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83 results for “Dosage”
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EditorialOpen accessIn the abstractImpact of Quantitative Pharmacology on Drug DevelopmentAna Ruiz-Garcia, Kourosh ParivarThesuccess of drug development rests over two well defined pillars, a goodunderstanding of the drug’s clinical pharmacology and the appropriate targetpopulation for whom the clinical use is intended. The label for human prescription drugsrequires a good understanding of the pharmacological effects (pharmacodynamicsor PD) and the mechanism of action of the drug as well as detailed informationof the drug’s Pharmacokinetics (PK): … …American Journal of Pharmacology and Toxicology, Vol. 9, Issue 4 · 24 Apr 2015 · 7,158 accessesView PDFCite
Research ArticleOpen accessIn the abstractRemoving Boron from an Aqueous Solution Using Turmeric Extract-Aided Coagulation-FlocculationAzhar Abdul Halim, Nur Hanani Thaldiri, Normah Awang, Mohd Talib LatifProblem statement: Boron exists in an environment naturally either through weathering of rocks or volcanic activity but due to anthropogenic activity, boron had been distributed widely into our surroundings. Boron was a problematic pollutant due to the difficulty to remove it from the water. Turmeric which had been widely used as a spice and traditional medicine, were investigated to determine … …American Journal of Environmental Sciences, Vol. 8, Issue 3 · 15 Jun 2012 · 8,329 accessesView PDFCite
Research ArticleOpen accessIn the abstractPeriodic Validation of High Antidiabetic Potentials of Unripe Plantain in Comparison with Glibenclamide and FansidarE. O. Jimmy, M. A. OkonProblem statement: The antidiabetic potentials of aqueous extract of musa paradisciaca (unripe plantain fruit) were investigated in alloxan induced diabetic rats. The extract at a dosage of 120 mg kg-1 produced a significant (p<0.001) reduction in glucose level by 85% on day 7, 78% on day 14, 64% on day 21 and 44% on day 28. Approach: The extract at … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 1 · 22 Mar 2012 · 7,997 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptimizing Coagulation Process for Low to High Turbidity Waters Using Aluminum and Iron SaltsAkbar Baghvand, Ali Daryabeigi Zand, Nasser Mehrdadi, Abdolreza KarbassiProblem statement: Turbid waters, containing colloidal particles, are normally treated by coagulation-flocculation followed by clarification. Ferric chloride and alum, which are the most common types of coagulants in water treatment plants of Iran as well as many other countries, were investigated with the aim of determining their capabilities to reduce turbidity of drinking water. Turbidity was added as kaolin. Optimization … …American Journal of Environmental Sciences, Vol. 6, Issue 5 · 31 Oct 2010 · 21,079 accessesView PDFCite
Research ArticleOpen accessIn the abstractRemoval of Cadmium, Copper, Lead and Nickel from Aqueous Solution by White, Yellow and Red United Arab Emirates SandL. Pappalardo, F. Jumean, N. AbdoProblem statement: To remove toxic heavy metal ions from wastewater using local sand as a low cost adsorbent. Approach: Removal efficiency of Cd(II), Cu(II), Pb(II) and Ni(II) from aqueous solution by white, yellow and red UAE sand was investigated at 25.0°C using the methods of batch equilibrium adsorption and column filtration. In each case, a mixture containing 20 ppm of … …American Journal of Environmental Sciences, Vol. 6, Issue 1 · 28 Feb 2010 · 7,600 accessesView PDFCite
Research ArticleOpen accessIn the abstractBehavior of Stabilized Peat Soils in Unconfined Compression TestsWong Leong Sing, Roslan Hashim, Faisal Haji AliProblem statement: Deep stabilized peat columns were known to be economical at forming foundations to support highway embankments constructed on deep peat land. However, failure in the formation of the columns with adequate strength was often attributed to unsuitable type and insufficient dosage of binder added to the soil. Organic matter in peat was known to impede the cementing process … …American Journal of Engineering and Applied Sciences, Vol. 1, Issue 4 · 31 Dec 2008 · 7,452 accessesView PDFCite
Research ArticleOpen accessIn the abstractAnalysis of Certain Tetracyclines and Oxytetracyclines through Charge Transfer ComplexationKhairi M.S. FahelelbomProblem statement: Several studies were carried out to develop and validate a simple, rapid and accurate spectrophotometric method for the analysis of tetracycline (TC) and oxytetracycline (OTC) in the pure form and in pharmaceutical dosage forms, despite the varieties of these analytical techniques, the literature revealed that no spectrophotometric method for determination of tetracycline and oxytetracycline using charge transfer complexation … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 3 · 30 Sep 2008 · 8,528 accessesView PDFCite
Research ArticleOpen accessIn the abstractEmploying New Mathematical Models and Equations to Evaluate Risk-Benefit Criteria of Clinical TherapeuticsDa Yong Lu, Ting Ren Lu, Jian DingCurrent preclinical and clinical evaluation of a drugs or therapy is at first to find out a maximum toxicity tolerance, which is overall fixed. The potential therapeutic dosage will be ranged just lower or within the periphery of these maximum tolerant data. A hidden acceptance among general researchers lies as the toxicity concentration of a drug is always the same … …OnLine Journal of Biological Sciences, Vol. 7, Issue 1 · 30 Jun 2007 · 6,825 accessesView PDFCite
Research ArticleOpen accessIn the abstractZonisamide: The Arizona ExperienceK.J. Oommen, Enriqe LabadieZonisamide (ZNS) is a new antiepileptic drug initially introduced in Europe, Japan and the United States (US) in the late 1980’s and was the first such drug to be clinically tested in the US, since the marketing of valproic acid in 1978. Reports of nephrolithiasis by European and US investigators resulted in the trials being terminated in the US during … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 2 · 30 Jun 2007 · 7,164 accessesView PDFCite
Research ArticleOpen accessIn the abstractSpectrofluorimetric Determination of Certain Fluoroquinolones Through Charge Transfer Complex FormationH. Salem, L. Fada, W. KhaterA highly sensitive spectrofluorimetric method was developed for the first time, for the analysis of ten fluoroquinolones (FQs) antibacterials, namely amifloxacin (AMI), ciprofloxacin (CIP), difloxacin (DIF), enoxacin (ENO), enrofloxacin (ENR), lomefloxacin (LOM), levofloxacin (LEV), norfloxacin (NOR), ofloxacin (OFL) and pefloxacin (PEF) in their pharmaceutical dosage forms or in biological fluids through charge transfer (CT) complex formation with bromanil (BRO). The … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 7,629 accessesView PDFCite