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53 articles for “drug administration”
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Research ArticleOpen accessIn the abstractTramadol Vs Tapentadol: Anew Horizon in Pain Treatment?Mario GiorgiProblem statement: Acute and chronic pain is a common presenting sign in animal species and human beings. Approach: Classical opioids provide very effective pain relief, although they may be less effective in the treatment of chronic pain due to their limited therapeutic windows and the induced opioid receptor down regulation. Atypical opioids, such as tramadol and tapentadol, have a dual … …American Journal of Animal and Veterinary Sciences, Vol. 7, Issue 1 · 25 Feb 2012 · 17,881 accessesView PDFCite
Research ArticleOpen accessIn the abstractEffect of Saffron on Histomorphometric Changes of Testicular Tissue in RatMirhadi Khayatnouri, Seyed Esmail Safavi, Saied Safarmashaei et al.Problem statement: Saffron is widely used as a food flavor and has well known medicinal effects. This drug has an effect on steroid and sexual hormones. The aim of this study was investigation of Saffron orally administration on histomorphometric change of testicular tissue in rat. In this experimental study, 40 male rats are used (4 groups and 10 rats in … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 4 · 11 Jan 2012 · 7,968 accessesView PDFCite
Research ArticleOpen accessIn the abstractCase Report of Severe Injection Site Reaction Associated with Intramuscular NaltrexoneJill A. Covyeou, Katharine E. Atto, Chadwick W. Howard, Jessica R. SchultzProblem statement: To report a case of severe injection site reaction at the site of an IM naltrexone injection in a 30 year old female. Approach: A 30 year old female, being treated with naltrexone extended-release injectable suspension for alcohol dependence, presented with a mass on her left upper gluteal area at the site of injection. The injectable naltrexone was … …American Journal of Pharmacology and Toxicology, Vol. 6, Issue 1 · 7 Jun 2011 · 7,663 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Ivermectin Pour-on Administration Against Natural Heterakis gallinarum Infestation and its Prevalence in Native PoultryM. H. Khayatnouri, Y. Garedaghi, A. R. Arbati, H. KhaliliProblem statement: One of the real problems that cause the economic prejudice in animal farms yearly is parasitic diseases. To overcome these problems the use of antiparasitic drugs is necessary. Ivermectin is a broad spectrum antiparasitic agent and different routes of its administration such as injection, oral and pour-on were used. The aims of the current study were evaluation of … …American Journal of Animal and Veterinary Sciences, Vol. 6, Issue 1 · 25 May 2011 · 12,059 accessesView PDFCite
Research ArticleOpen accessIn the abstractPersonality Traits as Predictors towards Readiness to Change among Female Drug AddictsW.S. Wan Shahrazad, Z.M. Lukman, A.R. Roseliza Murni et al.Problem statement: Understanding the personality traits among women who are involved in drug addiction is a crucial issue prior to starting any intervention programs. It may provide an indication of their readiness to receive treatment and change this addictive behavior. This study was conducted to examine the predictive relationship between personality traits and readiness to change among women drug addicts … …American Journal of Applied Sciences, Vol. 8, Issue 2 · 28 Feb 2011 · 7,895 accessesView PDFCite
Research ArticleOpen accessIn the abstractMethamphetamine Regulation of Sulfotransferases in Rat Liver and BrainTianyan Zhou, Chaoqun Huang, Yue Chen et al.Problem statement: Sulfotransferases (SULTs) are important phase II drug metabolizing enzymes. They also regulate the biological activities of various hormones. To the best of our knowledge, psychostimulants regulation of SULTs is basically not studied except one article reported that Methamphetamine (METH) treatment induced rat amygdale rSULT1A1 mRNA 4.3 fold by using microarray method to identify a series of candidate genes … …American Journal of Pharmacology and Toxicology, Vol. 5, Issue 3 · 30 Sep 2010 · 7,686 accessesView PDFCite
Research ArticleOpen accessIn the abstractTamoxifen Drug Loading Solid Lipid Nanoparticles Prepared by Hot High Pressure Homogenization TechniquesNagi A. ALHaj, Rasedee Abdullah, Siddig Ibrahim, Ahmad BustamamAs drug delivery systems Nanoparticulate widely investigated because of many advantages such as smaller size, controlled drug release potential, targeting ability, enhancement of therapeutic efficacy and reduction of toxicity. So, Solid Lipid Nanoparticles have recently received considerable attention as alternative drug delivery carrier. In this study Solid Lipid Nanoparticles (SLNs) containing tamoxifen, nonsteroidal antiestrogens have been loaded and to be … …American Journal of Pharmacology and Toxicology, Vol. 3, Issue 3 · 30 Sep 2008 · 15,176 accessesView PDFCite
Research ArticleOpen accessIn the abstractThe Effect of Omega-3 Fatty Acids on Nerve Conduction Velocity (NCV) and F-wave Latency in Patients with Diabetic polyneuropathyNaser Zangiabadi, Mohamad N. Ahrari, Nouzar NakhaeeDiabetes mellitus with the prevalence rate of 8.9-12.3% in human population, ultimately leads to the peripheral nervous system involvement in many patients. It causes various types of polyneuropathies, which may manifest abnormalities such as impaired nerve conduction velocity (NCV) and prolonged F-wave latency. The aim of this study was to investigate the effect of omega-3 fatty acids on NCV and … …American Journal of Pharmacology and Toxicology, Vol. 2, Issue 1 · 31 Mar 2007 · 9,279 accessesView PDFCite
Research ArticleOpen accessIn the abstractRole of HIV-1 Infection in Addictive Behavior: A Study of a HIV-1 Transgenic Rat ModelSulie L. Chang, Michael VigoritoEpidemiological research indicates that drug abuse is prevalent among individuals infected with HIV-1. Evidence from preclinical research also suggests that drugs of abuse exacerbate the progression of neuropathological changes in the HIV-1 infected brain probably through common mechanisms of neuronal injury. The effects of HIV-1 on the efficacy and abuse potential of controlled drugs such as morphine, however, has not … …American Journal of Infectious Diseases, Vol. 2, Issue 2 · 30 Jun 2006 · 7,634 accessesView PDFCite
Research ArticleOpen accessIn the abstractLoss of Morphine-induced Suppression of NK Cell activity and T-cell Functions in µ-Opioid Receptor Knockout MiceRichard J. Weber, Ricardo Gomez-Flores, Ichiro Sora, George R. UhlIn vivo administration of µ-opioid receptor selective agonists to various species is known to suppress lymphocyte, NK cell, and macrophage functions, in addition to mediate pain relief and euphoria. Using a mouse model in which the µ-opioid receptor gene was disrupted by targeted homologous recombination, we explored the involvement of this receptor in natural killer (NK) cell activity and T … …American Journal of Immunology, Vol. 2, Issue 2 · 30 Jun 2006 · 6,941 accessesView PDFCite