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Research ArticleOpen accessIn the abstractA Short-term Management Strategy for Improving Transit Network EfficiencyAmir Samimi, Hedayat Z. Aashtiani, Abolfazl (Kouros) MohammadianImproving the service quality of the public transport systems has always been an interesting research area in the field of transportation planning. Public transit system expansion and enhancement has been known as a recognized way to improve congested metropolitan areas. In order to make a transit system more attractive to people, both long and short term management strategies should be … …American Journal of Applied Sciences, Vol. 6, Issue 2 · 28 Feb 2009 · 7,209 accessesView PDFCite
Research ArticleOpen accessIn the abstractImatinib Mesylate Inhibits Glucose Uptake in Gastrointestinal Stromal Tumor Cells by Downregulation of the Glucose Transporters Recruitment to the Plasma MembraneHans Prenen, Cristiana Stefan, Bart Landuyt et al.Imatinib mesylate, the inhibitor of the KIT protein tyrosine kinase that is constitutively activated in Gastrointestinal Stromal Tumors (GISTs), has been established as the first highly effective drug in the treatment of patients with advanced GISTs. Recent studies suggest that changes in the glucose metabolism could be an additional mechanism of the anti-proliferative action of imatinib. The aim of this … …American Journal of Biochemistry and Biotechnology, Vol. 1, Issue 2 · 30 Jun 2005 · 7,248 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordCytotoxicity and Apoptosis Prevailed by Tricyclohexyltin(IV) Dithiocarbamate Compounds Against Human Lung Carcinoma Cell Line (A549)Normah Awang, Nurul Amalina Abd Aziz, Nur Fatini Nordin, Nurul Farahana KamaludinIn Malaysia, lung cancer is a highly common kind of cancer and the leading cause of cancer-related deaths. This study examined the cytotoxicity of two new tricyclohexyltin(IV) dithiocarbamate compounds compounds, which are tricyclohexyltin(IV) N-methyl-N-benzyldithiocarbamate (C1) and tricyclohexyltin(IV) N-ethyl-N-benzyldithiocarbamate (C2), on lung carcinoma cell lines (A549) of humans. The cytotoxicity was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide (MTT) assay. Cell death mode … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 13 Jun 2024 · 4,627 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordCryptolepine Provokes Changes in the Expression of Cell Cycle Proteins in Growing CellsCharles Ansah, Nigel J. GooderhamProblem statement: Cryptolepine, the antimalarial plant alkaloid is cytotoxic to mammalian cells, but there is rather little understanding of the possible mechanisms involved in the cell-kill action of cryptolepine. Approach: We examined mammalian cells exposed to cryptolepine (0.5-5.0 μM) for effects on the cell cycle and associated alterations in the levels of major regulatory proteins using immunoblotting and flow cytometry. … …American Journal of Pharmacology and Toxicology, Vol. 4, Issue 4 · 31 Dec 2009 · 7,400 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordDrought Tolerance and Evaluation of Genetic Changes in Rice Mutant LinesAryanti Amsal, Ishak-ishakThe genetic improvement of rice through mutation induction to obtain drought resistance is essential for stable and adequate rice production would enable us to anticipate the rice yield-reducing effects of global warming. The aim of this research was to evaluate the rice mutant lines showing tolerance to drought condition and their genetic relationship using SSR markers. Mutant lines were obtained … …American Journal of Applied Sciences, Vol. 15, Issue 1 · 16 Jan 2018 · 8,553 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordNumerical Simulation of the Transient Flow in Natural Gas Transmission Lines Using a Computational Fluid Dynamic MethodPedram Ghaseminejad, Nikan NoorbeheshtUntil now, almost all tools that are used to analyze gas transportation networks are based on steady flow conditions. Some design problems can be solved by the assumption of a steady state. However, some circumstances force us to use transient analyses, which commonly include changes in customer demand, the failure of a compressor station or gas pipeline ruptures. In this … …American Journal of Applied Sciences, Vol. 10, Issue 1 · 6 Jan 2013 · 7,464 accessesView PDFCite
Research ArticleOpen accessAll words, across the recordProof of Bernhard Riemann's Functional Equation using Gamma FunctionMbaïtiga ZacharieThis study shows the use of gamma function to prove the Riemann functional equation. Two approaches had been used to solve this problem: first the value of t in the definition of the gamma function had been changed to pi nu x if only if sigma is greater than zero in the complex plane. Secondly, the Poisson summation formula is … …Journal of Mathematics and Statistics, Vol. 4, Issue 3 · 30 Sep 2008 · 7,699 accessesView PDFCite