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134 articles for “immune response”
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Research ArticleOpen accessIn the abstractImmunomodulatory and Antioxidant Effects of Stachys Japonica Miq. Ethanol Extract on Cyclophosphamide-Induced Immunosuppressed Mice and its Phytochemical CompositionXueping Jiang, Jianglong He, Yanjun Chen, Fang WangStachys japonica Miq. is an edible wild botanical drug and a traditional medicine in China. This study focused on examining the phytochemical profile and antioxidant properties of the ethanol extract of S. japonica Miq (SJEE) in vitro, as well as its immunomodulatory and antioxidant activities in cyclophosphamide (Cy)-induced immunosuppressed mice. The SJEE was analysed by UPLC-HRMS/MS. 36 Polyphenols, including flavonoids, … …American Journal of Biochemistry and Biotechnology, Vol. 22, Issue 1 · 13 Apr 2026 · 1,449 accessesView PDFCite
Literature ReviewOpen accessIn the abstractUnraveling NETosis: From Immune Mechanisms to Therapeutic InnovationsAnastasia V. Poznyak, Alexey V. Churov, Gulalek Amanmyradovna Babayeva et al.Neutrophil Extracellular Traps (NETs) are integral to immune responses, serving both protective and pathological roles in inflammatory diseases. Despite increasing recognition of NETs, significant gaps remain in understanding the nuanced mechanisms of NETosis and its implications for health and disease. This review systematically explores NETosis—the formation of NETs—by elucidating the molecular signaling pathways and cellular mechanisms involved. We highlight the … …OnLine Journal of Biological Sciences, Vol. 25, Issue 4 · 21 Feb 2026 · 1,678 accessesView PDFCite
Research ArticleOpen accessIn the abstractPredicting Antigenic Peptides Using a Multi-Level Transformer Model with Enhanced Feature SelectionAshwini S., Minu R. I., Jeevan KumarThis Antigenic Peptide (APs) prediction is one of the most important roles to improve vaccine design and interpret immune responses. This paper develops a Multi-Level Pooling-based Transformer model, which improves the accuracy and efficiency of predicting T-cell epitopes. The model utilizes peptide sequences from the Immune Epitope Database, employing a refined Kolaskar and Tongaonkar algorithm for feature extraction and a … …Journal of Computer Science, Vol. 21, Issue 7 · 17 Jul 2025 · 3,443 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Effect of Main Heat Shock Proteins on AtherosclerosisAnastasia Vladimirovna Poznyak, Alexey V. Churov et al.Atherosclerosis is a multifaceted disease characterized by complex pathogenesis involving diverse mechanisms. In recent years, the autoimmune nature of atherosclerosis has gained significant attention, emphasizing the indispensable role of the immune system in its initiation and progression. Heat Shock Proteins (HSPs) are vital for cellular functionality, facilitating cellular adaptation to environmental changes and survival under adverse conditions. Notably, various HSP … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 3 Oct 2024 · 4,354 accessesView PDFCite
Review ArticleOpen accessIn the abstractCirculating Immune Complexes as an Important Link between Inflammation and Lipid Alterations in AtherosclerosisAnastasia Vladimirovna Poznyak, Nikolay Alexandrovich Orekhov, Vasily Nikolaevich Sukhorukov et al.This review article rigorously investigates the emerging facets of atherosclerosis pathogenesis through an exhaustive examination of the existing data on the intricate interplay between lipid metabolism disorders and inflammation. A primary objective of this study is to thoroughly explore the role of Circulating Immune Complexes (CIC) as a pivotal indicator of this multifaceted interaction. The focus of this review centers … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 14 Aug 2024 · 3,926 accessesView PDFCite
Review ArticleOpen accessIn the abstractThe Impact of Di-2-Ethylhexyl Phthalate (DEHP) in Focus on the Reproductive System and Toxicity in Rat or Mammalian ModelVenkataramanaiah Poli, Srinivasulu Reddy MotireddyAbsalan, F., Saremy, S., Mansouri, E., Moghadam, M. T., Moghadam, A. R. E., & Razie, G. (2016). Effects of Mono-(2-Ethylhexyl) Phthalate and Di-(2-Ethylhexyl) Phthalate Administrations on Oocyte Meiotic Maturation, Apoptosis and Gene Quantification in Mouse Model. Cell Journal, 18(4), 503–513. https://doi.org/10.22074/cellj.2016.4717 Acevedo‐Rodriguez, A., Kauffman, A. S., Cherrington, B. D., Borges, C. S., Roepke, T. A., & Laconi, M. (2018). Emerging … …American Journal of Pharmacology and Toxicology, Vol. 19, Issue 1 · 6 Jun 2024 · 12,990 accessesView PDFCite
Review ArticleOpen accessIn the abstractOverview of Vascular Smooth Muscle Cells, Endothelial Cells, and Macrophages Apoptosis During Atherosclerosis DevelopmentAnastasia Vladimirovna Poznyak, Varvara Alexandrovna Orekhova, Vasily Nikolaevich Sukhorukov et al.Atherosclerosis is a complex disease that has garnered significant attention from researchers studying its various aspects. Its pathogenesis involves a wide array of cellular and molecular components, as well as crucial mechanisms and processes crucial for cellular and organismal functioning. Atherosclerosis is considered a chronic inflammatory disease characterized by disrupted lipid metabolism, oxidative stress, and immune response. Apoptosis, a fundamental … …OnLine Journal of Biological Sciences, Vol. 24, Issue 4 · 5 Jul 2024 · 4,675 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtective Role of Ganoderma lucidum Polysaccharides Against Stress Induced by Heavy Metals in Caenorhabditis elegansHuixiu Ma, Dehui Dai, Guicai Chen, Weilian HuAli, H., Khan, E., & Ilahi, I. (2019). Environmental Chemistry and Ecotoxicology of Hazardous Heavy Metals: Environmental Persistence, Toxicity, and Bioaccumulation. Journal of Chemistry, 2019, 6730305. https://doi.org/10.1155/2019/6730305 Aljerf, L., & Aljerf, N. (2023). Food products quality and nutrition in relation to public. Balancing health and disease. Progress in Nutrition, 25(1), e2023024. https://doi.org/10.23751/pn.v25i1.13928 Aljerf, L., Williams, M., Ajong, A. B., Onydinma, … …American Journal of Biochemistry and Biotechnology, Vol. 20, Issue 2 · 18 May 2024 · 6,947 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Living, Resident Bacterial Biofilm Populations in the Osseointegration of Oral ImplantsStephen Nelson, Honghua Hu et al.This study presents a human jawbone model which explains bone health, disease and quality and the osseointegration interphase, at the cell level. Curation of 454 pyrosequencing data obtained from 153 bone, serous-effusion and granulation samples taken from 40 patients during two-stage dental implant installation, revealed a 20 phyla jawbone microbiome with total genera of 387. Multivariate statistical ordination of curated … …Current Research in Dentistry, Vol. 14, Issue 1 · 16 Nov 2023 · 8,245 accessesView PDFCite
Case ReportOpen accessIn the abstractBacterial Biofilm Persistence in Human Jawbone Following Tooth Extraction: Implications of Surgical Debridement and Resident Population-Shift for Oral ImplantsStephen Nelson, Honghua Hu et al.Intra-radicular infection theory assumes that when an infected tooth is extracted, the main source of infection is removed and any residual contaminating bacteria are killed by the immune response, then normal healing ensues. This study investigated whether bacteria and bacterial biofilms persisted in deep bone space following tooth extraction. The study was conducted on two adult male patients seeking dental … …Current Research in Dentistry, Vol. 14, Issue 1 · 31 May 2023 · 6,861 accessesView PDFCite