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72 articles for “oral administration”
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Research ArticleOpen accessIn the abstractFrom Humans to Dogs and Back: The Translational Lesson of Metronomic ChemotherapyAlessio Pierini, Guido Bocci, Mario Giorgi et al.The main priority in veterinary oncology is to maintain patient quality of life. It is important that new chemotherapy strategies aim to minimize side effects, thus making the treatment attractive for owners as well as their pets. Metronomic chemotherapy has been shown to have an important stabilizing effect on human cancer (including chemotherapy-resistant disease) resulting in prolonged clinical benefit. In … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 4 · 31 Dec 2012 · 7,738 accessesView PDFCite
Research ArticleOpen accessIn the abstractProtection of Terminalia belerica Roxb. Against Iron Overload Induced Liver Toxicity: An Account of Its Reducing and Iron Chelating CapacityBibhabasu Hazra, Rhitajit Sarkar, Nripendranath MandalExcess iron deposition in the liver catalyses the production of Reactive Oxygen Species (ROS) which in turn initiate oxidative damage of protein and nucleic acids leading to several human diseases. The fruits of Terminalia Belerica Roxb. (TB) has been most commonly used not only in stimulating gastrointestinal health, but also in treatment of various hepatic disorders. The present study was … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 3 · 20 Nov 2012 · 7,989 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcute and Subchronic Toxicity of Mulberry FruitsJintanaporn Wattanathorn, Wipawee Thukummee, Cholathip Thipkaew et al.At present, the application of phytomedicine worldwide is substantial increase. The data of the acute and subchronic toxicity studies on medicinal plants or fruits and vegetables used for medicinal purposes should be obtained in order to increase the confidence in its safety to human, particularly for the application as functional food. Despite the widely consumption of mulberry (Morus alba L, … …American Journal of Agricultural and Biological Sciences, Vol. 7, Issue 3 · 19 Sep 2012 · 33,868 accessesView PDFCite
Research ArticleOpen accessIn the abstractAluminium Chloride Exposure Had No Effects on the Epididymis of Wistar RatsSamuel Adeniyi Ojo, Joseph Olajide Hambolu, Sunday Samuel Adebisi, Adebayo Adekunle BuraimohAluminium is a ubiquitous element and one of the trace elements with moderate toxic effect on living organism. It is generally a recognized neurotoxin that is believed to be at the root cause of Alzheimer’s disease and third most abundant element in the earth’s crust after oxygen and silicon. Traditionally, aluminium has been considered as nontoxic to humans. However, in … …Current Research in Medicine, Vol. 3, Issue 2 · 25 Aug 2012 · 7,453 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicological Evaluation of Murraya Paniculata (L.) Leaves Extract on RodentsR. K. Goel, C. V. Rao, A. Singh, M. K. GautamProblem statement: Present study was aimed to explore the acute and sub-acute toxicities studies with orally administered 50% ethanolic leaves extract of Murraya paniculata. Approach: Acute toxicity (oral single dose, 50-2000 mg kg-1) includes any mortality and CNS and ANS toxicities in mice while, sub-acute toxicity (100, 200 and 400 mg kg-1, orally and once daily for 28 days) includes … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 2 · 9 Jul 2012 · 8,076 accessesView PDFCite
Research ArticleOpen accessIn the abstractDeveloping a System for Antibacterial Treatment of Dental Caries using Culture Based ApproachM. Mishra, S. Ghosh, L. E. Alex et al.Problem statement: Dental caries is a chronic disease worldwide, caused mainly by microbes. The orthograde approaches still remain the only option of treatment. Lack of rapid antibiotic sensitivity determination of the dental pathogen is a rate limiting step in the field of Dental Microbiology. Approach: The culture dependent analysis was used for the study of oral microflora from five healthy … …OnLine Journal of Biological Sciences, Vol. 12, Issue 2 · 18 May 2012 · 9,061 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Dietary Kaempferia parviflora on Ischemic Brain Injury in the ratWathita Phachonpai, Sinthuporn Maharun, Supaporn Muchimapura et al.Problem statement: Stroke often causes irreversible neuronal damage and related behavioral deficits. The lack of effective and widely applicable pharmacological treatments for ischemic stroke patients may explain a growing interest in traditional plant medicines. We investigated the ability of consuming Kaempferia parviflora extract, a Thai medicinal plant reputed for neuroprotective effects against brain damage, reduced infarct volume and improve neurological … …OnLine Journal of Biological Sciences, Vol. 12, Issue 1 · 20 Mar 2012 · 9,088 accessesView PDFCite
Research ArticleOpen accessIn the abstractEvaluation of Hyypoglycemic and Hypolipidemic Activity of Nyctanthes Arbortristis Linn against Streptozotocin Induced Diabetic RatsKrishna Murti, Manish Kaushik, Aditi KaushikProblem statement: The present study was aimed to explore the hypoglycemic and hypolipidemic activity of Nyctanthes arbortristis linn roots against Streptozotocin (STZ) induced experimental rats. Approach: Ethanolic extract of roots of Nyctanthes arbortristis was administered to streptozotocin induced rats.Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Nyctanthes arbortristis (200 … …American Journal of Pharmacology and Toxicology, Vol. 7, Issue 1 · 3 Mar 2012 · 7,814 accessesView PDFCite
Research ArticleOpen accessIn the abstractTramadol Vs Tapentadol: Anew Horizon in Pain Treatment?Mario GiorgiProblem statement: Acute and chronic pain is a common presenting sign in animal species and human beings. Approach: Classical opioids provide very effective pain relief, although they may be less effective in the treatment of chronic pain due to their limited therapeutic windows and the induced opioid receptor down regulation. Atypical opioids, such as tramadol and tapentadol, have a dual … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 25 Feb 2012 · 17,871 accessesView PDFCite
Research ArticleOpen accessIn the abstractToxicological Evaluation of Aspilia Africana Leaf Extracts in MiceO. O.K. Oko, E. A. Agiang, E. E. Osim, O. R. AsuquoProblem statement: The degree of toxicity of crude extracts of Aspilia Africana (Bush marigold) leaf on the basis of routes and dosages of administration were investigated. 204 healthy, male Swiss albino mice (20-25g) were used in three consecutive studies. Approach: In the first and second study, oral and intraperitoneal doses of 100, 500, 1000, 2000 and 4000 mg kg-1 body … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 3 · 28 Nov 2011 · 8,184 accessesView PDFCite