Research ArticleOpen accessIn the abstractOptimizing N-linked Glycosylation Site Prediction in Human Proteins with Ensemble Stacking and Cross-ValidationMubina Malik, Jaimin UndaviaThe most frequent post-translational modification of proteins in all territories is glycosylation which impacts many biological activities. The most significant and critical of these modifications is N-linked glycosylation which is associated with various human diseases including diabetes cancer Inflammation Alzheimers and atherosclerosis. This article illustrates recent advances in knowledge of biology that are eventually targeting the computer science sector. Moreover-identification … …Journal of Computer Science, Vol. 20, Issue 12 · 20 Nov 2024 · 5,005 accessesView PDFCite
EditorialOpen accessIn the abstractNeutrophil Extracellular Traps as Therapeutic Targets for Inflammatory DiseaseRory R. KoenenNeutrophilic granulocytes, or neutrophils are the most abundant circulating white blood cell and constitute a first line of defense against pathogens. They are characterized by a large polymorphic lobular nucleus and the presence of many secretory granules in their cytoplasm. Neutrophils are essential for a functional host defense, as is evidenced by the occurrence of severe infections in individuals with … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 25 Feb 2015 · 8,740 accessesView PDFCite
EditorialOpen accessIn the abstractPLANT STEROLS LOWER CHOLESTEROL, BUT INCREASE RISK FOR CORONARY HEART DISEASEZoë Harcombe, Julien S. BakerAssmann, G., P. Cullen, J. Erbey, D.R. Ramey and F. Kannenberg et al., 2006. Plasma sitosterol elevations are associated with an increased incidence of coronary events in men: Results of a nested case-control analysis of the Prospective Cardiovascular Munster (PROCAM) study. Nutr Metab Cardiovasc Dis., 16: 13-21. BfR, 2011. Addition of plant sterols and stanols to food: Assessment of a … …OnLine Journal of Biological Sciences, Vol. 14, Issue 3 · 21 Aug 2014 · 89,005 accessesView PDFCite
Research ArticleOpen accessIn the abstractAssociation of Mycoplasma pneumoniae Infection With Ischemic Heart DiseasesAbdullah S. Assiri, Adil H. Alshehri, Osama M.S. Abdul-Wahab et al.Association of atherosclerosis and coronary artery disease well known main pathophysiologic basis for Ischemic Heart Diseases and Myocardial Infarction and due to major risk factors such as high plasma level of low density lipoprotein, low plasma level of high density lipoprotein, cigarette smoking, hypertension and diabetes mellitus, infection with few infectious agents such as Mycoplasma pneumoniae that might associated with … …American Journal of Immunology, Vol. 8, Issue 4 · 11 Oct 2012 · 8,096 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnti-Metalloproteinase-9 Activities of Selected Indonesian Zingiberaceae Rhizome Extracts in Lipopolysaccharide-Induced Human Vascular Endothelial Cells In VitroYantiProblem statement: Atherosclerosis is associated with chronic inflammation triggered by bacterial infection that activates the breakdown of extracellular matrix protein by matrix Metalloproteinases (MMPs). Zingiberaceae, a group of tropical food crops grown in Indonesia and other Southeast Asia regions, has been traditionally used for food coloring, seasoning, culinary and medicinal purposes. However, its efficacy as natural vascular protection has not … …American Journal of Biochemistry and Biotechnology, Vol. 7, Issue 1 · 27 May 2011 · 7,874 accessesView PDFCite
Research ArticleOpen accessIn the abstractHypolipidemic Effects of Coenzyme Q10 in Experimentally Induced Hypercholesterolemic Model in Female RatsAtef M. Al-AttarProblem statement: Hyperlipidemia is well known to play a main role in the development of atherosclerosis. It is characterized by abnormally elevated cholesterol, triglyceride, low density lipoprotein cholesterol and very low density lipoprotein cholesterol levels in the blood. It has been recognized for many years that hypercholesterolemia is a major risk factor for cardiovascular diseases such as atherosclerosis, myocardial infraction, … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 1 · 31 Mar 2010 · 45,651 accessesView PDFCite
EditorialOpen accessIn the abstractIs Rerum® the New Coley's Vaccine?Marco RuggieroColey's Vaccine and Cancer Immunotherapy Dr. William B. Coley is credited for having been the first to translate the observation of an association between bacterial infections, high fever and cancer remission into a successful cancer treatment. However, it is worth noting that such an association dates back to at least one century before Coley's times; as Wiemann and Starnes from … …American Journal of Immunology, Vol. 13, Issue 2 · 31 May 2017 · 12,285 accessesView PDFCite
Research ArticleOpen accessIn the abstractDiagnosis of Cardiovascular Diseases with Bayesian ClassifiersAlaa Elsayad, Mahmoud FakhrCardiovascular disease or atherosclerosis is any disease affecting the cardiovascular system. They include coronary heart disease, raised blood pressure, cerebrovascular disease, peripheral artery disease, rheumatic heart disease, congenital heart disease and heart failure. They are treated by cardiologists, thoracic surgeons, vascular surgeons, neurologists and interventional radiologists. The diagnosis is an important yet complicated task that needs to be done accurately … …Journal of Computer Science, Vol. 11, Issue 2 · 25 Mar 2015 · 7,503 accessesView PDFCite
Research ArticleOpen accessIn the abstractInhibition of Interleukin-6 Expression by Curcumin in Rat Vascular Smooth Muscle Explants In VitroYanti, Stephanie, Yuliani et al.In atherosclerotic plaques, infectious agents from microbes may release Lipopolysaccharide (LPS) and heat shock proteins that can stimulate the production of mediators, i.e., pro-inflammatory cytokines, by vascular endothelial cells and Smooth Muscle Cells (SMCs). The elevated level of Interleukin-6 (IL-6) is strongly associated with the development of atherosclerosis. Here, we investigated whether curcumin isolated from the rhizome of Curcuma longa … …American Journal of Biochemistry and Biotechnology, Vol. 10, Issue 4 · 15 Dec 2014 · 6,777 accessesView PDFCite