Sign inSubmit
Tips: “quotes” for a phrase · author:Lee · a DOI goes straight to its article

140 articles for “Drug Problem”
Set a search alert
Also matching:2 special issues
Research ArticleOpen accessIn the abstractFrequency of P/S(XX)P Duplication and FRFE, Absence of LYP in P6Gag of Indian Human Immunodeficiency Virus-1 Subtype C IsolatesKrutika Wadekar, Sudhanshu Pandey, Preeti Jain et al.Problem statement: The presence of a p6 domain at the C-terminus of the Gag polyprotein is a characteristic feature of HIV-1 and other primate lentiviruses. The p6Gag protein is considered as a major phosphoprotein in mature HIV-1 virions and is involved in the viral assembly and budding process. Sequence variation in the p6gag region in HIV-1 has been associated with … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,529 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Resistance to Human Immunodeficiency Virus Protease Inhibitors Using Molecular Mechanics and Machine Learning StrategiesA. Harishchander, D. Alex Anand, Sanjib SenapatiProblem statement: Drug resistance is the most important factor, which influences the failure of current HIV therapies. So, the ability to predict the drug resistance of HIV-1 protease mutants will be useful in developing more effective and longer lasting treatment regimens. Approach: Drug resistance of HIV-1 protease is predicted with two current protease inhibitors (Indinavir and Saquinavir). The problem was … …Current Research in Medicine, Vol. 1, Issue 2 · 31 Oct 2010 · 7,204 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Role of Molam in Solving Social ProblemsSitthisak ChampadaengProblem statement: Mo-lam is the most popular Isan Local Song. Its rhythm and message influenced people’s feeling and thought. The objectives of this research were to study: (1) the moving force in using the media of Mo-lam for solving social problem, (2) the role of Mo-lam and social problem solving and (3) the effect of campaign with the sharing in … …Journal of Social Sciences, Vol. 6, Issue 3 · 30 Sep 2010 · 7,973 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethamphetamine Regulation of Sulfotransferases in Rat Liver and BrainTianyan Zhou, Chaoqun Huang, Yue Chen et al.Problem statement: Sulfotransferases (SULTs) are important phase II drug metabolizing enzymes. They also regulate the biological activities of various hormones. To the best of our knowledge, psychostimulants regulation of SULTs is basically not studied except one article reported that Methamphetamine (METH) treatment induced rat amygdale rSULT1A1 mRNA 4.3 fold by using microarray method to identify a series of candidate genes … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 7,683 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Prospective Evaluation of Antihypertensive Medications Safety and Efficacy in United Arab Emirates Private HospitalsMuaed Jamal Alomar, Claire Caroline StrauchProblem statement: Hypertension is one of the most important risk factors for heart and cardiovascular diseases in the United Arab Emirates (UAE). Evaluation of the safety and efficacy of antihypertensive medications in UAE private hospitals is important. The importance arises because of the high prevalence of hypertension in this multicultural region. This study evaluated the use of antihypertensive medications among … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 2 · 30 Jun 2010 · 8,312 accessesView PDFCite
Research ArticleOpen accessIn the abstractPrevalence and Antibiotics Susceptibility of Uropathogens in Patients from a Rural Environment, TamilnaduMaripandi Arjunan, Ali A. Al-Salamah, M. AmuthanProblem statement: Urinary Tract Infections (UTIs) in human, rural environment cause significant morbidity due to insanitary condition, lack of knowledge of personal hygiene, lack of patient’s compliance and economic burden. In our study, the bacterial etiologies and the resistance patterns found in human with serious UTIs and selecting optimal antimicrobial therapy. Approach: A total of 105 patients first morning mid … …American Journal of Infectious Diseases, Vol. 6, Issue 2 · 30 Jun 2010 · 8,704 accessesView PDFCite
Research ArticleOpen accessIn the abstractDrug Susceptibility and Molecular Epidemiology of Pseudomonas aeruginosa Isolated in a Burn UnitHassan Salimi, Parviz Owlia, Bagher Yakhchali, Abdolaziz Rastegar LariProblem statement: Pseudomonas aeruginosa is an opportunistic pathogen that still develops life-threatening infections in patients with immunological system defects, like burn patients, especially in developing countries. Since this bacterium is naturally resistant to many drugs and is able to get resistance to all effective antibiotics, the infection with this organism is particularly problematic condition for patients. This study was design … …American Journal of Infectious Diseases, Vol. 5, Issue 4 · 31 Dec 2009 · 6,992 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn vitro Anti Plasmodial Activity of Enicostemma littoraleSanket Soni, Sarita GuptaProblem statement: Malaria is a prevalent disease in India. The problem of drug resistance is worsening. Hence, new effective and affordable antimalarial drugs are very much needed. The long-established use of quinine and the more recent introduction of artemisinin as highly effective anti malarials demonstrate that plant species are an important resource for the discovery of new anti malarial agents. … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 7,707 accessesView PDFCite
Research ArticleOpen accessIn the abstractStudies on Emergence of Drug Resistance in HIV Associated Bacterial Urinary Tract InfectionsS. D. Deokar, M. G. BodhankarProblem statement: This study was designed to document the prevalence of HIV associated urinary tract infections in Barshi Tahsil. Such studies had not been researched out before in this region. Approach: The study included samples from 123 HIV reactive and 40 HIV non-reactive patients. In both, mid stream samples were collected and processed to examine for bacterial opportunistic pathogens. The … …American Journal of Infectious Diseases, Vol. 5, Issue 3 · 30 Sep 2009 · 8,468 accessesView PDFCite
Research ArticleOpen accessIn the abstractP-Glycoprotein-Mediated Efflux and Drug Sequestration in Lysosomes Confer Advantages of K562 Multidrug Resistance Sublines to Survive Prolonged Exposure to Cytotoxic AgentsNathupakorn Dechsupa, Samlee MankhetkornProblem statement: Cellular drug resistance to anticancer agents is major obstacle in cancer chemotherapy and the mechanisms by which these MDR cells possess for protecting themselves to survive prolonged exposure to cytotoxic agents still debating. The study aimed to clarify the role of P-glycoprotein (Pgp) and enhanced drug sequestration in lysosomes to confer the multidrug resistance K562 cells with varied … …American Journal of Applied Sciences, Vol. 6, Issue 9 · 30 Sep 2009 · 7,504 accessesView PDFCite