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68 articles for “in vitro Analysis”
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Research ArticleOpen accessIn the abstractIn Silico and in Vitro Studies: Tryparedoxin Peroxidase Inhibitor Activity of Methotrexate for Antileishmanial ActivityRavi Kumar Gundampati, Shraddha Sahu, Avinash Kumar Srivastava et al.In order to understand the mechanism of molecular interactions at the active site of Tryparedoxin Peroxidase (Try P), homology modeling and docking studies were performed. We generated a Three-Dimensional (3D) model of target protein based on the Crystal structure of Leishmania Major Try PI (PDB ID: 3TUE) using modeler software. Docking analysis was carried out to study the effects of … …American Journal of Infectious Diseases, Vol. 9, Issue 4 · 28 Nov 2013 · 7,894 accessesView PDFCite
Research ArticleOpen accessIn the abstractModulation of the GABAA Receptor by Srif in Rat ThalamusFatiha Chigr, Mariama El Ouahli, Ghizlane Er-Raoui et al.Somatostatin has been reported to modulate GABAA receptor complex in many brain structures. This study was conducted to investigate somatostatin modulation of the GABAA receptor binding in several rat diencephalic structures, focusing primarily on the thalamus, as this structure plays important roles. Animals were assigned to control conditions. Changes in specific binding of GABAA receptor as labelled with [35S]t-Butylbicyclophosphorothionate (TBPS) … …Neuroscience International, Vol. 3, Issue 2 · 14 Sep 2012 · 6,967 accessesView PDFCite
Research ArticleOpen accessIn the abstractSynthesis and Characterization of Organotin(IV) Complexes Derived of 2-amino-5-nitrobenzoic Acid: In vitro Antibacterial Screening ActivityYip-Foo Win, Siang-Guan Teoh, M. R. Vikneswaran et al.Problem statement: Tremendous studies have been carried out on organotin(IV) complexes derivatives of carboxylate anions. However, the synthesis and characterization as well as the in vitro antibacterial screening activity of organotin(IV) carboxylate derived of 2-amino-5-nitrobenzoic acid have not been carried out. Approach: Organotin(IV) carboxylate complexes derivative of 2-amino-5-nitrobenzoic acid, 2-NH2-5-NO2-C6H3COOH have been successfully synthesized. The acid and complexes obtained were … …American Journal of Applied Sciences, Vol. 7, Issue 7 · 31 Jul 2010 · 8,801 accessesView PDFCite
Research ArticleOpen accessIn the abstractPreparation and Properties of Copolyanhydrides Based on 2-Hexadecylsuccinic Acid and Sebacic AcidYousef Hamdan, Xiangmei Jiang, Kaixun Huang, Kaichao YuPoly(2-hexadecylsuccinic acid-sebacic acid) (P(HSA-SA)) copolymers have been prepared by melt polycondensation. The copolymers were characterized by FT-IR, 1HNMR, gel permeation chromatography (GPC), differential scanning calorimetry (DSC) and thermal gravimetric analysis (TGA). In vitro studies showed that all our prepared copolymers are degradable in phosphate buffer at 37°C. The release profiles of hydrophilic model drug, ciprofloxcin hydrochloride, from the copolymers, follow … …American Journal of Applied Sciences, Vol. 4, Issue 3 · 31 Mar 2007 · 7,430 accessesView PDFCite
Research ArticleOpen accessIn the abstractUse of Novel Triphenyltin (IV) Dithiocarbamate Compounds in Assessing the Cytotoxicity and Mode of Cell Death of Acute Lymphoblastic Leukemia Cell Lines, CCRF CEM (CCL-119)Normah Awang, Nur Hidayah Hasrin, Nurul Farahana Kamaludin et al.Chemotherapy and radiotherapy are often used to treat Acute Lymphoblastic Leukemia (ALL). However, the resistance problem of treatment using the current drug in ALL patients has decreased the effectiveness of such therapy. Therefore, a study needs to be conducted to identify the potential of new anticancer agents. Organotin (IV) dithiocarbamate, an organometallic compound, causes toxic effects on cancer cells in … …OnLine Journal of Biological Sciences, Vol. 23, Issue 2 · 10 Mar 2023 · 5,161 accessesView PDFCite
Research ArticleOpen accessIn the abstractAcetylation Process and Antioxidant Activity of a Polysaccharide from Loquat (Eriobotrya japonica) LeavesYiting Xue, Xiao Ding, Ze Zhang et al.Chemical modifications of polysaccharides can provide an opportunity to obtain new agents with possible therapeutic uses. In this study, a water-soluble polysaccharide extracted from Loquat Leaves (coded LLPs) was purified by the column chromatography, which was used to investigate its acetylation process by the acetic anhydride method. The Degree of Substitution (DS) was used as the index, the effect of … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 4 · 1 Jan 2021 · 7,059 accessesView PDFCite
Research ArticleOpen accessIn the abstractA Polysaccharide-Rich Fraction Derived from Oviductus ranae with Antioxidant and Immunomodulatory PotentialsXiaojin Yu, Xinyu Wang, Xinyu Liu et al.Oviductus ranae, an animal-based traditional Chinese medicinal material listed in Chinese Pharmacopeia is widely consumed as tonic, approximately twenty Oviductus ranae-related functional foods have been approved on the market by National Medical Products Administration in China. Proteins are well-defined bioconstituents in Oviductus ranae, little information is availabe on its polysaccharides. In present work, a Polysaccharide-Rich fraction (POR-3) was fractionated from … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 3 · 13 Sep 2020 · 6,627 accessesView PDFCite
Research ArticleOpen accessIn the abstractOptimization of Chelating Process of Polysaccharides of Lyophyllum decastes with Zinc and Its Antioxidant ActivityBing Xu, Yi Dai, Jing Hong, Yiyong ChenIn this study, polysaccharides of Lyophyllum decastes (LDS) were used as raw material. The chelating rate was set as the index, the effect of chelating time, mass ratio and initial mass concentration on chelating rate was investigated. Response surface method was used to optimize the preparation technology of LDS and Zinc (Ⅱ) chelate (LDS-Zn) based on single factor experiments. LDS-Zn … …Current Research in Bioinformatics, Vol. 9, Issue 1 · 26 Aug 2020 · 11,769 accessesView PDFCite
Research ArticleOpen accessIn the abstractIn Silico Cholinesterase and Monoamine Oxidase Inhibitory Activities of Perillaldehyde and D-Limonene, Main Compounds of Essential Oil of Algerian Ammodaucus leucotrichusNesrine Sadaoui-Smadhi, Souad Khemili-Talbi, Wadood Abdul et al.In a continuation of our previous work for the exploration of novel enzyme inhibitors, molecular modeling was used to inspect the binding mode of perillaldehyde and D-limonene, the major compounds of essential oil of Algerian Ammodaucus leucotrichus into the active site pocket of cholinesterase (AChE and BuChE) and Monoamine Oxidase (MAO). The molecular docking was carried out using Molecular Operating … …Current Research in Bioinformatics, Vol. 8, Issue 1 · 28 Feb 2020 · 7,317 accessesView PDFCite
EditorialOpen accessIn the abstractEditorial Commentary: Challenge of Non–AIDS-Defining Cancers (NADCs), Focusing on Trans Activation Response Element (TAR) RNA Embedding ExosomesLechuang Chen, Ge JinGlobally, 37.9 million people were living with HIV at the end of 2018 (Organization, 2018). Cancer is a major cause of mortality and morbidity in AIDS patients and chronically HIV-infected people. With the aid of combination Antiretroviral Therapy (ART), people living with HIV (PLWH) have a longer life span. However, because the virus is not completely eradicated, PLWH under antiretroviral … …American Journal of Immunology, Vol. 15, Issue 1 · 28 Nov 2019 · 6,662 accessesView PDFCite