71 results for “human agent”

Set a search alert

Research ArticleOpen accessIn the abstractRapamycin Inhibits Cystogenesis by Cystic Epithelial Cells Derived from Human Autosomal Dominant Polycystic KidneysGerard Elberg, Teresa V. Lewis, Lijuan Chen, Martin A. TurmanAutosomal dominant polycystic kidney disease (ADPKD) is one of the most common genetic disorders and carries a high health burden since it progresses to renal failure in half of the afflicted individuals by the 6th decade of life. Currently, there is no effective treatment to slow the progression of ADPKD. Rapamycin, a drug most commonly used as an immunosuppressive agent … …American Journal of Pharmacology and Toxicology, Vol. 1, Issue 4 · 31 Dec 2006 · 7,101 accessesView PDF Cite

Research ArticleOpen accessIn the abstractApplications of Real-time Reverse Transcription Polymerase Chain Reaction in Clinical Virology Laboratories for the Diagnosis of Human DiseasesR. Manojkumar, V. MrudulaEarly diagnosis that prevents further expansion of the causative agent and thereby aids control and eradication of infectious agents is critical for countries trying to obtain a particular disease free status. In these diagnostics speed is paramount, including the assay’s applicability, sensitivity, specificity, cost effectiveness and patentability. Real-time Reverse Transcription PCR (rRT-PCR) has revolutionized the field of molecular biology and … …American Journal of Infectious Diseases, Vol. 2, Issue 4 · 31 Dec 2006 · 6,553 accessesView PDF Cite

Research ArticleOpen accessIn the abstractInduction of Caspase-dependant Apoptosis by Enterovirus 70 in Human Lens Epithelial SRA01/04 CellsDequan Chen, Chris Duggan, Donald E. Texada et al.Enterovirus 70 (EV70), an etiological agent of acute hemorrhagic conjunctivitis (AHC), induces apoptosis in human Chang’s conjunctival (HCC) cells. EV70 is also able to infect and replicate in some other human cells such as human lens epithelial SRA01/04 cells and U937 cells. EV70 infection was found to induce apoptosis in SRA01/04 cells. During EV70-induced apoptosis of SRA01/04 cells, the expression … …American Journal of Infectious Diseases, Vol. 1, Issue 2 · 30 Jun 2005 · 6,636 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCopper (I)-Nicotinate Promotes Gene Expression of CYPs that Produce M1 and Q1 in Aflatoxicosed RatsMohammed Salah, Laila Mostafa, Tahia H. Saleem et al.Aflatoxin-contaminated food poses a serious risk to both human and animal health. Copper (1)-nicotinate (Cu+-nicotinate) complex potentiated the prophylactic effect against chronic aflatoxicosis in the experimental animals through the synthesis of less toxic metabolites M1 and Q1 which are easily excreted in urine. To investigate the action of the safety Cu+-nicotinate complex on gene expression of Cytochrome 450 (CYP450) system, … …American Journal of Biochemistry and Biotechnology, Vol. 16, Issue 1 · 28 Jan 2020 · 8,152 accessesView PDF Cite

Short CommunicationsOpen accessIn the abstractCytotoxicity and Apoptosis-Induction Potential of Fraction F3 from Fruits of Bersama engleriana (Melanthaceae) against Human Cervical Cancer CellsMichèle Stella Majoumouo et al.Cervical cancer is one of the most life-threatening malignancies worldwide, despite intensive research for more efficacious chemotherapeutic agents. Recent efforts geared towards eradicating the scourge of cancer have embodied a major surge of interest in natural products as promising lead molecules in pharmaceutical development and therapeutic translation. Consequently, this study aimed to assess the cytotoxicity of a previously identified plant … …American Journal of Biochemistry and Biotechnology, Vol. 18, Issue 4 · 5 Dec 2022 · 5,292 accessesView PDF Cite

Review ArticleOpen accessIn the abstractFood Safety and Fish Production the Case of Staphylococcus aureus: A ReviewAlejandro De Jesús Cortés-Sánchez, Mayra Díaz-Ramírez, Ma. De la Paz Salgado-Cruz, Rocío G. Hernandez-NavaCurrently food safety must be a mandatory condition in food available for human and animal consumption. Food safety is considered the characteristic that these will not cause harm to the health of consumers. Foodborne diseases are considered a serious public health problem throughout the world due to their incidence, mortality and negative repercussions on the economic and productive sectors. Among … …OnLine Journal of Biological Sciences, Vol. 20, Issue 4 · 1 Jan 2021 · 7,335 accessesView PDF Cite

Research ArticleOpen accessIn the abstractThe Polarity of Organic Solvents in Coriander Seed Powder (Coriandrum Sativum) Extract is Dependent on their Content of Beta-Carotene, Total Phenolics, Flavonoids, Antioxidants, and Antibacterial PropertiesUcop Haroen, Syafwan, Agus Budiansyah, Kiki KurniawanAttempts to develop alternative antibiotics from herbal plants, especially those originating from spice plants that contain active compounds, are crucial to improve livestock health and support the growth of livestock to reach their genetic potential. This study aims to examine the effects of utilizing different solvent polarities on the solubility of coriander seed secondary metabolite chemicals, which are associated with … …American Journal of Animal and Veterinary Sciences, Vol. 20, Issue 3 · 6 Nov 2025 · 2,332 accessesView PDF Cite

Research ArticleOpen accessIn the abstractEnhancing Telecommunication Network Management with Autonomous Optimization Agents and Machine LearningDanny Adil Sibarani, Evaristus Didik MadyatmadjaThis study explores the integration of Machine Learning (ML) and Autonomous Optimization Agents (AOAs) in the management and optimization of Radio Access Networks (RAN). The research addresses the growing challenges posed by the need for skilled network experts capable of managing and analyzing large-scale network data, including Key Performance Indicators (KPIs) and thousands of network configuration parameters. To overcome these … …Journal of Computer Science, Vol. 21, Issue 2 · 4 Mar 2025 · 7,041 accessesView PDF Cite

Research ArticleOpen accessIn the abstractCYCLIC CHOLECYSTOKININ ANALOGUES EXHIBIT HIGH BLOOD STABILITY AND BINDING AFFINITY WITH CHOLECYSTOKININ RECEPTOREun-Ha Joh, Jae Cheong Lim, Jin Joo Kim et al.Recently, incidence of Cholecystokinin (CCK) receptor is recognized as a factor that determines the aggressive phenotype of pancreatic cancer. In this study, a novel Cholecystokinin (CCK) analogues; DOTA-Nle-cyclo (Glu-Trp-Met-Asp-Phe-Lys-NH2) (DOTA-cCCK) and DOTA-Nle-cyclo (Glu-Trp-Nle-Asp-Phe-Lys-NH2) (DOTA-[Nle]-cCCK) were synthesized and radiolabeled and the targeting abilities on the CCK receptor were evaluated for new CCK receptor targeting agents searching. Peptides were prepared through a … …OnLine Journal of Biological Sciences, Vol. 14, Issue 1 · 2 Jan 2014 · 7,556 accessesView PDF Cite

Research ArticleOpen accessIn the abstractQuantification of Zolpidem in Canine PlasmaMario Giorgi, Alessandra Gavazza, Hyoin YunProblem statement: Zolpidem is a non-benzodiazepine hypnotic agent currently used in human medicine. In contrast to benzodiazepines, zolpidem preferentially binds with the GABAA complex ϖ1 receptors while poorly interacting with the other ϖ receptor complexes. Recent studies have suggested that ZP may be used to initiate sedation and diminish severe anxiety responses in dogs. The aim of the present study … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 19 Mar 2012 · 7,908 accessesView PDF Cite