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403 results for “W-Shape”
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Research ArticleOpen accessIn the abstractUltrastructural Evidences of Hepatitis B Infection in Human Liver Biopsies Disclose Complex Assembly and Morphogenesis Pathways for Hepatitis B VirusViviana Falcon, Ivon Menéndez, Nelson Acosta-Rivero et al.Despite of recent advances on acknowledge of hepatitis B virus (HBV) structure and biology, little is known about the morphogenesis and release of virions. In this study, the ultrastructural analysis of HBV components in liver biopsies from chronically HBV-infected patients disclosed complex assembly and morphogenesis pathways for HBV. HBV core (HBcAg) and surface (HBsAg) antigens were specifically identified in all … …American Journal of Infectious Diseases, Vol. 4, Issue 2 · 30 Jun 2008 · 7,091 accessesView PDFCite
Research ArticleOpen accessIn the abstractFollowing the Heart: The History of the J-Curve in Stroke RiskShoshana Reshef, Daniel ReshefReports of a J-shaped relationship between blood pressure and ischemic stroke are rare. The purpose of this study was to trace the published history of the J-curve theory as it relates to blood pressure, ischemic heart disease and eventually ischemic stroke. The J-curve publications on the relationship between Diastolic Blood Pressure (DBP) and ischemic stroke suggest that in certain populations, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,356 accessesView PDFCite
Research ArticleOpen accessIn the abstractNeuroprotection Afforded by GABA Against Oxygen-Glucose Deprivation-Induced Injury in Rat Cortical Brain Slices: An Hormetic Dose-Response EffectLorenzo Ricci, Massimo Valoti, Giampietro Sgaragli, Maria FrosiniThe aim of the present investigation was to assess neuroprotection exerted by GABA (100 nM-100 mM) in rat cortical brain slices subjected to oxygen-glucose deprivation and reoxygenation. Neuronal injury and neuroprotection were assessed by measuring the release of glutamate and lactate dehydrogenase and tissue water content. Results demonstrate that GABA exerted neuroprotective effects according to a U-shaped, hormetic-like, concentration-response curve, … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,166 accessesView PDFCite
Research ArticleOpen accessIn the abstractMicronutrients, Hormesis and the Aptitude for the Maturation of RegulationJaap C. HanekampThe potential of hormesis as the default model to assess and manage chemicals is considered in relation to micronutrients. It is pointed out that micronutrients, despite their well-known U-shaped dose-response curve, are assessed and managed only with excess-exposure in mind. Hereby a schism between health and safety is unjustifiably realized. This proves to be the conundrum of basically all chemicals … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 7,577 accessesView PDFCite
Research ArticleOpen accessIn the abstractOn the Hormetic Behaviour of Drugs Binding to Different Redox States of Amine Oxidase EnzymesDeepak Narang, G. Reid McDonald, David J. Smith et al.Classical monoamine oxidases and copper-containing semicarbazide-sensitive amine oxidases are drug targets for a variety of established and novel pharmaceuticals used to treat conditions such as depression, Parkinsonism and inflammatory disorders. Development of enzyme inhibitors, both historically and currently, assumes an underlying adherence of these enzymes to Michaelis-Menten kinetic principles. In this mini-review, we discuss historical data from several laboratories and … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 6,928 accessesView PDFCite
Research ArticleOpen accessIn the abstractHormetic and Non-Hormetic Dose-Response Functions in Stress Effects on Memory and Synaptic Plasticity: Issues and MechanismsPhillip R. Zoladz, David M. DiamondOver a century of behavioral research has shown that stress can exert both positive and negative effects on memory. We have explored the idea that the complex effects of stress on learning and memory can be characterized by hormetic- and non-hormetic dose-response functions, in which stress may either stimulate or impair brain memory mechanisms, depending, in part, on the timing … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 1 · 31 Mar 2008 · 8,184 accessesView PDFCite
Research ArticleOpen accessIn the abstractOld and Modern Construction Materials In Yemen: The Effect In Building Construction In Sana’aISSA A.M. Al_Kahtani, Suhaib Y.K. Al-DarziSana’a city in Yemen is one of the oldest cities in the worlds, which has different forms of building built with different types of materials. In the present work, the old and new forms of building construction and the building materials used in Sana’a, the sources available for the new material, the effects of new material usage on building forms … …Journal of Social Sciences, Vol. 3, Issue 3 · 30 Sep 2007 · 9,296 accessesView PDFCite
Research ArticleOpen accessIn the abstractDesign, Fabrication, and Testing of a Membrane Piezoelectric Tactile Sensor with Four Sensing ElementsAshkan Mirbagheri, Javad Dargahi, Siamak Najarian, Farhad Tabatabai GhomsheWe presented design, fabrication, and testing of a novel membrane tactile sensing system with only four sensing elements. By using membrane stress combined with triangulation approach, it was possible to overcome the problems such as cross-talk between sensing elements, fragility, and complexity. The fabrication of the sensing elements performed using photolithographic and etching techniques. Position, orientation, and magnitude of applied … …American Journal of Applied Sciences, Vol. 4, Issue 9 · 30 Sep 2007 · 7,072 accessesView PDFCite
Research ArticleOpen accessIn the abstractDevelopment of Pulsed Laser Deposition System for the Formation of Web-liked Carbon NanotubesNoorhana Yahya, Beh Hoe Guan, Mansor HashimThis work reports on our earnest effort to develop a pulsed laser ablation deposition system for the production of carbon nanotubes (CNTs). The correct condition such as the pressure, ablation time, power of laser will result in different structures and morphology of the tubes. A T-shaped stainless steel chamber was designed. Nd:YAG laser with 532 nm wavelength, 10.54W output power … …American Journal of Applied Sciences, Vol. 2, Issue 11 · 30 Nov 2005 · 7,036 accessesView PDFCite
Research ArticleOpen accessIn the abstractInvestigation of Flow Energy Dissipation over Different Stepped SpillwaysG. A. Barani, M. B. Rahnama, N. SohrabipoorIn this study, to investigate energy dissipation of flow overstepped spillways of different step shapes, a physical wooden model has been built in the Shahid Bahonar University’s hydraulics lab. This model with 41.41° slope has 84 cm height and 21 steps. Each step has 4 cm height, 4.5 cm width and 30 cm length. Experiments have been carried out for … …American Journal of Applied Sciences, Vol. 2, Issue 6 · 30 Jun 2005 · 7,475 accessesView PDFCite