harness the Immunomodulatory Power of Cytokines for Novel Autoimmune Disease Treatments?Giuseppe Nocentini, Graziella Migliorati, Carlo RiccardiSince the end of the 1970s, interleukin 2 (IL-2) has been known as a key player in T cell expansion/activation (Watson et al., 1980). In the late 1980s, some groups used IL-2 to stimulate the immune systems of tumour patients (Jacobs et al., 1986). The idea seemed brilliant and several attempts were made, but the results were disappointing (Lim et … …American Journal of Pharmacology and Toxicology, Vol. 10, Issue 2 · 22 Oct 2015 · 7,625 accessesView PDFCite
EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite
Research ArticleOpen accessIn the abstractDEEP TRAPS SPECTRA IN UNDOPED GAN FILMS GROWN BY HYDRIDE VAPOR PHASE EPITAXY UNDER VARIOUS CONDITIONSA. Y. Polyakov, N. B. Smirnov, A. V. Govorkov et al.Decreasing the residual donors density and deep traps spectra densities in undoped GaN films grown by Hydride Vapor Phase Epitaxy (HVPE) is very important for promoting the use of such material in high-voltage/high-power rectifiers, radiation detectors. In this study we studied the effects of changing the growth temperature of undoped HVPE GaN films on these properties. The two groups of … …American Journal of Applied Sciences, Vol. 11, Issue 9 · 30 Sep 2014 · 6,901 accessesView PDFCite
Research ArticleOpen accessIn the abstractPERFORMANCE OF TOPOLOGY AWARE RELIABLE ROUTING PROTOCOL FOR LARGE SCALE VIRTUAL PRIVATE NETWORKJayanthi Gokulakrishnan, V. Thulasi BaiA network which merges the usage of the public and the private networks and uses security software for the purpose of compressing, encrypting and masking the digital packets that are being transmitted in the network is called as Virtual Private Network (VPN). In VPN, the communication between the user ends is maintained such that it appears as if the source … …Journal of Computer Science, Vol. 10, Issue 9 · 23 Jun 2014 · 6,662 accessesView PDFCite
Research ArticleOpen accessIn the abstractCOMPARATIVE STUDY OF K-MEANS AND K-MEANS++ CLUSTERING ALGORITHMS ON CRIME DOMAINBashar Aubaidan, Masnizah Mohd, Mohammed AlbaredThis study presents the results of an experimental study of two document clustering techniques which are k-means and k-means++. In particular, we compare the two main approaches in crime document clustering. The drawback of k-means is that the user needs to define the centroid point. This becomes more critical when dealing with document clustering because each center point represented by … …Journal of Computer Science, Vol. 10, Issue 7 · 19 Feb 2014 · 7,762 accessesView PDFCite
Research ArticleOpen accessIn the abstractMobile Banking and Sustainable GrowthAtul SrivastavaThe paper discusses about awareness of mobile banking services and their possible contribution towards sustainable growth. This study attempts to look into the issues regarding mobile banking services and their possible contribution in financial inclusion in India. With the help of this study author tries to focus those areas where banks can provide these mobile banking services. If this service … …American Journal of Economics and Business Administration, Vol. 5, Issue 3 · 10 Feb 2014 · 7,876 accessesView PDFCite
Research ArticleOpen accessIn the abstractPerformance Analysis of Orthogonal Frequency Division Multiplexing Based Bidirectional Relay Network in the Presence of Phase NoiseV. N. Senthil Kumaran, S. Rajkumar, S. J. ThiruvengadamIn this study, the performance of OFDM based bidirectional relay network which employs Physical Layer Network Coding (PLNC) is analyzed in the presence of phase noise. The bidirectional relay network is assumed to consist of two sources and a relay, where each node has a single antenna and operates in half duplex mode. The PLNC based OFDM system transmits high … …American Journal of Applied Sciences, Vol. 10, Issue 11 · 9 Sep 2013 · 6,639 accessesView PDFCite